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1.
公开(公告)号:US20080038248A1
公开(公告)日:2008-02-14
申请号:US10589851
申请日:2005-02-17
申请人: John Trowsdale , Robert Eagle , Louise Bacon
发明人: John Trowsdale , Robert Eagle , Louise Bacon
IPC分类号: A61K39/395 , A61K31/711 , A61P35/00 , C07H21/04 , C07K16/00 , C12N15/63 , G01N33/53 , G01N33/50 , C12N1/21 , C07K14/00 , A61P37/00 , A61K38/16
CPC分类号: C07K14/705
摘要: A novel member of the RAET1/ULBP family of proteins (RAET1G) is identified and characterised and shown to bind the UL16 and NKG2D receptors with high affinity. RAET1G exhibits restricted expression in normal tissues but exhibits high levels of expression in tumours and may be differentially spliced in cancer cells to produce a soluble protein. RAET1G is also up-regulated in inflammatory diseases such as coeliac disease. RAET1G may be used as a novel marker for disease conditions including cancer conditions and inflammatory diseases.
摘要翻译: RAET1 / ULBP蛋白家族(RAET1G)的新成员被鉴定和表征,并显示以高亲和力结合UL16和NKG2D受体。 RAET1G在正常组织中表现出限制性表达,但在肿瘤中表现出高水平的表达,并且可能在癌细胞中差异性剪接以产生可溶性蛋白质。 RAET1G也在炎症性疾病如乳糜泻中上调。 RAET1G可用作疾病状况的新型标志物,包括癌症和炎性疾病。
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公开(公告)号:US06196547B1
公开(公告)日:2001-03-06
申请号:US09247441
申请日:1999-02-10
申请人: Andrew Pascal , John Kelly , Sharon Glusker , Mark Nicely , Robert (Eagle) Burns
发明人: Andrew Pascal , John Kelly , Sharon Glusker , Mark Nicely , Robert (Eagle) Burns
IPC分类号: A63F100
CPC分类号: A63F3/00157 , A63F1/18
摘要: A process of dealing and drawing cards is provided wherein a player hand including N cards is dealt to the player from a computer card deck. An opponent hand including N cards is dealt to the opponent from the deck. The player and the opponent are provided with opportunity to draw cards. A gaming system determines which cards of the initial opponent hand to hold and which to discard using a play strategy-lookup table in accordance with the present invention. The strategy look-up table is addressed using an address set including all possible hands that could be dealt in an N card poker game. Each address of the address set stores a corresponding optimal hold scenario which provides information indicating which of the particular N cards of a hand to hold and which to discard in order have the greatest probability of winning. Cards are discarded from the initial opponent hand according to the look up table. A replacement card is dealt to the computer opponent from the deck for each card discarded from the opponent hand. The final opponent hand, including the final card values are then revealed and a winning hand is determined.
摘要翻译: 提供交易和绘图卡的过程,其中包括N张牌的玩家手从计算机卡片卡片发给玩家。 包含N张牌的对手手牌从甲板处理给对手。 玩家和对手都有机会吸卡。 根据本发明,游戏系统使用播放策略查找表来确定初始对手的哪个卡被保持以及哪个卡丢弃。 策略查找表使用包含可在N卡扑克游戏中处理的所有可能的手的地址集来解决。 地址集的每个地址存储相应的最佳保留场景,该场景提供指示要保持的特定N个卡的哪个以及依次丢弃具有最大获胜概率的信息。 根据查看表,牌从初始的对手手中丢弃。 从对手手中丢弃的每张卡片,甲板上的电脑对手处理一张替换卡。 最后的对手,包括最终的卡牌,然后被揭示,并确定一个胜利的手。
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公开(公告)号:USD247027S
公开(公告)日:1978-01-24
申请号:US693989
申请日:1976-06-08
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