公开(公告)号：US08580762B2

公开(公告)日：2013-11-12

申请号：US13310157

申请日：2011-12-02

申请人： Edward James Olhava ,  Richard Chesworth ,  Kevin Wayne Kuntz ,  Victoria M. Richon ,  Roy Macfarlane Pollock ,  Scott Richard Daigle

发明人： Edward James Olhava ,  Richard Chesworth ,  Kevin Wayne Kuntz ,  Victoria M. Richon ,  Roy Macfarlane Pollock ,  Scott Richard Daigle

IPC分类号： A61K31/70 ,  C07H19/00

CPC分类号： A61K31/7076 ,  A61K31/519 ,  A61K31/52 ,  A61K31/7064 ,  C07D473/34 ,  C07D487/04 ,  C07H19/14 ,  C07H19/16

摘要： The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.