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公开(公告)号：US20180251472A1
公开(公告)日：2018-09-06
申请号：US15757109
申请日：2016-09-02
发明人： Jei Man RYU , Dong Won LEE , Kang Hyeok LEE , Jin Hun PARK , Geum Sil CHO , Ki Sung LEE , Jin Ho CHUNG , Woo Ile PARK , Jae Young LEE
IPC分类号： C07D495/04 , C07D261/20 , C07D295/073 , C07D333/36 , C07C235/46 , C07D213/56 , C07D209/18 , C07D231/40 , C07D309/38 , C07D295/192 , C07C235/56 , C07D213/81 , C07D213/66 , C07C235/48 , C07D333/24 , A61P7/02
摘要： The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel platelet aggregation inhibitor specifically inhibiting shear stress-induced platelet aggregation; a pharmaceutical composition containing the same as an active ingredient; and a preparation method therefor.
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公开(公告)号：US10730886B2
公开(公告)日：2020-08-04
申请号：US15757109
申请日：2016-09-02
发明人： Jei Man Ryu , Dong Won Lee , Kang Hyeok Lee , Jin Hun Park , Geum Sil Cho , Ki Sung Lee , Jin Ho Chung , Woo Ile Park , Jae Young Lee
IPC分类号： C07D495/04 , C07D261/20 , C07D413/04 , A61K31/4365 , A61K31/5375 , A61K31/423 , A61P7/02 , C07C235/46 , C07C235/48 , C07C235/56 , C07D209/18 , C07D213/56 , C07D213/66 , C07D213/81 , C07D231/40 , C07D295/073 , C07D295/192 , C07D309/38 , C07D333/24 , C07D333/36
摘要： The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel platelet aggregation inhibitor specifically inhibiting shear stress-induced platelet aggregation; a pharmaceutical composition containing the same as an active ingredient; and a preparation method therefor.
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3.发明申请公开(公告)号：US20230132036A1
公开(公告)日：2023-04-27
申请号：US17914425
申请日：2021-03-25
发明人： Jei Man RYU , Chung JU , Hyun Kyu CHUNG , Geum Sil CHO
IPC分类号： A61K31/4745 , A61K31/366 , A61K45/06 , A61P31/14
摘要： The present invention relates to a use of pyronaridine or a pharmaceutically acceptable salt thereof, and/or artemisinin or a derivative thereof for preventing or treating an epidemic RNA viral infectious disease, and more specifically, to a pharmaceutical composition for preventing or treating an epidemic RNA viral infectious disease, in particular, Coronavirus Disease 2019 (COVID-19), the composition comprising a therapeutically effective amount of pyronaridine or a pharmaceutically acceptable salt thereof, and/or artemisinin or a derivative thereof, together with a pharmaceutically acceptable carrier.
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公开(公告)号：US20190015339A1
公开(公告)日：2019-01-17
申请号：US16066712
申请日：2016-12-28
发明人： Jei-Man RYU , Woo-Ile PARK , Kyoung-Hwan KANG , Woo-Kyung KIM , Ah-Reum CHAE , Soo-Won KIM , Hyun-Woo JUNG , Jae-Young LEE
IPC分类号： A61K9/20 , A61K31/4184 , A61K31/4418 , A61K9/24
摘要： The present invention relates to a tablet comprising candesartan or candesartan cilexetil and amlodipine or its pharmaceutically acceptable salt as active ingredients, the tablet using a particular solubilizer in order to significantly improve the stability and dissolution properties of the active ingredients. In addition, the present invention relates to a method of preparing the tablet.
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