公开(公告)号：US07592154B2

公开(公告)日：2009-09-22

申请号：US11498208

申请日：2006-08-01

申请人： Christine A. Miller ,  Ronen Mosseri ,  Stanley N. Cohen

发明人： Christine A. Miller ,  Ronen Mosseri ,  Stanley N. Cohen

IPC分类号： C12Q1/18 ,  C12Q1/02

CPC分类号： C12Q1/18 ,  C12Q1/6897 ,  G01N2800/44

摘要： Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiting steps in the SOS response pathway itself. SOS response induction can result from exposure of bacteria to certain antibiotics, including β-lactam antibiotics and other agents that affect cell wall synthesis. By transiently delaying bacterial cell division, SOS response induction interferes with bacterial killing by ordinarily lethal concentrations of these drugs A pharmaceutical composition comprising an SOS targeted agent is administered to a patient suffering from a microbial infection, in combination with an antibiotic that induces an SOS response. The identification of the SOS pathway as a target for modulating antibiotic action provides a basis for further therapeutic development, through screening assays designed to detect molecules or genes that act on these pathways.

摘要翻译： 提供了组合物和方法，用于在抗微生物制剂中使用SOS途径靶向剂。 通过破坏通常激活细菌SOS反应或通过抑制SOS反应途径本身的步骤的机制，细菌对抗生素的天生敏感性增加。 SOS反应诱导可能是由细菌暴露于某些抗生素，包括β-内酰胺抗生素和影响细胞壁合成的其他药物引起的。 通过暂时延迟细菌细胞分裂，SOS反应诱导通过这些药物的通常致死浓度干扰细菌杀伤。将包含SOS靶向药物的药物组合物施用于患有微生物感染的患者与引起SOS反应的抗生素组合 。 作为调节抗生素作用靶标的SOS途径的鉴定为进一步治疗发展提供了依据，通过设计用于检测作用于这些途径的分子或基因的筛选试验。

公开(公告)号：US20070031874A1

公开(公告)日：2007-02-08

申请号：US11498208

申请日：2006-08-01

申请人： Christine Miller ,  Ronen Mosseri ,  Stanley Cohen

发明人： Christine Miller ,  Ronen Mosseri ,  Stanley Cohen

IPC分类号： C12Q1/68 ,  C12Q1/18 ,  A61K31/43 ,  A61K31/545

CPC分类号： C12Q1/18 ,  C12Q1/6897 ,  G01N2800/44

摘要： Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiting steps in the SOS response pathway itself. SOS response induction can result from exposure of bacteria to certain antibiotics, including β-lactam antibiotics and other agents that affect cell wall synthesis. By transiently delaying bacterial cell division, SOS response induction interferes with bacterial killing by ordinarily lethal concentrations of these drugs A pharmaceutical composition comprising an SOS targeted agent is administered to a patient suffering from a microbial infection, in combination with an antibiotic that induces an SOS response. The identification of the SOS pathway as a target for modulating antibiotic action provides a basis for further therapeutic development, through screening assays designed to detect molecules or genes that act on these pathways.

摘要翻译： 提供了组合物和方法，用于在抗微生物制剂中使用SOS途径靶向剂。 通过破坏通常激活细菌SOS反应或通过抑制SOS反应途径本身的步骤的机制，细菌对抗生素的天生敏感性增加。 SOS反应诱导可能是由细菌暴露于某些抗生素，包括β-内酰胺抗生素和影响细胞壁合成的其他药物引起的。 通过暂时延迟细菌细胞分裂，SOS反应诱导通过这些药物的通常致死浓度干扰细菌杀伤。将包含SOS靶向药物的药物组合物施用于患有微生物感染的患者与引起SOS反应的抗生素组合 。 作为调节抗生素作用靶标的SOS途径的鉴定为进一步治疗发展提供了依据，通过设计用于检测作用于这些途径的分子或基因的筛选试验。