公开(公告)号：US06451831B1

公开(公告)日：2002-09-17

申请号：US10074772

申请日：2002-02-12

申请人： Kazuharu Ienaga ,  Hiroki Mikami ,  Ryoji Nishibata

发明人： Kazuharu Ienaga ,  Hiroki Mikami ,  Ryoji Nishibata

IPC分类号： A61K31415

CPC分类号： A61K31/4166

摘要： A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, a hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. Administration of the compounds substantially increases the serum albumin value of patients suffering from hypoalbuminaemia from abnormal values, and significantly improves the condition of hypoalbuminaemia.

摘要翻译： 用于低白蛋白血症的高度安全和有用的治疗剂含有由式（I）表示的乙内酰脲衍生物或其药学上可接受的盐作为有效成分：其中R 1和R 2可以相同或不同，表示氢， 烷基或环烷基; X和Y各自可以相同或不同，表示氢，羟基，烷基或烷氧基，或X和Y一起表示氧代基。 化合物的施用显着提高了患有低蛋白血症的患者的血清白蛋白值异常值，并显着改善了低白蛋白血症的状况。

公开(公告)号：US5602302A

公开(公告)日：1997-02-11

申请号：US175740

申请日：1993-12-30

申请人： Hiroki Mikami ,  Ryoji Nishibata

发明人： Hiroki Mikami ,  Ryoji Nishibata

IPC分类号： A01K67/027 ,  C12N15/00 ,  A61K49/00

CPC分类号： A01K67/027

摘要： The present invention relates to a method of preparing bronchial hypersensitive or hyposensitive guinea pigs by selective breeding on the basis of bronchial sensitivity to inhalant chemicals inducing bronchoconstriction. The hypersensitive guinea pigs of the present invention are extremely useful as model animals for the study of bronchial asthma and allergic rhinitis and for the evaluation of efficacy of-antiasthmatics and antiallergic substances.

摘要翻译： 本发明涉及一种通过选择性繁殖来制备支气管超敏感或低敏感性豚鼠的方法，其基于支气管对吸入性药物诱发支气管收缩的敏感性。 本发明的过敏性豚鼠作为用于研究支气管哮喘和过敏性鼻炎的模型动物以及用于评估抗哮喘和抗过敏物质的功效的非常有用。