公开(公告)号：US20120282172A1

公开(公告)日：2012-11-08

申请号：US13467178

申请日：2012-05-09

申请人： João Nuno Sereno de Almeida Moreira ,  Vera Lúcia Dantas Nunes Caldeira de Moura ,  Sérgio Paulo de Magalhães Simões ,  Maria da Conceição Monteiro Pedroso de Lima

发明人： João Nuno Sereno de Almeida Moreira ,  Vera Lúcia Dantas Nunes Caldeira de Moura ,  Sérgio Paulo de Magalhães Simões ,  Maria da Conceição Monteiro Pedroso de Lima

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K9/107 ,  A61K31/704 ,  A61K51/12 ,  A61K31/675 ,  A61K31/196 ,  A61K31/198 ,  A61K31/255 ,  A61K31/175 ,  A61K31/131 ,  A61K31/565 ,  A61K31/047 ,  A61K31/519 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/517 ,  A61K31/52 ,  A61K31/475 ,  A61K33/24 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/616 ,  A61K38/17 ,  A61K38/57 ,  A61P35/00 ,  A61P31/00 ,  A61P29/00 ,  A61P9/00 ,  G01N21/64 ,  A61K49/00

CPC分类号： A61K47/48246 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/00 ,  A61K31/704 ,  A61K47/64 ,  A61K47/6911 ,  C07K14/4702 ,  C07K2319/33

摘要： The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

摘要翻译： 本发明提供了一种系统，其通过特异性靶向在靶器官（例如肿瘤细胞和/或肿瘤血管的血管细胞）中的特定细胞表面上过表达的受体的配体。 此外，本发明提供了一种方法，其中在靶细胞内部化先前提及的系统之后，以相关药剂的高速率触发释放，允许有效的细胞内递送，并因此使运送货物的浓度增加 目标网站。 总之，本发明提供了一种诊断，预防和治疗人类疾病和病症的方法。

公开(公告)号：US08231895B2

公开(公告)日：2012-07-31

申请号：US12153649

申请日：2008-05-22

申请人： João Nuno Sereno de Almeida Moreira ,  Vera Lúcia Dantas Nunes Caldeira de Moura ,  Sérgio Paulo de Magalhães Simões ,  Maria da Conceição Monteiro Pedroso de Lima

发明人： João Nuno Sereno de Almeida Moreira ,  Vera Lúcia Dantas Nunes Caldeira de Moura ,  Sérgio Paulo de Magalhães Simões ,  Maria da Conceição Monteiro Pedroso de Lima

IPC分类号： A61K9/12

CPC分类号： A61K47/48246 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/00 ,  A61K31/704 ,  A61K47/64 ,  A61K47/6911 ,  C07K14/4702 ,  C07K2319/33

摘要： The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.

摘要翻译： 本发明提供了一种系统，其通过特异性靶向在靶器官（例如肿瘤细胞和/或肿瘤血管的血管细胞）中的特定细胞表面上过表达的受体的配体。 此外，本发明提供了一种方法，其中在靶细胞内部化先前提及的系统之后，以相关药剂的高速率触发释放，允许有效的细胞内递送，并因此使运送货物的浓度增加 目标网站。 总之，本发明提供了一种诊断，预防和治疗人类疾病和病症的方法。