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1.发明申请Pharmaceutical Compositions Containing Hyaluronic Acid and Collagenase for the Topical Treatment of Wounds, Burns and Ulcers 有权含有透明质酸和胶原酶的药物组合物用于伤口，烧伤和溃疡的局部治疗公开(公告)号：US20080206228A1
公开(公告)日：2008-08-28
申请号：US11921835
申请日：2006-07-05
申请人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
发明人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
CPC分类号： A61K38/4886 , A61K9/0019 , A61K31/728 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/44 , A61K2300/00 , C12Y304/24003
摘要： The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
摘要翻译： 本发明涉及含有透明质酸或其衍生物与蛋白水解酶胶原酶（和相关药物制剂）相结合的新组合物，用于制备用于各种伤口局部治疗的敷料，不同深度的烧伤，压疮，血管 溃疡和糖尿病足溃疡以及为肥厚性瘢痕和瘢痕疙瘩的治疗。
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2.发明授权Pharmaceutical compositions containing hyaluronic acid and collagenase for the topical treatment of wounds, burns and ulcers 有权含有透明质酸和胶原酶用于局部治疗伤口，烧伤和溃疡的药物组合物公开(公告)号：US08900576B2
公开(公告)日：2014-12-02
申请号：US11921835
申请日：2006-07-05
申请人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
发明人： Susanna Vaccaro , Giovanni Gennari , Lanfranco Callegaro , Antonio Giannelli , Salvatore Caruso
CPC分类号： A61K38/4886 , A61K9/0019 , A61K31/728 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/44 , A61K2300/00 , C12Y304/24003
摘要： The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.
摘要翻译： 本发明涉及含有透明质酸或其衍生物与蛋白水解酶胶原酶（和相关药物制剂）相结合的新组合物，用于制备用于各种伤口局部治疗的敷料，不同深度的烧伤，压疮，血管 溃疡和糖尿病足溃疡以及治疗肥厚性和瘢痕疙瘩。
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公开(公告)号：US20120070441A1
公开(公告)日：2012-03-22
申请号：US13318476
申请日：2010-05-12
IPC分类号： A61K38/47 , A61P43/00 , C12N9/24 , A61P35/00 , A61P37/08 , A61P7/04 , A61K39/395 , A61P29/00
CPC分类号： C12N9/2474 , A61K38/00 , A61K38/47 , A61K39/35 , A61K45/06 , C07K14/315 , C07K14/43595 , C12N9/2408 , C12Y302/01035
摘要： The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.
摘要翻译： 本发明涉及分子量为21.6kDalton的koganeiensis链霉菌ATCC 31394透明质酸酶，其透明质酸酶活性和稳定性明显高于迄今为止从该微生物获得的透明质酸酶的稳定性。 本发明还涉及用于分离和纯化所述透明质酸酶的方法及其用于制备药物组合物或作为分析试剂的用途。
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公开(公告)号：US20130230594A1
公开(公告)日：2013-09-05
申请号：US13988285
申请日：2011-11-04
申请人： Giovanni Gennari , Giampaolo Menon , Susi Panfilo
发明人： Giovanni Gennari , Giampaolo Menon , Susi Panfilo
IPC分类号： A61K31/728 , A61K33/38
CPC分类号： A61K31/728 , A61K9/0014 , A61K33/38 , A61K47/36 , A61K2300/00
摘要： The present invention relates to compositions based on silver and hyaluronic acid and their use in the management of cutaneous lesions of various origin (acute and chronic wounds, ulcerations, burns, etc.) mainly when characterized by the presence of exudate and hence at high risk of infection.
摘要翻译： 本发明涉及基于银和透明质酸的组合物及其用于管理各种来源的皮肤损伤（急性和慢性伤口，溃疡，烧伤等），主要在以渗出物存在为特征并因此处于高风险 的感染。
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公开(公告)号：US20100249156A1
公开(公告)日：2010-09-30
申请号：US12676311
申请日：2008-09-03
IPC分类号： A61K31/522 , A61P31/22
CPC分类号： A61K9/0034 , A61K9/06 , A61K31/522 , A61K47/32 , A61K47/36
摘要： The invention relates to topical formulations in the form of a bioadhesive hydrophilic gel comprising acyclovir as active ingredient, Sodium hyaluronate and an acrylic polymer. Said formulations improve the local administration of acyclovir in the treatment of herpes infections, because they possess good properties of adherence to the mucosa and high resistance to physiological removal mechanisms.
