公开(公告)号：US4772288A

公开(公告)日：1988-09-20

申请号：US62027

申请日：1987-06-15

申请人： William H. Borner ,  Marcel E. Nimni ,  Rudy C. Shepard

发明人： William H. Borner ,  Marcel E. Nimni ,  Rudy C. Shepard

IPC分类号： A61L27/36 ,  A61L17/00

CPC分类号： A61L27/3662 ,  A61L27/3683 ,  A61L2430/10 ,  Y10S623/917

摘要： A method of making implantable ligament and tendon prostheses from natural collagen-containing tissues is described. The tissues used are those wherein the collagen fibers are aligned in one direction such as in ligaments or tendons. The method comprises disrupting the interfibrillar matrix physically by mechanical means such as a roller or rollers in order to generate an expanded network of fibers that are more easily further treated chemically and which also generate a more favorable substrate for tissue ingrowth after implantation. Prostheses made from separated collagen fiber bundles which retain their natural configuration and length (as opposed to reconstituted collagen), exhibit improved softness and flexibility when compared with prostheses made from conventional chemically fixed (e.g., glutaraldehyde cross-linked) tendons which have not been separated as described herein. Another implementation of the developed new technology allows for the formation of composites between the dissociated collagen fibers involving two or more tissues or between collagen and synthetic fibers. These composites can also include absorbable materials.

摘要翻译： 描述了从含有天然胶原的组织制备可植入韧带和腱假体的方法。 使用的组织是其中胶原纤维在一个方向上对齐的组织，例如在韧带或腱中。 该方法包括通过诸如辊或辊之类的机械装置物理地干扰纤维素基质，以便产生更容易进一步化学处理的纤维的扩展网络，并且还可以在植入后产生用于组织向内生长的更有利的底物。 与从未分离的常规化学固定（例如戊二醛交联）腱制成的假体相比，保留其自然构型和长度（与复原胶原相反）的分离的胶原纤维束制成的假肢显示出改善的柔软性和柔韧性。 如本文所述。 开发的新技术的另一实施方式允许在涉及两个或更多个组织或胶原与合成纤维之间的解离的胶原纤维之间形成复合物。 这些复合材料也可以包括可吸收材料。