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![Crystalline form of 1'-(1-methylethyl)-4'-[(2-fluoro-4-methoxyphenyl)methyl]-5'-methyl-1H-pyrazol-3'-O-beta-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments](/abs-image/US/2007/10/18/US20070244176A1/abs.jpg.150x150.jpg)
1.发明申请Crystalline form of 1'-(1-methylethyl)-4'-[(2-fluoro-4-methoxyphenyl)methyl]-5'-methyl-1H-pyrazol-3'-O-beta-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D-吡喃葡萄糖苷的结晶形式， 用于其制备和用于制备药物的用途公开(公告)号：US20070244176A1
公开(公告)日：2007-10-18
申请号：US11621859
申请日：2007-01-10
申请人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
发明人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
IPC分类号： A61K31/415 , C07D231/00
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D - 吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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![CRYSTALLINE FORM OF 1' -(1-METHYLETHYL)-4' -[(2-FLUORO-4-METHOXYPHENYL)METHYL]-5' -METHYL-1H-PYRAZOL-3' -O-BETA-D-GLUCOPYRANOSIDE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS](/abs-image/US/2009/07/16/US20090181905A1/abs.jpg.150x150.jpg)
2.发明申请CRYSTALLINE FORM OF 1' -(1-METHYLETHYL)-4' -[(2-FLUORO-4-METHOXYPHENYL)METHYL]-5' -METHYL-1H-PYRAZOL-3' -O-BETA-D-GLUCOPYRANOSIDE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O- BETA-D-吡喃葡萄糖苷的晶体形式，方法 由于其制备及其用于制备药物的用途公开(公告)号：US20090181905A1
公开(公告)日：2009-07-16
申请号：US12404442
申请日：2009-03-16
申请人： Gerd KRAEMER , Hans-Juergen MARTIN , Gebhard ADELGOSS , Klaus DUGI , Adil DURAN , Peter EICKELMANN , Steffen MAIER , Sabine PINNETTI , Regine RITTER , Gebhard SCHILCHER , Ruediger STREICHER , Leo THOMAS
发明人： Gerd KRAEMER , Hans-Juergen MARTIN , Gebhard ADELGOSS , Klaus DUGI , Adil DURAN , Peter EICKELMANN , Steffen MAIER , Sabine PINNETTI , Regine RITTER , Gebhard SCHILCHER , Ruediger STREICHER , Leo THOMAS
IPC分类号： A61K31/7052 , C07H17/02 , A61P3/00
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D - 吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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3.发明申请Methods for preventing and treating metabolic disorders and new pyrazole-O-glycoside derivatives 审中-公开用于预防和治疗代谢紊乱和新的吡唑-O-糖苷衍生物的方法公开(公告)号：US20070072813A1
公开(公告)日：2007-03-29
申请号：US11495332
申请日：2006-07-28
申请人： Frank Himmelsbach , Roland Maier , Peter Eickelmann , Leo Thomas , Edward Barsoumian , Klaus Dugi , Sabine Pinnetti , Regine Ritter , Ruediger Streicher , Koichi Fujita , Toshihiro Hatanaka , Nozomu Ishida , Katsumi Maezono , Koji Ohsumi
发明人： Frank Himmelsbach , Roland Maier , Peter Eickelmann , Leo Thomas , Edward Barsoumian , Klaus Dugi , Sabine Pinnetti , Regine Ritter , Ruediger Streicher , Koichi Fujita , Toshihiro Hatanaka , Nozomu Ishida , Katsumi Maezono , Koji Ohsumi
IPC分类号： A61K31/7052 , C07H17/02
CPC分类号： A61K31/7056 , C07H17/02
摘要： The invention relates to methods for preventing or treating metabolic disorders, for improving glycemic control, for preventing progression from impaired glucose tolerance, insulin resistance and/or from metabolic syndrome to type 2 diabetes mellitus, for preventing or treating of complications of diabetes mellitus, for reducing the weight, for preventing or treating the degeneration of pancreatic beta cells, for treating hyperinsulinemia and insulin resistance and diabetes type 1, in patients in need thereof by administering a pharmaceutical composition comprising a pyrazole-O-glycoside as defined in claim 1, or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及用于预防或治疗代谢紊乱，用于改善血糖控制，预防糖耐量受损，胰岛素抵抗和/或从代谢综合征到2型糖尿病的预防或治疗糖尿病并发症的方法，用于 通过施用包含权利要求1所定义的吡唑-O-糖苷的药物组合物，减少用于预防或治疗胰腺β细胞变性，用于治疗有需要的患者中的高胰岛素血症和胰岛素抵抗和1型糖尿病，或 其前药，或其药学上可接受的盐。
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4.发明申请公开(公告)号：US20100317575A1
公开(公告)日：2010-12-16
申请号：US12521644
申请日：2008-01-18
申请人： Sabine Pinnetti , Ruediger Streicher , Leo Thomas , Klaus Dugi
发明人： Sabine Pinnetti , Ruediger Streicher , Leo Thomas , Klaus Dugi
IPC分类号： A61K31/7056 , A61P3/10 , A61K38/28 , A61K38/26 , A61K38/16 , A61K38/22 , A61P3/04 , A61P27/12 , A61P9/00 , A61P9/10
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0031 , A61K9/02 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K9/2072 , A61K9/4858 , A61K31/7056 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition comprising a pyrazole-O-glucoside derivative selected from the group of compounds (1) to (29) according to claim 1 in combination with at least one second therapeutic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
摘要翻译： 本发明涉及一种药物组合物，其包含选自根据权利要求1的化合物（1）至（29）的组合的至少一种第二治疗剂的吡唑-O-葡萄糖苷衍生物，其适用于治疗或预防 选自1型糖尿病，2型糖尿病，葡萄糖耐量异常和高血糖的一种或多种病症。 此外，本发明涉及用于预防或治疗代谢紊乱及相关病症的方法。
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![Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments](/abs-image/US/2010/11/23/US07838500B2/abs.jpg.150x150.jpg)
5.发明授权Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-基-O-葡萄糖-D-吡喃葡糖苷的结晶形式 其制备方法及其制备药物的用途公开(公告)号：US07838500B2
公开(公告)日：2010-11-23
申请号：US12404442
申请日：2009-03-16
申请人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
发明人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-基] D-吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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![Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments](/abs-image/US/2009/04/28/US07524822B2/abs.jpg.150x150.jpg)
6.发明授权Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D-吡喃葡萄糖苷的结晶形式， 用于其制备和用于制备药物的用途公开(公告)号：US07524822B2
公开(公告)日：2009-04-28
申请号：US11621859
申请日：2007-01-10
申请人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
发明人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D - 吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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