公开(公告)号：US4918105A

公开(公告)日：1990-04-17

申请号：US141072

申请日：1988-01-05

申请人： Terence Cartwright ,  Romaine Bouboutou-Tello ,  Yves Lelievre ,  Marie-Claude Fournier-Zaluski

发明人： Terence Cartwright ,  Romaine Bouboutou-Tello ,  Yves Lelievre ,  Marie-Claude Fournier-Zaluski

IPC分类号： C07C323/59 ,  A61K31/16 ,  A61P1/02 ,  A61P17/00 ,  A61P27/02 ,  A61P29/00 ,  A61P43/00 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C237/00 ,  C07C259/06 ,  C07C313/00

CPC分类号： A61K31/16 ,  C07C237/00

摘要： The present invention relates to a novel family of chemical compounds possessing a pharmacological activity, in particular a collagenase-inhibiting activity, a process for the production of these compounds and pharmaceutical compositions in which they are present.According to the invention, these compounds correspond to the general formula: ##STR1## in which: W represents an amino acid residue selected from the group comprising valine, lysine, norleucine and methionine, andZ represents an amino radical or an alkylamino radical of which the alkyl part, which contains 1 or 2 carbon atoms, is substituted by a phenyl or trifluorophenyl radical,and also include their diastereoisomers and their addition salts with pharmaceutically acceptable acids.The invention is applicable especially in the pharmaceutical industry.

摘要翻译： 本发明涉及具有药理活性，特别是胶原酶抑制活性的新型化合物族，这些化合物的制备方法和其中存在的药物组合物。 根据本发明，这些化合物对应于以下通式：其中：W表示选自缬氨酸，赖氨酸，正亮氨酸和甲硫氨酸的氨基酸残基，Z表示氨基或烷基氨基 其中含有1或2个碳原子的烷基部分被苯基或三氟苯基取代的基团，并且还包括它们的非对映异构体及其与药学上可接受的酸的加成盐。 本发明特别适用于制药工业。