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    PDE1 inhibitors for ophthalmic disorders
    1.
    发明授权
    PDE1 inhibitors for ophthalmic disorders 有权

    公开(公告)号：US11464781B2

    公开(公告)日：2022-10-11

    申请号：US13203365

    申请日：2010-02-24

    申请人： Robert Davis ,  Allen Fienberg

    发明人： Robert Davis ,  Allen Fienberg

    IPC分类号： A61K31/535 ,  A61K9/00 ,  A61K31/5575 ,  A61P27/06

    摘要： Compounds that inhibit phosphodiesterase 1 (PDE1) are useful to treat glaucoma or elevated intraocular pressure. The PDE1 inhibitors may be administered as monotherapy or in combination with additional intraocular-pressure lowering agents. In addition, the invention provides ophthalmic compositions comprising PDE 1 inhibitors and optionally one or more additional intraocular pressure-lowering agents. Topical and systemic therapy may be used.

    No/low skid device
    2.
    发明授权
    No/low skid device 有权

    公开(公告)号：US11260967B1

    公开(公告)日：2022-03-01

    申请号：US16122144

    申请日：2018-12-03

    申请人： James Robert Davis

    发明人： James Robert Davis

    IPC分类号： B64C25/40 ,  B64C25/36 ,  B60B7/00

    摘要： An aircraft hubcap/wheel cover which uses ambient airflow (120 mph-175 mph) to rotate wheels on the landing gear of an aircraft accomplished by using slightly protruding slats, blades, scoops or other air capturing shapes, (once the landing gear has been lowered). These air capturing shapes are integrated as part of the hubcap/wheel cover during manufacture and are directly determined by ground speed applicable to that aircraft with the ultimate purpose being tire longevity. The wheel cover hubcap is a single piece design and has no moving parts.

    Radiant heating umbrella
    5.
    发明授权
    Radiant heating umbrella 有权
    辐射加热伞

    公开(公告)号：US09149097B1

    公开(公告)日：2015-10-06

    申请号：US14656330

    申请日：2015-03-12

    申请人： Marvin Robert Davis

    发明人： Marvin Robert Davis

    IPC分类号： A45B23/00 ,  F24C1/12

    CPC分类号： A45B23/00 ,  A45B2023/0012 ,  A45B2025/186 ,  A45B2200/1009 ,  F24C1/12

    摘要： An apparatus having a radiant heater, an upwardly convex reflector, a vertically-oriented cylindrical ring shield joined to the reflector at the outside reflector diameter, an upwardly convex metal hood, and an upwardly convex cap having a cap diameter greater than the diameter of a hood opening, wherein exhaust gases emitted upwardly from the exhaust port draw cooler air through the cylindrical opening, the exhaust gases and cooler air pass upward through the hood, drawing additional cooler air through the annular space between the reflector and the hood, into a mixing chamber formed by the cap and the hood, where the cooler air and the exhaust gases mix and the mixed air and exhaust gases then pass outward through the annular space between the cap and the hood, exiting the apparatus at the outer diameter of the cap.

    摘要翻译： 具有辐射加热器，向上凸起的反射器，在外部反射器直径处接合到反射器的垂直取向的圆柱形屏蔽罩的装置，向上凸起的金属罩和具有大于直径的帽直径的向上凸出的盖 机罩开口，其中从排气口向上排出的废气通过圆柱形开口抽吸冷却器空气，排气和较冷空气向上穿过罩，将另外的较冷空气通过反射器和罩之间的环形空间抽入混合 由盖和罩形成的室，其中较冷的空气和排气混合，混合的空气和废气然后通过盖和罩之间的环形空间向外通过，在盖的外径处离开设备。

    TRANSDERMAL APPLICATION OF PROSTAGLANDIN E1 FOR THE TREATMENT OF OCULAR ISCHEMIA
    6.
    发明申请
    TRANSDERMAL APPLICATION OF PROSTAGLANDIN E1 FOR THE TREATMENT OF OCULAR ISCHEMIA 审中-公开
    PROSTAGLANDIN E1的转移应用用于治疗眼肌炎

    公开(公告)号：US20140377337A1

    公开(公告)日：2014-12-25

    申请号：US14376366

    申请日：2013-02-04

    申请人： Robert Davis STEIGERWALT, JR.

    发明人： Robert Davis Steigerwalt, JR.

    IPC分类号： A61K31/19 ,  A61K9/00

    CPC分类号： A61K31/19 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/1075 ,  A61K9/12 ,  A61K31/5575 ,  A61K47/24 ,  A61K47/40

    摘要： The invention concerns the use of a preparation based on prostaglandin E1 (PGE1) as active ingredient in a carrier suitable for administration on the skin or on the mucous membranes, for the treatment by the transdermal or transmucosal route of acute or chronic ophthalmic pathologies of an ischemic nature, and in general for the treatment of ophthalmic pathologies involving at least in part an ischemic mechanism of the ocular district.By applying PGE1 on the skin, particularly in the form of a cream, it is possible to avoid the drawbacks of the intravenous administration of the drug, while still maintaining a comparable level of absorption of the drug in the ocular district. By suitably modulating the dosage, it is possible to obtain in the eye, by the cutaneous administration of PGE1, the same clinical results that can be obtained by intravenous administration.

    摘要翻译： 本发明涉及基于前列腺素E1（PGE1）作为活性成分的制剂在适用于皮肤或粘膜上施用的载体中的用途，用于通过经皮或经粘膜途径治疗急性或慢性眼科病症 缺血性质，一般用于治疗至少部分涉及眼部区域缺血机制的眼科病症。 通过将PGE1施用于皮肤，特别是以霜剂的形式，可以避免药物的静脉内给药的缺点，同时仍然保持药物在眼部区域中相当的吸收水平。 通过适当调节剂量，可以通过皮肤给药PGE1获得与静脉内给药相同的临床结果。

    CUSTOM MESSAGE PRESENTATION
    7.
    发明申请
    CUSTOM MESSAGE PRESENTATION 有权
    自定义消息呈现

    公开(公告)号：US20130246539A1

    公开(公告)日：2013-09-19

    申请号：US13420246

    申请日：2012-03-14

    申请人： Robert Davis

    发明人： Robert Davis

    IPC分类号： G06F15/16

    CPC分类号： G06Q30/0271 ,  G06Q30/0241 ,  G06Q30/0267

    摘要： For custom message presentation, an identification module identifies an optical code as not communication ready. A message module generates a custom message indexed to the optical code in response to identifying the optical code as not communication ready. The message module further makes the optical code communication ready in response to generating the custom message. In addition, the message module communicates the custom message in response to receiving the optical code and identifying the optical code as communication ready.

    摘要翻译： 对于自定义消息呈现，识别模块将光学代码识别为不通信就绪。 响应于将光学代码识别为不通信就绪，消息模块生成索引到光学代码的自定义消息。 响应于生成定制消息，消息模块进一步使得光学代码通信准备就绪。 此外，消息模块响应于接收到光学代码并将光学代码识别为通信就绪而传送定制消息。