公开(公告)号：US20240358826A1

公开(公告)日：2024-10-31

申请号：US18574857

申请日：2022-07-08

申请人： Orionis Biosciences, Inc. ,  Orionis Biosciences BV

发明人： Nikolai KLEY ,  Erik DEPLA ,  Joris WAUMAN ,  Enkeleda NAKUCI ,  Yen-Ching HO ,  Alexander Lee KLEY

IPC分类号： A61K39/39 ,  A61K38/00 ,  A61K39/00 ,  A61K39/145 ,  A61K39/215 ,  A61K39/395 ,  C07K14/545 ,  C07K16/30

CPC分类号： A61K39/39 ,  A61K39/145 ,  A61K39/215 ,  A61K39/39558 ,  A61K39/4635 ,  C07K14/545 ,  C07K16/30 ,  A61K38/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/544 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55577 ,  C07K2317/569 ,  C07K2319/30

摘要： The present invention relates, in part, to chimeric proteins, chimeric protein complexes, vaccine compositions, and adjuvants that include IL-1α or pro-IL-1α and their use as therapeutic agents or vaccines. The present invention further relates to methods of treatment of various diseases, such as infectious diseases and cancer and methods of vaccination.

公开(公告)号：US20240335525A1

公开(公告)日：2024-10-10

申请号：US18682372

申请日：2022-08-10

申请人： SANOFI PASTEUR INC.

发明人： Mario BARRO ,  Yvonne CHAN ,  Guadalupe CORTES-GARCIA ,  Raul GOMILA ,  Liqun HAN ,  Justin KLEKOTA ,  Fuqin MA ,  Satyajit RAY ,  Svetlana STEGALKINA ,  Tod STRUGNELL ,  Irina USTYUGOVA ,  Thorsten VOGEL ,  Jianxin ZHANG

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C07K14/705 ,  C12N9/24

CPC分类号： A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C07K14/70596 ,  C12N9/2402 ,  C12Y302/01018 ,  A61K2039/645 ,  C07K2319/02 ,  C12N2760/16134

摘要： Provided are modified influenza virus subtype 2 neuraminidase molecules lacking all or substantially all of the stalk region that form active, soluble tetrameric neuraminidase when expressed in host cells and vaccine compositions comprising the tetrameric neuraminidase or a nucleic acid encoding the modified monomeric influenza virus subtype 2 neuraminidase molecules that forms tetrameric NA when expressed in a cell. Also provided are methods of using the vaccine compositions to vaccinate or immunize a subject against influenza virus.

公开(公告)号：US20240335523A1

公开(公告)日：2024-10-10

申请号：US18294912

申请日：2022-08-04

申请人： The Regents of the University of California

发明人： Rebecca Dubois ,  John Dzimianski

IPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/91 ,  C12N2760/16122 ,  C12N2760/16134

摘要： Provided are polypeptides comprising, consisting essentially of, or consisting of a foldon domain comprising an N-linked glycosylation motif. In some embodiments, the foldon domain is fused to a heterologous amino acid sequence, non-limiting examples of which include immunogenic polypeptides. Trimers of three polypeptides of the present disclosure are also provided, as are related immunogenic compositions and methods of inducing an immune response in an individual. Also included are vectors, e.g., cloning and/or expression vectors that include a nucleic acid sequence encoding a foldon as disclosed herein.

公开(公告)号：US20240316179A1

公开(公告)日：2024-09-26

申请号：US18662436

申请日：2024-05-13

申请人： ACADEMIA SINICA

发明人： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

摘要： The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US20240316169A1

公开(公告)日：2024-09-26

申请号：US18576623

申请日：2022-07-01

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Andrew J. Murphy ,  Christos KYRATSOUS ,  Alina BAUM ,  Christopher PETRO

IPC分类号： A61K39/00 ,  A61K39/145 ,  A61K39/215 ,  A61K39/42 ,  A61P37/04

CPC分类号： A61K39/0008 ,  A61K39/145 ,  A61K39/215 ,  A61K39/42 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/545 ,  C12N2770/20023 ,  C12N2770/20052

摘要： Described herein are methods and compositions for directing an antibody response in a subject away from one or more first epitopes of an antigen (e.g., immunodominant epitopes of a vaccine antigen) and towards one or more second epitopes of the antigen by administering one or more antibodies targeting the one or more first epitopes of the antigen.

