公开(公告)号：US20130091611A1

公开(公告)日：2013-04-18

申请号：US13691099

申请日：2012-11-30

申请人： Guogang Ren ,  John S. Oxford, Prof. ,  Paul William Reip ,  Robert Lambkin-Williams ,  Alexander Mann

发明人： Guogang Ren ,  John S. Oxford, Prof. ,  Paul William Reip ,  Robert Lambkin-Williams ,  Alexander Mann

IPC分类号： A41D13/11 ,  A01N25/34

CPC分类号： A41D13/1192 ,  A01N25/34 ,  A62B23/00 ,  B82Y5/00 ,  Y10T442/603 ,  A01N59/00 ,  A01N59/02 ,  A01N59/06 ,  A01N59/16 ,  A01N59/20 ,  A01N59/26

摘要： The present invention provides the use of nanoparticles of a compound of general formula MnXy, where M is (i) a metal selected from the group consisting of Calcium (Ca), Aluminium (Al), Zinc (Zn), Nickel (Ni), Tungsten (W) or Copper (Cu); or (ii) a non-metal selected from the group consisting of Silicon (Si), Boron (B) or Carbon (C); in which n is equal to 1, 2, or 3, and X is (iii) a non-metal selected from the group consisting of Oxygen (O), Nitrogen (N), or Carbon (C); or (iv) an anion selected from the group consisting of phosphate (PO43−), hydrogen phosphate (HPO42−), dihydrogen phosphate (H2PO4−), carbonate (CO3), silicate (SiO42−), sulphate (SO42−), nitrate (NO3−), nitrite (NO2−); in which y is equal to 0, 1, 2, 3 or 4; for use in reducing and/or preventing virus transmission. Articles of protective clothing or filters are provided in which the fibres are coated with said nanoparticles for use in reducing and/or preventing virus transmission.

摘要翻译： 本发明提供了通式MnXy化合物的纳米颗粒的用途，其中M是（i）选自钙（Ca），铝（Al），锌（Zn），镍（Ni）， 钨（W）或铜（Cu）; 或（ii）选自硅（Si），硼（B）或碳（C）的非金属; 其中n等于1,2或3，X是（iii）选自氧（O），氮（N）或碳（C）的非金属; 或（iv）选自磷酸盐（PO43-），磷酸氢盐（HPO42-），磷酸二氢盐（H2PO4-），碳酸盐（CO3），硅酸盐（SiO42-），硫酸盐（SO42-），硝酸盐 （NO3-），亚硝酸盐（NO2-）; 其中y等于0,1,2,3或4; 用于减少和/或防止病毒传播。 提供防护衣物或过滤器的制品，其中纤维被所述纳米颗粒包被以用于减少和/或防止病毒传播。

公开(公告)号：US20130164315A1

公开(公告)日：2013-06-27

申请号：US13336648

申请日：2011-12-23

申请人： Robert Lambkin-Williams ,  John S. Oxford ,  Thomas Wilkinson

发明人： Robert Lambkin-Williams ,  John S. Oxford ,  Thomas Wilkinson

IPC分类号： A61K39/12 ,  C40B30/06 ,  C07K7/06 ,  A61P31/12 ,  C07K14/11 ,  A61K39/145 ,  A61P31/16 ,  C12Q1/02 ,  C07K7/08

CPC分类号： G01N33/505 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134

摘要： The present invention provides a screening method for identifying a peptide capable of inducing a T cell response comprising: a) contacting a peptide having a level of identity with a sequence of a protein of a virus, with a test sample comprising T cells obtained from blood from a subject who is currently or has been recently infected with the virus, b) quantifying the response of the T cells to the peptide, c) comparing the T cells' response in b) to a response of a control sample comprising T cells obtained from blood from a subject who is not currently infected nor been recently infected with the virus, when contacted with the peptide, wherein a greater response to the peptide in b) than in c) is indicative of a peptide capable of inducing a T cell response.

摘要翻译： 本发明提供了一种用于鉴定能够诱导T细胞应答的肽的筛选方法，包括：a）将与病毒蛋白质序列具有一致性的肽与包含从血液获得的T细胞的测试样品 来自目前或已经最近感染病毒的受试者，b）量化T细胞对肽的反应，c）比较b）中T细胞的反应与包含获得的T细胞的对照样品的应答 来自未被感染的受试者的血液或最近感染了病毒，当与肽接触时，其中b）中对肽的更大反应比c）指示能够诱导T细胞应答的肽 。

公开(公告)号：US20100040655A1

公开(公告)日：2010-02-18

申请号：US12279627

申请日：2007-02-16

申请人： Guogang Ren ,  John Sidney Oxford ,  Paul William Reip ,  Robert Lambkin-Williams ,  Alexander Mann

发明人： Guogang Ren ,  John Sidney Oxford ,  Paul William Reip ,  Robert Lambkin-Williams ,  Alexander Mann

IPC分类号： A01N59/26 ,  A01N59/16 ,  A01N59/06 ,  A01N25/34 ,  A01N25/08 ,  A01P1/00

CPC分类号： A41D13/1192 ,  A01N25/34 ,  A62B23/00 ,  B82Y5/00 ,  Y10T442/603 ,  A01N59/00 ,  A01N59/02 ,  A01N59/06 ,  A01N59/16 ,  A01N59/20 ,  A01N59/26

摘要： The present invention provides the use of nanoparticles of a compound of general formula MnXy, where M is (i) a metal selected from the group consisting of Calcium (Ca), Aluminium (Al), Zinc (Zn), Nickel (Ni), Tungsten (W) or Copper (Cu); or (ii) a non-metal selected from the group consisting of Silicon (Si), Boron (B) or Carbon (C); in which n is equal to 1, 2, or 3, and X is (iii) a non-metal selected from the group consisting of Oxygen (O), Nitrogen (N), or Carbon (C); or (iv) an anion selected from the group consisting of phosphate (PO43−), hydrogen phosphate (HPO42−), dihydrogen phosphate (H2PO4−), carbonate (CO3), silicate (SiO42−), sulphate (SO42−), nitrate (NO3−), nitrite (NO2−); in which y is equal to 0, 1, 2, 3 or 4; for use in reducing and/or preventing virus transmission. Articles of protective clothing or filters are provided in which the fibres are coated with said nanoparticles for use in reducing and/or preventing virus transmission.

摘要翻译： 本发明提供了通式MnXy化合物的纳米颗粒的用途，其中M是（i）选自钙（Ca），铝（Al），锌（Zn），镍（Ni）， 钨（W）或铜（Cu）; 或（ii）选自硅（Si），硼（B）或碳（C）的非金属; 其中n等于1,2或3，X是（iii）选自氧（O），氮（N）或碳（C）的非金属; 或（iv）选自磷酸盐（PO43-），磷酸氢盐（HPO42-），磷酸二氢盐（H2PO4-），碳酸盐（CO3），硅酸盐（SiO42-），硫酸盐（SO42-），硝酸盐 （NO3-），亚硝酸盐（NO2-）; 其中y等于0,1,2,3或4; 用于减少和/或防止病毒传播。 提供防护衣物或过滤器的制品，其中纤维被所述纳米颗粒包被以用于减少和/或防止病毒传播。