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    Method for analyzing activated polyethylene glycol compounds
    3.
    发明申请
    Method for analyzing activated polyethylene glycol compounds 失效

    公开(公告)号：US20060198818A1

    公开(公告)日：2006-09-07

    申请号：US11072763

    申请日：2005-03-04

    申请人： Ross Wallingford ,  Maciej Turowski

    发明人： Ross Wallingford ,  Maciej Turowski

    IPC分类号： A61K31/765

    CPC分类号： G01N30/88 ,  A61K47/60 ,  G01N2030/8813 ,  G01N2030/8854 ,  Y10T436/200833 ,  Y10T436/2575

    摘要： A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an interger greater than 10. The method includes the step of chromatographing a sample of the mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)n H, RO(C2H4O)nA, and AO(C2H4O)nA in the mixture. In addition a a chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a biologically active material and n is an interger greater than 10. The method includes two steps. The first step is derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD, wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD in the derivatized mixture.

    METHOD FOR ANALYZING ACTIVATED POLYETHYLENE GLYCOL COMPOUNDS
    4.
    发明申请
    METHOD FOR ANALYZING ACTIVATED POLYETHYLENE GLYCOL COMPOUNDS 失效
    分析活性聚乙烯甘油化合物的方法

    公开(公告)号：US20120125852A1

    公开(公告)日：2012-05-24

    申请号：US13280790

    申请日：2011-10-25

    申请人： Ross A. Wallingford ,  Maciej Turowski

    发明人： Ross A. Wallingford ,  Maciej Turowski

    IPC分类号： B01D15/08

    CPC分类号： G01N30/88 ,  A61K47/60 ,  G01N2030/8813 ,  G01N2030/8854 ,  Y10T436/200833 ,  Y10T436/2575

    摘要： A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an integer greater than 10. The method includes the derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD, wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD in the derivatized mixture.

    摘要翻译： 用于在其混合物中测定RO（CH 2 CH 2 O）n H，RO（C 2 H 4 O）n A和AO（C 2 H 4 O）n A）的化学分析方法，其中R是烷基，A是与表面偶联的官能团 生物活性物质或另一种使用的物质，n是大于10的整数。该方法包括用衍生剂衍生化A组混合物以形成衍生化的混合物，其包含RO（CH 2 CH 2 O）nH，RO（C 2 H 4 O）n AD， 和DAO（C2H4O）nAD，其中AD是衍生的A基团。 第二步是在临界条件下通过液相色谱法对衍生化混合物的样品进行色谱分析，以确定衍生化混合物中RO（CH2CH2O）nH，RO（C2H4O）nAD和DAO（C2H4O）nAD的相对量。

    Method for analyzing activated polyethylene glycol compounds
    7.
    发明授权
    Method for analyzing activated polyethylene glycol compounds 失效
    分析活性聚乙二醇化合物的方法

    公开(公告)号：US08202732B2

    公开(公告)日：2012-06-19

    申请号：US13280790

    申请日：2011-10-25

    申请人： Ross A Wallingford ,  Maciej Turowski

    发明人： Ross A Wallingford ,  Maciej Turowski

    IPC分类号： G01N33/00

    CPC分类号： G01N30/88 ,  A61K47/60 ,  G01N2030/8813 ,  G01N2030/8854 ,  Y10T436/200833 ,  Y10T436/2575

    摘要： A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an integer greater than 10. The method includes derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD, wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD in the derivatized mixture.

    摘要翻译： 用于在其混合物中测定RO（CH 2 CH 2 O）n H，RO（C 2 H 4 O）n A和AO（C 2 H 4 O）n A）的化学分析方法，其中R是烷基，A是与表面偶联的官能团 生物活性物质或另一种使用的物质，n是大于10的整数。该方法包括用衍生剂衍生化A组的混合物，以形成衍生的混合物，其包含RO（CH 2 CH 2 O）nH，RO（C 2 H 4 O）n AD和 DAO（C2H4O）nAD，其中AD是衍生的A组。 第二步是在临界条件下通过液相色谱法对衍生化混合物的样品进行色谱分析，以确定衍生化混合物中RO（CH2CH2O）nH，RO（C2H4O）nAD和DAO（C2H4O）nAD的相对量。