公开(公告)号：US20170204149A1

公开(公告)日：2017-07-20

申请号：US15321246

申请日：2015-06-19

申请人： Rajiv CHOPRA ,  Norio HAMAMATSU ,  Ryan Scott STREEPER ,  Brian Edward VASH

发明人： Rajiv CHOPRA ,  Norio HAMAMATSU ,  Ryan Scott STREEPER ,  Brian Edward VASH

IPC分类号： C07K14/495 ,  C07K14/765

CPC分类号： C07K14/495 ,  A61K38/00 ,  C07K14/4756 ,  C07K14/765 ,  C07K2319/31

摘要： The disclosure relates to fusion polypeptides comprising serum albumin or a functional variant thereof and GDF15 protein or a functional variant thereof and to pharmaceutical compositions that contain the fusion polypeptides, nucleic acids that encode the fusion polypeptides, methods of making the polypeptides and use of the polypeptides to decreasing appetite, decreasing body weight and treating metabolic diseases.

公开(公告)号：US20190135908A1

公开(公告)日：2019-05-09

申请号：US16096579

申请日：2017-04-26

申请人： Hong CHEN ,  Rajiv CHOPRA ,  Seung Wan HAHM ,  Norio HAMAMATSU ,  Ryan Scott STREEPER ,  Mei XU ,  NOVARTIS AG

发明人： Hong CHEN ,  Rajiv CHOPRA ,  Seung Wan HAHM ,  Norio HAMAMATSU ,  Ryan Scott STREEPER ,  Mei XU

IPC分类号： C07K16/22

摘要： Provided herein are monoclonal antibodies (e.g., human antibodies) binding to human Growth Differentiation Factor 15 protein (hereinafter, sometimes referred to as “GDF15”), and pharmaceutical compositions and methods of treatment comprising the same.