摘要翻译： 本发明涉及包含阿昔洛韦作为活性成分，透明质酸钠和丙烯酸聚合物的生物粘附亲水凝胶形式的局部制剂。 所述制剂改善了阿昔洛韦在治疗疱疹感染中的局部施用，因为它们具有粘附于粘膜的良好性质和对生理去除机制的高抗性。
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6.发明申请Microemulsions of retinoids, and pharmaceutical compositions containing them 有权类维生素A的微乳液和含有它们的药物组合物公开(公告)号：US20070134276A1
公开(公告)日：2007-06-14
申请号：US10575616
申请日：2004-10-08
IPC分类号： A61K9/00 , A61K31/203 , A61K31/728
CPC分类号： A61K9/0014 , A61K9/1075 , A61K31/07 , A61K31/167 , A61K47/24 , A61K47/26
摘要： Disclosed are water-in-oil (W/O) microemulsions containing as active ingredient a retinoid, a phospholipid emulsifier, and possibly hyaluronic acid or salts thereof.
摘要翻译： 公开了含有类视黄醇，磷脂乳化剂和可能的透明质酸或其盐作为活性成分的油包水（W / O）微乳液。
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7.发明授权Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity 有权基于硫酸化透明质酸作为细胞因子活性的活化或抑制剂的主题使用药物公开(公告)号：US09504708B2
公开(公告)日：2016-11-29
申请号：US13320000
申请日：2010-05-14
申请人： Matteo D'Este , Giovanni Gennari
发明人： Matteo D'Este , Giovanni Gennari
IPC分类号： A61K31/737 , A61K45/06 , A61K31/136
摘要： The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.
摘要翻译： 本发明的目的涉及硫酸化透明质酸（HAS）作为细胞因子活性（促炎和消炎）的调节剂的新颖且令人惊奇的用途，因此使用HAS来制备用于主题的新药 用于预防和治疗与促炎和抗炎性质的细胞因子的活化和/或缺乏相关的病理学。 申请人实际上已经发现HAS在调节这些特定蛋白质的活性方面的排他能力，已经研究了作用机制，并证明了现有技术中已知的不同硫酸化类型之间的显着差异，但首先它已经证实 HAS对疱疹病毒，巨细胞病毒和水泡性口炎病毒的不同类型和毒株的意想不到的高活性。 最后，本发明的另一个目的是使用HAS作为抗炎性质的药物的皮肤吸收促进剂。
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公开(公告)号：US09265793B2
公开(公告)日：2016-02-23
申请号：US13988285
申请日：2011-11-04
申请人： Giovanni Gennari , Giampaolo Menon , Susi Panfilo
发明人： Giovanni Gennari , Giampaolo Menon , Susi Panfilo
IPC分类号： A61K31/728 , A61K33/38 , A61K9/00 , A61K47/36
CPC分类号： A61K31/728 , A61K9/0014 , A61K33/38 , A61K47/36 , A61K2300/00
摘要： The present invention relates to compositions based on silver and hyaluronic acid and their use in the management of cutaneous lesions of various origin (acute and chronic wounds, ulcerations, burns, etc.) mainly when characterized by the presence of exudate and hence at high risk of infection.
摘要翻译： 本发明涉及基于银和透明质酸的组合物及其用于管理各种来源的皮肤损伤（急性和慢性伤口，溃疡，烧伤等），主要在以渗出物存在为特征并因此处于高风险 的感染。
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公开(公告)号：US08633169B2
公开(公告)日：2014-01-21
申请号：US12676311
申请日：2008-09-03
IPC分类号： A61K31/715
CPC分类号： A61K9/0034 , A61K9/06 , A61K31/522 , A61K47/32 , A61K47/36
摘要： The invention relates to topical formulations in the form of a bioadhesive hydrophilic gel comprising acyclovir as active ingredient, Sodium hyaluronate and an acrylic polymer. Said formulations improve the local administration of acyclovir in the treatment of herpes infections, because they possess good properties of adherence to the mucosa and high resistance to physiological removal mechanisms.
摘要翻译： 本发明涉及包含阿昔洛韦作为活性成分，透明质酸钠和丙烯酸聚合物的生物粘附亲水凝胶形式的局部制剂。 所述制剂改善了阿昔洛韦在治疗疱疹感染中的局部施用，因为它们具有粘附于粘膜的良好性质和对生理去除机制的高抗性。
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10.发明授权Microemulsions of retinoids, and pharmaceutical compositions containing them 有权类维生素A的微乳液和含有它们的药物组合物公开(公告)号：US07781489B2
公开(公告)日：2010-08-24
申请号：US10575616
申请日：2004-10-08
CPC分类号： A61K9/0014 , A61K9/1075 , A61K31/07 , A61K31/167 , A61K47/24 , A61K47/26
摘要： Disclosed are water-in-oil (W/O) microemulsions containing as active ingredient a retinoid, a phospholipid emulsifier, and possibly hyaluronic acid or salts thereof.
摘要翻译： 公开了含有类视黄醇，磷脂乳化剂和可能的透明质酸或其盐作为活性成分的油包水（W / O）微乳液。
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