公开(公告)号：US20200308206A1

公开(公告)日：2020-10-01

申请号：US16770087

申请日：2018-02-08

申请人： SHENZHEN CATALYS SCIENCE AND TECHNOLOGY CO., LTD.

发明人： Xumu ZHANG ,  Genqiang CHEN ,  Jiaming HUANG

IPC分类号： C07F15/00 ,  C07F9/6561 ,  C07C51/36 ,  B01J31/22 ,  B01J31/24

摘要： The present invention relates to the technical field of chiral synthesis, and specifically provides a new type of oxa-spirodiphosphine ligands. The bisphosphine ligand is prepared with oxa-spirobisphenol as a starting material after triflation, palladium catalyzed coupling with diaryl phosphine oxide, reduction of trichlorosilane, further palladium catalyzed coupling with diaryl phosphine oxide, and further reduction of trichlorosilane. The oxa-spiro compound has central chirality, and thus includes L-oxa-spirodiphosphine ligand and R-oxa-spirodiphosphine ligand. The racemic spirodiphosphine ligand is capable of being synthesized from racemic oxa-spirobisphenol as a raw material. The present invention can be used as a chiral ligand in the asymmetric hydrogenation of unsaturated carboxylic adds. The complex of the ligand with ruthenium can achieve an enantioselectivity of greater than 99% in the asymmetric hydrogenation of methyl-cinnamic acid.