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1.发明申请COMBINATIONS OF FESOTERODINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开用于治疗过敏性叶片的菲司托品和唾液酸凝胶的组合公开(公告)号：US20120289566A1
公开(公告)日：2012-11-15
申请号：US13476874
申请日：2012-05-21
IPC分类号： A61K31/4178 , A61P13/00
CPC分类号： A61K31/222 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了包含治疗有效量的延长释放非索罗定或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。 本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放非索罗定或其药学上可接受的盐和治疗有效量 毛果芸香碱或其药学上可接受的盐。 本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放的非索罗定或其药学上可接受的盐 以及治疗有效量的毛果芸香碱或其药学上可接受的盐。
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2.发明申请COMBINATIONS OF SOLIFENACIN AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 有权用于治疗过敏性叶片的溶胶素和唾液酸凝胶的组合公开(公告)号：US20120289544A1
公开(公告)日：2012-11-15
申请号：US13476883
申请日：2012-05-21
IPC分类号： A61K31/439 , A61P13/00
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了包含治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。 本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量 毛果芸香碱或其药学上可接受的盐。 本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐 以及治疗有效量的毛果芸香碱或其药学上可接受的盐。
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公开(公告)号：US20110244051A1
公开(公告)日：2011-10-06
申请号：US13078881
申请日：2011-04-01
申请人： Mehdi PABORJI , Roger S. FLUGEL
发明人： Mehdi PABORJI , Roger S. FLUGEL
IPC分类号： A61K9/16 , A61K31/4178 , A61K31/439 , A61K31/137 , A61K31/222 , A61K31/216 , A61K31/4725 , A61K31/4025 , A61K31/403 , A61K31/4174 , A61K31/445 , A61K31/215 , A61P13/10
CPC分类号： A61K9/1652 , A61K9/1617 , A61K9/1676 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/222 , A61K31/4178
摘要： Disclosed herein are pharmaceutical compositions comprising a plurality of first beads each comprising: a core; a first layer comprising pilocarpine or a pharmaceutically acceptable salt thereof; and a second layer comprising a first polymer. Also disclosed are pharmaceutical compositions comprising a plurality of second beads each comprising: a core; and a first layer comprising tolterodine or a pharmaceutically acceptable salt thereof. Further disclosed are pharmaceutical formulations comprising: a) a plurality of the first beads; b) a plurality of the second beads; or c) a plurality of the first beads and a plurality of the second beads.
摘要翻译： 本文公开了包含多个第一珠粒的药物组合物，每个第一珠粒各自包含：核心; 包含毛果芸香碱或其药学上可接受的盐的第一层; 和包含第一聚合物的第二层。 还公开了包含多个第二珠粒的药物组合物，每个第二珠粒各自包含：核心; 以及包含托特罗定或其药学上可接受的盐的第一层。 进一步公开的是药物制剂，其包含：a）多个第一珠粒; b）多个第二珠粒; 或c）多个第一珠和多个第二珠。
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4.发明申请公开(公告)号：US20120289561A1
公开(公告)日：2012-11-15
申请号：US13467230
申请日：2012-05-09
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/222 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release fesoterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
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5.发明申请COMBINATIONS OF PROPIVERINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开丙肝和唾液乳液联合用于治疗过敏性叶片公开(公告)号：US20120289547A1
公开(公告)日：2012-11-15
申请号：US13468002
申请日：2012-05-09
IPC分类号： A61K31/445 , A61P13/10
CPC分类号： A61K31/445 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release propiverine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了包含治疗有效量的延长释放丙哌嗪或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。 本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放促丙素或其药学上可接受的盐和治疗有效量 毛果芸香碱或其药学上可接受的盐。 本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放素或药学上可接受的盐 以及治疗有效量的毛果芸香碱或其药学上可接受的盐。
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6.发明申请公开(公告)号：US20120289539A1
公开(公告)日：2012-11-15
申请号：US13476912
申请日：2012-05-21
IPC分类号： A61K31/439 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
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7.发明申请COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开用于治疗过敏性叶片的铁和唾液的组合公开(公告)号：US20120289529A1
公开(公告)日：2012-11-15
申请号：US13467244
申请日：2012-05-09
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了包含治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。 本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量 毛果芸香碱或其药学上可接受的盐。 本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐 以及治疗有效量的毛果芸香碱或其药学上可接受的盐。
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8.发明授权Combinations of solifenacin and salivary stimulants for the treatment of overactive bladder 有权用于治疗膀胱过度活动的索非那新和唾液兴奋剂的组合公开(公告)号：US09132124B2
公开(公告)日：2015-09-15
申请号：US13476883
申请日：2012-05-21
IPC分类号： A61K31/4178 , A61K31/4725
CPC分类号： A61K31/4178 , A61K31/4725 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了包含治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。 本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐和治疗有效量 毛果芸香碱或其药学上可接受的盐。 本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放索非那新或其药学上可接受的盐 以及治疗有效量的毛果芸香碱或其药学上可接受的盐。
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9.发明申请公开(公告)号：US20120289567A1
公开(公告)日：2012-11-15
申请号：US13476901
申请日：2012-05-21
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/4025 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release darifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release darifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release darifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
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10.发明申请COMBINATIONS OF TOLTERODINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开用于治疗过敏性叶片的铁妥黄素和唾液酸凝胶的组合公开(公告)号：US20120289560A1
公开(公告)日：2012-11-15
申请号：US13467177
申请日：2012-05-09
IPC分类号： A61K31/4178 , A61P13/10
CPC分类号： A61K31/137 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文公开了包含治疗有效量的延长释放托特罗定或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。 本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放托非罗定或其药学上可接受的盐和治疗有效量 毛果芸香碱或其药学上可接受的盐。 本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，该方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放托特罗定或其药学上可接受的盐 以及治疗有效量的毛果芸香碱或其药学上可接受的盐。
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