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![Crystalline form of 1'-(1-methylethyl)-4'-[(2-fluoro-4-methoxyphenyl)methyl]-5'-methyl-1H-pyrazol-3'-O-beta-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments](/abs-image/US/2007/10/18/US20070244176A1/abs.jpg.150x150.jpg)
1.发明申请Crystalline form of 1'-(1-methylethyl)-4'-[(2-fluoro-4-methoxyphenyl)methyl]-5'-methyl-1H-pyrazol-3'-O-beta-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D-吡喃葡萄糖苷的结晶形式， 用于其制备和用于制备药物的用途公开(公告)号：US20070244176A1
公开(公告)日：2007-10-18
申请号：US11621859
申请日：2007-01-10
申请人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
发明人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
IPC分类号： A61K31/415 , C07D231/00
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D - 吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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2.发明授权Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis 有权聚氨酯，硫代和二硫代类似物及其作为胆固醇生物合成抑制剂的用途公开(公告)号：US06346545B1
公开(公告)日：2002-02-12
申请号：US09275318
申请日：1999-03-24
申请人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Adelgoss , Gebhard Schilcher
发明人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Adelgoss , Gebhard Schilcher
IPC分类号： A61K3127
CPC分类号： C07D295/135 , C07C271/24 , C07C271/56 , C07C333/06 , C07C333/24 , C07C2601/14 , Y02P20/55
摘要： The present invention relates to urethanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
摘要翻译： 本发明涉及聚氨酯，其一般形式的n，A，X，Y和R 1至R 8的硫代和二硫类似物如权利要求1中所定义，其对映异构体，非对映异构体及其盐，特别是生理上可接受的酸加成 其具有有价值的性质，特别是对胆固醇生物合成的抑制作用，含有这些化合物的药物组合物，其用途和制备方法。
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![Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments](/abs-image/US/2010/11/23/US07838500B2/abs.jpg.150x150.jpg)
3.发明授权Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-基-O-葡萄糖-D-吡喃葡糖苷的结晶形式 其制备方法及其制备药物的用途公开(公告)号：US07838500B2
公开(公告)日：2010-11-23
申请号：US12404442
申请日：2009-03-16
申请人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
发明人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-基] D-吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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![Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments](/abs-image/US/2009/04/28/US07524822B2/abs.jpg.150x150.jpg)
4.发明授权Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D-吡喃葡萄糖苷的结晶形式， 用于其制备和用于制备药物的用途公开(公告)号：US07524822B2
公开(公告)日：2009-04-28
申请号：US11621859
申请日：2007-01-10
申请人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
发明人： Gerd Kraemer , Hans-Juergen Martin , Gebhard Adelgoss , Klaus Dugi , Adil Duran , Peter Eickelmann , Steffen Maier , Sabine Pinnetti , Regine Ritter , Gebhard Schilcher , Ruediger Streicher , Leo Thomas
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D - 吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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![CRYSTALLINE FORM OF 1' -(1-METHYLETHYL)-4' -[(2-FLUORO-4-METHOXYPHENYL)METHYL]-5' -METHYL-1H-PYRAZOL-3' -O-BETA-D-GLUCOPYRANOSIDE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS](/abs-image/US/2009/07/16/US20090181905A1/abs.jpg.150x150.jpg)
5.发明申请CRYSTALLINE FORM OF 1' -(1-METHYLETHYL)-4' -[(2-FLUORO-4-METHOXYPHENYL)METHYL]-5' -METHYL-1H-PYRAZOL-3' -O-BETA-D-GLUCOPYRANOSIDE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS 失效1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O- BETA-D-吡喃葡萄糖苷的晶体形式，方法 由于其制备及其用于制备药物的用途公开(公告)号：US20090181905A1
公开(公告)日：2009-07-16
申请号：US12404442
申请日：2009-03-16
申请人： Gerd KRAEMER , Hans-Juergen MARTIN , Gebhard ADELGOSS , Klaus DUGI , Adil DURAN , Peter EICKELMANN , Steffen MAIER , Sabine PINNETTI , Regine RITTER , Gebhard SCHILCHER , Ruediger STREICHER , Leo THOMAS
发明人： Gerd KRAEMER , Hans-Juergen MARTIN , Gebhard ADELGOSS , Klaus DUGI , Adil DURAN , Peter EICKELMANN , Steffen MAIER , Sabine PINNETTI , Regine RITTER , Gebhard SCHILCHER , Ruediger STREICHER , Leo THOMAS
IPC分类号： A61K31/7052 , C07H17/02 , A61P3/00
CPC分类号： C07H17/02
摘要： The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
摘要翻译： 本发明涉及1' - （1-甲基乙基）-4' - [（2-氟-4-甲氧基苯基）甲基] -5'-甲基-1H-吡唑-3'-O-β-D - 吡喃葡萄糖苷，其制备方法，以及其用于制备药物的用途。
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6.发明授权Urethanes derived from azacycloalkanes, the thio and dithio analogues thereof and their use as cholesterol biosynthesis inhibitors 有权衍生自氮杂环烷烃的聚氨酯，其硫代和二硫类似物及其作为胆固醇生物合成抑制剂的用途公开(公告)号：US06339096B1
公开(公告)日：2002-01-15
申请号：US09275317
申请日：1999-03-24
申请人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Schilcher , Gebhard Adelgoss
发明人： Roland Maier , Rudolf Hurnaus , Michael Mark , Bernhard Eisele , Peter Mueller , Gebhard Schilcher , Gebhard Adelgoss
IPC分类号： A61K31445
CPC分类号： C07D211/70 , C07D211/26 , C07D211/32 , C07D211/54
摘要： The present invention relates to urethanes derived from azacycloalkanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y, E and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
摘要翻译： 本发明涉及衍生自氮杂环烷烃的氨基甲酸酯及其一般形式的n，A，X，Y，E和R 1至R 8的硫代和二硫代类似物，如权利要求1中所定义，其对映异构体，非对映体及其盐，特别是 其生理上可接受的酸加成盐，其具有有价值的性质，特别是对胆固醇生物合成的抑制作用，含有这些化合物的药物组合物，其用途和制备方法。
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