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1.发明申请Pharmaceutical Compositions Containing Hyaluronic Acid and Collagenase for the Topical Treatment of Wounds, Burns and Ulcers 有权含有透明质酸和胶原酶的药物组合物用于伤口，烧伤和溃疡的局部治疗公开(公告)号：US20080206228A1
公开(公告)日：2008-08-28
申请号：US11921835
申请日：2006-07-05
申请人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
发明人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
CPC分类号： A61K38/4886 , A61K9/0019 , A61K31/728 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/44 , A61K2300/00 , C12Y304/24003
摘要： The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
摘要翻译： 本发明涉及含有透明质酸或其衍生物与蛋白水解酶胶原酶（和相关药物制剂）相结合的新组合物，用于制备用于各种伤口局部治疗的敷料，不同深度的烧伤，压疮，血管 溃疡和糖尿病足溃疡以及为肥厚性瘢痕和瘢痕疙瘩的治疗。
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公开(公告)号：US20120219554A2
公开(公告)日：2012-08-30
申请号：US13318476
申请日：2009-05-14
IPC分类号： A61K38/47 , A61P43/00 , C12N9/24 , A61P35/00 , A61P37/08 , A61P7/04 , A61K39/395 , A61P29/00
CPC分类号： C12N9/2474 , A61K38/00 , A61K38/47 , A61K39/35 , A61K45/06 , C07K14/315 , C07K14/43595 , C12N9/2408 , C12Y302/01035
摘要： The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.
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公开(公告)号：US20120070441A1
公开(公告)日：2012-03-22
申请号：US13318476
申请日：2010-05-12
IPC分类号： A61K38/47 , A61P43/00 , C12N9/24 , A61P35/00 , A61P37/08 , A61P7/04 , A61K39/395 , A61P29/00
CPC分类号： C12N9/2474 , A61K38/00 , A61K38/47 , A61K39/35 , A61K45/06 , C07K14/315 , C07K14/43595 , C12N9/2408 , C12Y302/01035
摘要： The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.
摘要翻译： 本发明涉及分子量为21.6kDalton的koganeiensis链霉菌ATCC 31394透明质酸酶，其透明质酸酶活性和稳定性明显高于迄今为止从该微生物获得的透明质酸酶的稳定性。 本发明还涉及用于分离和纯化所述透明质酸酶的方法及其用于制备药物组合物或作为分析试剂的用途。
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4.发明授权Pharmaceutical compositions containing hyaluronic acid and collagenase for the topical treatment of wounds, burns and ulcers 有权含有透明质酸和胶原酶用于局部治疗伤口，烧伤和溃疡的药物组合物公开(公告)号：US08900576B2
公开(公告)日：2014-12-02
申请号：US11921835
申请日：2006-07-05
申请人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
发明人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
CPC分类号： A61K38/4886 , A61K9/0019 , A61K31/728 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/44 , A61K2300/00 , C12Y304/24003
摘要： The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
摘要翻译： 本发明涉及含有透明质酸或其衍生物与蛋白水解酶胶原酶（和相关药物制剂）相结合的新组合物，用于制备用于各种伤口局部治疗的敷料，不同深度的烧伤，压疮，血管 溃疡和糖尿病足溃疡以及治疗肥厚性和瘢痕疙瘩。
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