Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
    2.
    发明授权
    Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography 失效
    通过固定化金属亲和层析法去除蛋白质溶液中的细菌内毒素

    公开(公告)号:US07842187B2

    公开(公告)日:2010-11-30

    申请号:US11088146

    申请日:2005-03-23

    IPC分类号: B01D15/08

    摘要: The present invention relates to the purification of polypeptides and the removal of endotoxin via immobilized metal affinity chromatography (IMAC). More specifically, the invention relates to methods for removing bacterial endotoxin in a protein solution. In specific embodiments, the invention relates to the elimination of endotoxin from Moraxella catarrhalis outer membrane proteins.

    摘要翻译: 本发明涉及多肽的纯化和通过固定化金属亲和层析(IMAC)去除内毒素。 更具体地,本发明涉及在蛋白质溶液中去除细菌内毒素的方法。 在具体实施方案中,本发明涉及消除来自卡他莫拉菌外膜蛋白的内毒素。