公开(公告)号：US20060198818A1

公开(公告)日：2006-09-07

申请号：US11072763

申请日：2005-03-04

申请人： Ross Wallingford ,  Maciej Turowski

发明人： Ross Wallingford ,  Maciej Turowski

IPC分类号： A61K31/765

CPC分类号： G01N30/88 ,  A61K47/60 ,  G01N2030/8813 ,  G01N2030/8854 ,  Y10T436/200833 ,  Y10T436/2575

摘要： A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an interger greater than 10. The method includes the step of chromatographing a sample of the mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)n H, RO(C2H4O)nA, and AO(C2H4O)nA in the mixture. In addition a a chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a biologically active material and n is an interger greater than 10. The method includes two steps. The first step is derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD, wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD in the derivatized mixture.

公开(公告)号：US20060045866A1

公开(公告)日：2006-03-02

申请号：US10932629

申请日：2004-09-01

申请人： Chris Chappelow ,  Edward Daugs ,  Sterling Gatling ,  Kevin Sikkema ,  Maciej Turowski ,  Ross Wallingford

发明人： Chris Chappelow ,  Edward Daugs ,  Sterling Gatling ,  Kevin Sikkema ,  Maciej Turowski ,  Ross Wallingford

IPC分类号： A61K31/765 ,  C08G65/32

CPC分类号： C08G65/30 ,  C08G65/329

摘要： The invention is directed toward novel high molecular weight and high purity mPEG alcohol compositions as well as a process for obtaining said compositions by removing PEG diols from the mPEG alcohol after polymerization is complete.

摘要翻译： 本发明涉及新的高分子量和高纯度mPEG醇组合物，以及通过在聚合完成后从mPEG醇中除去PEG二醇获得所述组合物的方法。