公开(公告)号：US12098382B2

公开(公告)日：2024-09-24

申请号：US17333904

申请日：2021-05-28

申请人： University of Maryland, College Park

发明人： Daniel R. Perez ,  Hongjun Chen ,  Yibin Cai ,  Lindomar Jose Pena ,  Matthew Angel

IPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/145 ,  C12N7/00 ,  A61K2039/525 ,  A61K2039/543 ,  A61K2039/70 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16151 ,  C12N2760/16162

摘要： Disclosed are compositions and methods comprising one or more recombinant influenza viruses. Recombinant influenza viruses with mutated polymerases and/or rearranged genomes are disclosed. Constructs comprising different influenza nucleic acid sequences are also provided. Methods of inducing protecting immunity with the recombinant influenza viruses are disclosed. Also disclosed are methods of plasmid-free production of influenza virus comprising amplicons comprising one or more of influenza genes.

公开(公告)号：US12098166B2

公开(公告)日：2024-09-24

申请号：US17291924

申请日：2019-11-05

申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH

发明人： Egbert Siegfried Mundt ,  Xiaoping Cui ,  Zenglei Hu

IPC分类号： C07K14/005 ,  A61K9/00 ,  A61K39/00 ,  A61K39/145 ,  A61K39/39 ,  A61P31/16 ,  C12N7/00 ,  C12N15/86 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K9/0019 ,  A61K39/145 ,  A61K39/39 ,  A61P31/16 ,  C12N7/00 ,  C12N15/86 ,  G01N33/56983 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2710/14043 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16152 ,  C12N2760/16163 ,  C12N2760/16171 ,  G01N2333/11 ,  G01N2469/10

摘要： The invention relates to the field of veterinary medicine. The invention provides an immunogenic composition, comprising a hemagglutinin protein of avian influenza virus H5 subtype. Also provided is a method of differentiating animals naturally infected with AIV from animals vaccinated with the immunogenic composition of the invention. The immunogenic composition of the invention can provide a broader, more effective, long-lasting and early onset protection on poultry.

公开(公告)号：US12076391B2

公开(公告)日：2024-09-03

申请号：US18177413

申请日：2023-03-02

申请人： YISHENG BIOPHARMA (SINGAPORE) PTE. LTD.

发明人： Yi Zhang ,  Yuhe Yan ,  Xu Zhang ,  Thomas Anthony Coton

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/145 ,  C12N7/00 ,  C12N2760/16152

摘要： A method for adapting an influenza virus to Vero cells is provided. The method comprises infecting Vero cells with the influenza virus, cultivating the infected Vero cells, harvesting influenza viruses of each passage, wherein infectious dose of the influenza viruses of one passage is greater than or equal to infectious dose of the influenza viruses of a previous passage. The present disclosure also relates to a composition. Said composition comprises polyriboinosinic acid-polyribocytidylic acid, at least one antibiotic or polyamide compound, at least one positive ion, influenza viruses and/or influenza antigens, wherein said influenza viruses and/or influenza antigens are acquired from Vero cell adapted influenza viruses.

公开(公告)号：US12076390B2

公开(公告)日：2024-09-03

申请号：US17405748

申请日：2021-08-18

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Wayne A. Marasco

IPC分类号： A61K39/145 ,  A61P31/16 ,  C07K16/10 ,  A61K39/00

CPC分类号： A61K39/145 ,  A61P31/16 ,  C07K16/1018 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.

公开(公告)号：US20240285750A1

公开(公告)日：2024-08-29

申请号：US18653458

申请日：2024-05-02

申请人： SANOFI

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Saranya SRIDHAR ,  Thorsten VOGEL ,  William WARREN

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61P31/16 ,  A61K2039/53 ,  A61K2039/70

摘要： Disclosed herein are hybrid multivalent vaccine or immunogenic compositions comprising (i) one or more influenza virus proteins selected from one or more influenza virus hemagglutinin (HA) proteins, one or more influenza virus neuraminidase (NA) proteins, or a combination thereof; and (ii) one or more ribonucleic acid molecules encoding one or more influenza virus proteins selected from one or more influenza virus HA proteins, one or more influenza virus NA proteins, or a combination thereof. Also disclosed are methods of using the vaccine or immunogenic compositions.