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公开(公告)号：US06500438B2
公开(公告)日：2002-12-31
申请号：US08973133
申请日：1997-12-01
IPC分类号： A61K39012
CPC分类号： A61K39/012 , A61K2039/51 , A61K2039/522 , A61K2039/55
摘要： The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.
摘要翻译： 本发明涉及一种针对球虫病接种家禽的方法，其中包括以卵内施用有效免疫剂量的活艾美球虫子孢子或裂殖子或其混合物。 在优选的实施方案中，被接种的驯养的鸟是鸡或火鸡。
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公开(公告)号：US06495146B1
公开(公告)日：2002-12-17
申请号：US08973151
申请日：1997-12-01
IPC分类号： A61K3900
CPC分类号： A61K39/012
摘要： The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.
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公开(公告)号：US07018640B2
公开(公告)日：2006-03-28
申请号：US10094436
申请日：2002-03-08
IPC分类号： A61K39/00 , A61K39/38 , A61K39/012 , A61K39/002 , A61K39/008
CPC分类号： A61K39/012 , A61K2039/51 , A61K2039/522 , A61K2039/55
摘要： The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immnunizing dose of live Eimeria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.
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公开(公告)号：US06627205B2
公开(公告)日：2003-09-30
申请号：US10094087
申请日：2002-03-08
IPC分类号： A61K39012
CPC分类号： A61K39/012 , A61K2039/52 , A61K2039/54
摘要： The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.
摘要翻译： 本发明涉及一种针对球虫病接种驯养的禽类的方法，其包括在卵内施用有效免疫剂量的活艾美球虫孢子囊或卵囊或其混合物。
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5.发明授权Myostatin regulatory region, nucleotide sequence determination and methods for its use 失效肌生成抑制素调节区，核苷酸序列测定及其使用方法公开(公告)号：US06617440B1
公开(公告)日：2003-09-09
申请号：US09626959
申请日：2000-07-27
申请人： Robert Craig Findly
发明人： Robert Craig Findly
IPC分类号： C07H2104
CPC分类号： C07K14/475 , A01K2217/05 , A61K48/00
摘要： The present invention relates to a transcription regulatory region of a myostatin gene. In particular, the invention relates to a 2.5 kb polynucleotide immediately 5′ to the myostatin coding sequence, its nucleotide sequence and methods of using this regulatory region, and fragments thereof. The present invention relates to the use of the myostatin promoter of the present invention to direct expression of a target gene in a tissue specific manner, i.e. muscle tissue. The present invention relates to the use of the myostatin promoter of the present invention in high throughput screens to identify test compounds which inhibit myostatin promoter activity or myostatin expression. In accordance with the present invention, inhibitors of the myostatin promoter may be used to inhibit myostatin expression as a method of engineering animals with increased lean meat in order to decrease the time required to bring the animals to slaughter, and of promoting muscle growth for treating disorders related to expression of the myostatin gene, such as muscle wasting associated with aging or disease in humans and companion animals, particularly cats and dogs.
摘要翻译： 本发明涉及肌生成抑制素基因的转录调节区。 特别地，本发明涉及一种2.5kb的多核苷酸，其立即与肌生成抑制素编码序列5'，其核苷酸序列和使用该调节区的方法及其片段相关。 本发明涉及本发明的肌生成抑制素启动子以组织特异性方式（即肌肉组织）直接表达靶基因的用途。 本发明涉及本发明的肌生成抑制素启动子在高通量筛选中用于鉴定抑制肌生成抑制素启动子活性或肌生成抑制素表达的测试化合物。 根据本发明，肌生成抑制素启动子的抑制剂可用于抑制肌生成抑制素表达，作为工程化瘦肉增加的动物的方法，以减少使动物屠宰所需的时间，并促进肌肉生长用于治疗 与肌生成抑制素基因表达相关的疾病，例如与人类和伴侣动物，特别是猫和狗中的衰老或疾病相关的肌肉萎缩。
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