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    Implantable arterio-venous shunt devices and methods for their use
    1.
    发明申请
    Implantable arterio-venous shunt devices and methods for their use 有权
    可植入的动静脉分流装置及其使用方法

    公开(公告)号：US20070299384A1

    公开(公告)日：2007-12-27

    申请号：US11789759

    申请日：2007-04-24

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61M5/00

    CPC分类号： A61F2/06 ,  A61B5/026 ,  A61B17/11 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device or creation of a fistula is provided that can be used as a therapeutic method for treating chronic obstructive pulmonary disease (COPD). The shunt device is implanted between an artery and a vein, preferably between a peripheral artery and the inferior vena cava. The shunt device and method of creating a fistula increases cardiac output and decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. Based on the effects of the method and device to the respiratory, cardiac and circulatory system, the method and device are beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供长期植入式动静脉分流装置或瘘管的产生，其可用作治疗慢性阻塞性肺病（COPD）的治疗方法。 分流装置植入动脉和静脉之间，优选植入外周动脉和下腔静脉之间。 创建瘘管的分流装置和方法增加心输出量并降低全身血管阻力，并且允许在植入后通过分流装置的血流速度至少为5ml / min。 基于方法和装置对呼吸，心脏和循环系统的影响，该方法和装置作为对与这些系统相关的问题或病症的患者的治疗是有益的。

    Implantable arterio-venous shunt devices and methods for their use
    2.
    发明授权
    Implantable arterio-venous shunt devices and methods for their use 有权
    可植入的动静脉分流装置及其使用方法

    公开(公告)号：US08574185B2

    公开(公告)日：2013-11-05

    申请号：US13101240

    申请日：2011-05-05

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61M19/00

    CPC分类号： A61F2/06 ,  A61B5/026 ,  A61B17/11 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device or creation of a fistula is provided that can be used as a therapeutic method for treating chronic obstructive pulmonary disease (COPD). The shunt device is implanted between an artery and a vein, preferably between a peripheral artery and the inferior vena cava. The shunt device and method of creating a fistula increases cardiac output and decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. Based on the effects of the method and device to the respiratory, cardiac and circulatory system, the method and device are beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供长期植入式动静脉分流装置或瘘管的产生，其可用作治疗慢性阻塞性肺病（COPD）的治疗方法。 分流装置植入动脉和静脉之间，优选植入外周动脉和下腔静脉之间。 创建瘘管的分流装置和方法增加心输出量并降低全身血管阻力，并且允许在植入后通过分流装置的血流速度至少为5ml / min。 基于方法和装置对呼吸，心脏和循环系统的影响，该方法和装置作为对与这些系统相关的问题或病症的患者的治疗是有益的。

    Therapeutic method for treatment of hypertension
    3.
    发明授权
    Therapeutic method for treatment of hypertension 有权
    治疗高血压的治疗方法

    公开(公告)号：US08551032B2

    公开(公告)日：2013-10-08

    申请号：US13654273

    申请日：2012-10-17

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61M19/00

    CPC分类号： A61F2/06 ,  A61B5/026 ,  A61B17/11 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device or creation of a fistula is provided that can be used as a therapeutic method for treating chronic obstructive pulmonary disease (COPD). The shunt device is implanted between an artery and a vein, preferably between a peripheral artery and the inferior vena cava. The shunt device and method of creating a fistula increases cardiac output and decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. Based on the effects of the method and device to the respiratory, cardiac and circulatory system, the method and device are beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供长期植入式动静脉分流装置或瘘管的产生，其可用作治疗慢性阻塞性肺病（COPD）的治疗方法。 分流装置植入动脉和静脉之间，优选植入外周动脉和下腔静脉之间。 创建瘘管的分流装置和方法增加心输出量并降低全身血管阻力，并且允许在植入后通过分流装置的血流速度至少为5ml / min。 基于方法和装置对呼吸，心脏和循环系统的影响，该方法和装置作为对与这些系统相关的问题或病症的患者的治疗是有益的。

    Long-Term Implantable Arterio-Venous Shunt Device
    4.
    发明申请
    Long-Term Implantable Arterio-Venous Shunt Device 审中-公开
    长期植入式动静脉分流装置

