公开(公告)号：US06982168B1

公开(公告)日：2006-01-03

申请号：US08913770

申请日：1997-01-30

Applicant: Suzanne L. Topalian ,  W. Marston Linehan ,  Robert K. Bright ,  Cathy D. Vocke

Inventor： Suzanne L. Topalian ,  W. Marston Linehan ,  Robert K. Bright ,  Cathy D. Vocke

IPC: C12N15/85

CPC classification number: A61K38/00 ,  A61K39/00 ,  C07K16/18 ,  C12N5/0683 ,  C12N5/0693 ,  C12N15/85

Abstract: The present invention relates to immortalized, malignant, human, adult prostate epithelial cell lines or cell lines derived therefrom useful in the diagnosis and treatment of prostate cancer. More particularly, the present invention relates to cloned, immortalized, malignant, human, adult prostate epithelial cell lines and uses of these cell lines for the diagnosis and treatment of cancer. Furthermore, the present invention provides for the characterization of said cell lines through the analysis of specific chromosomal deletions.

Abstract translation: 本发明涉及可用于诊断和治疗前列腺癌的永生化，恶性，人类，成年前列腺上皮细胞系或其衍生的细胞系。 更具体地，本发明涉及克隆的，永生化的，恶性的，人类，成年前列腺上皮细胞系和这些细胞系用于诊断和治疗癌症的用途。 此外，本发明通过分析特异性染色体缺失来提供所述细胞系的表征。