公开(公告)号：US20070207163A1

公开(公告)日：2007-09-06

申请号：US11327695

申请日：2006-01-06

申请人： Peter Sondermann ,  Robert Ruber ,  Uwe Jacob

发明人： Peter Sondermann ,  Robert Ruber ,  Uwe Jacob

IPC分类号： A61K39/00 ,  A61K48/00 ,  C07H21/04 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K2299/00

摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modelling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that can be used to separate and/or enrich antibodies.

摘要翻译： 根据本发明的重组可溶性Fc受体的特征在于不存在跨膜结构域，信号肽和糖基化。 通过在原核宿主细胞中表达相应的核酸并获得的包涵体的复性，可容易地获得这样的Fc受体，该程序导致非常均匀和纯的产物。 该产品可用于诊断以及药物应用，也可用于生成晶体结构数据。 这种晶体结构数据可用于人造分子的建模。 另一个实施方案包括将根据本发明的Fc受体偶联到可用于分离和/或富集抗体的固体材料如色谱材料。