    公开(公告)号：US20120010556A1

    公开(公告)日：2012-01-12

    申请号：US13241497

    申请日：2011-09-23

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61M1/00

    CPC分类号： A61B17/11 ,  A61B5/026 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61F2/06 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device is provided that can be used as a therapeutic method. The shunt device is implanted between an artery and a vein, preferably between the aorta and the inferior vena cava. The shunt device decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. The blood flow rate could be controlled either via an open loop or a closed loop control means. The shunt device could also be a self-adjustable shunt device to self-adjust its structure to control the blood flow rate through its lumen. Based on the effects of the shunt device to the respiratory, cardiac and circulatory system, the implantable shunt device could be beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供可用作治疗方法的长期可植入动静脉分流装置。 分流装置植入动脉和静脉之间，优选在主动脉和下腔静脉之间。 分流装置降低全身血管阻力，并允许植入后通过分流装置的血流速度至少为5ml / min。 可以通过开环或闭环控制装置来控制血液流量。 分流装置也可以是自调节分流装置，以自我调节其结构以控制通过其管腔的血液流速。 基于分流装置对呼吸，心脏和循环系统的影响，可植入分流装置可作为对与这些系统相关的问题或病症的患者的治疗有益。

    IMPLANTABLE ARTERIO-VENOUS SHUNT DEVICES AND METHODS FOR THEIR USE
    5.
    发明申请
    IMPLANTABLE ARTERIO-VENOUS SHUNT DEVICES AND METHODS FOR THEIR USE 有权
    可植入式静脉穿刺装置及其使用方法

    公开(公告)号：US20110270149A1

    公开(公告)日：2011-11-03

    申请号：US13101240

    申请日：2011-05-05

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61M1/00

    CPC分类号： A61F2/06 ,  A61B5/026 ,  A61B17/11 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device or creation of a fistula is provided that can be used as a therapeutic method for treating chronic obstructive pulmonary disease (COPD). The shunt device is implanted between an artery and a vein, preferably between a peripheral artery and the inferior vena cava. The shunt device and method of creating a fistula increases cardiac output and decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. Based on the effects of the method and device to the respiratory, cardiac and circulatory system, the method and device are beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供长期植入式动静脉分流装置或瘘管的产生，其可用作治疗慢性阻塞性肺病（COPD）的治疗方法。 分流装置植入动脉和静脉之间，优选植入外周动脉和下腔静脉之间。 创建瘘管的分流装置和方法增加心输出量并降低全身血管阻力，并且允许在植入后通过分流装置的血流速度至少为5ml / min。 基于方法和装置对呼吸，心脏和循环系统的影响，该方法和装置作为对与这些系统相关的问题或病症的患者的治疗是有益的。

    Implantable arterio-venous shunt devices and methods for their use
    7.
    发明授权
    Implantable arterio-venous shunt devices and methods for their use 有权
    可植入的动静脉分流装置及其使用方法

    公开(公告)号：US07967769B2

    公开(公告)日：2011-06-28

    申请号：US11789759

    申请日：2007-04-24

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61M5/00

    CPC分类号： A61F2/06 ,  A61B5/026 ,  A61B17/11 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device or creation of a fistula is provided that can be used as a therapeutic method for treating chronic obstructive pulmonary disease (COPD). The shunt device is implanted between an artery and a vein, preferably between a peripheral artery and the inferior vena cava. The shunt device and method of creating a fistula increases cardiac output and decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. Based on the effects of the method and device to the respiratory, cardiac and circulatory system, the method and device are beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供长期植入式动静脉分流装置或瘘管的产生，其可用作治疗慢性阻塞性肺病（COPD）的治疗方法。 分流装置植入动脉和静脉之间，优选植入外周动脉和下腔静脉之间。 创建瘘管的分流装置和方法增加心输出量并降低全身血管阻力，并且允许在植入后通过分流装置的血流速度至少为5ml / min。 基于方法和装置对呼吸，心脏和循环系统的影响，该方法和装置作为对与这些系统相关的问题或病症的患者的治疗是有益的。

    Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases
    8.
    发明申请
    Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases 审中-公开
    使用抗增生剂治疗和预防肺增生性血管疾病

    公开(公告)号：US20050119330A1

    公开(公告)日：2005-06-02

    申请号：US10801729

    申请日：2004-03-15

    申请人： Peter Kao ,  Ronald Pearl ,  Toshihiko Nishimura ,  John Faul

    发明人： Peter Kao ,  Ronald Pearl ,  Toshihiko Nishimura ,  John Faul

    IPC分类号： A61K31/255 ,  A61K31/366 ,  A61K31/401

    CPC分类号： A61K31/255 ,  A61K31/366 ,  A61K31/401

    摘要： Methods of treating lung proliferative vascular disorders by administering an antiproliferative agent are provided. A preferred antiproliferative agent is a HMG-CoA reductase inhibitor, preferably simvastatin. Vascular occlusion in the pulmonary arteries of the patient is reduced as a result of the treatment through a reduction in neointimal hyperplasia and medial hypertrophy, and the restoration of normal endothelial cell function. The treatment also results in a reversal of right side cardiac hypertrophy. Lung proliferative vascular disorders that can be treated include primary pulmonary hypertension, secondary pulmonary hypertension, Eisenmenger's syndrome, chronic thromboembolic disease, pulmonary fibrosis, obliterative bronchiolitis, or lymphangioleiomyomatosis. Dosages and pharmaceutical formulations are provided.

    摘要翻译： 提供了通过施用抗增殖剂治疗肺增殖性血管疾病的方法。 优选的抗增殖剂是HMG-CoA还原酶抑制剂，优选为辛伐他汀。 作为通过减少新生内膜增生和内侧肥大的治疗以及恢复正常内皮细胞功能的结果，患者的肺动脉中的血管闭塞减少。 治疗也导致右侧心脏肥大的逆转。 可以治疗的肺增殖性血管疾病包括原发性肺动脉高压，继发性肺动脉高压，艾森曼格综合征，慢性血栓栓塞性疾病，肺纤维化，闭塞性细支气管炎或淋巴管平滑肌瘤病。 提供了剂量和药物制剂。

    Implantable arterio-venous shunt devices and methods for their use
    9.
    发明申请
    Implantable arterio-venous shunt devices and methods for their use 有权
    可植入的动静脉分流装置及其使用方法

    公开(公告)号：US20050107733A1

    公开(公告)日：2005-05-19

    申请号：US10961731

    申请日：2004-10-07

    申请人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    发明人： John Faul ,  Toshihiko Nishimura ,  Peter Kao ,  Ronald Pearl

    IPC分类号： A61B17/00 ,  A61B17/11 ,  A61F2/06 ,  A61F2/24 ,  A61M5/00

    CPC分类号： A61B17/11 ,  A61B5/026 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/1139 ,  A61F2/06 ,  A61M1/3653 ,  A61M1/3655 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2230/06 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/30

    摘要： A long-term implantable arterio-venous shunt device is provided that can be used as a therapeutic method. The shunt device is implanted between an artery and a vein, preferably between the aorta and the inferior vena cava. The shunt device decreases the systemic vascular resistance and allows a blood flow rate through the shunt device of at least 5 ml/min after the implantation. The blood flow rate could be controlled either via an open loop or a closed loop control means. The shunt device could also be a self-adjustable shunt device to self-adjust its structure to control the blood flow rate through its lumen. Based on the effects of the shunt device to the respiratory, cardiac and circulatory system, the implantable shunt device could be beneficial as a therapy to patients with problems or conditions related to these systems.

    摘要翻译： 提供了可用作治疗方法的长期可植入动静脉分流装置。 分流装置植入动脉和静脉之间，优选在主动脉和下腔静脉之间。 分流装置降低全身血管阻力，并允许植入后通过分流装置的血流速度至少为5ml / min。 可以通过开环或闭环控制装置来控制血液流量。 分流装置也可以是自调节分流装置，以自我调节其结构以控制通过其管腔的血液流速。 基于分流装置对呼吸，心脏和循环系统的影响，可植入分流装置可作为对与这些系统相关的问题或病症的患者的治疗有益。