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公开(公告)号：US20120115743A1
公开(公告)日：2012-05-10
申请号：US13254571
申请日：2010-03-03
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C40B60/12
摘要： A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue.
摘要翻译： 提供了一种将甲状腺结节组织分类为恶性或良性的系统，其基于鉴定基因转录物的集合，其特征在于一组基因转录物内每个基因转录物的表达变化可以与恶性 或良性甲状腺结节病。 甲状腺分类系统提供“甲状腺分类”靶序列的集合，并进一步提供多核苷酸探针和从其衍生的引物的组合。 多核苷酸探针的这些组合可以以溶液或阵列形式提供。 探针和阵列的组合可用于诊断。 本发明还提供了进一步分类甲状腺结节组织的方法。
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2.发明申请公开(公告)号：US20120172243A1
公开(公告)日：2012-07-05
申请号：US13258429
申请日：2010-04-29
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue.
摘要翻译： 提供了一种将甲状腺结节组织分类为恶性或良性的系统，其基于鉴定基因转录物的集合，其特征在于一组基因转录物内的每个基因转录物的表达变化可以与恶性的 或良性甲状腺结节病。 甲状腺分类系统提供“甲状腺分类”靶序列的集合，并进一步提供多核苷酸探针和从其衍生的引物的组合。 这些多核苷酸探针的组合可以以溶液或阵列形式提供。 探针和阵列的组合可用于诊断。 本发明还提供了进一步分类甲状腺结节组织的方法。
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3.发明授权公开(公告)号：US09206482B2
公开(公告)日：2015-12-08
申请号：US13258429
申请日：2010-04-29
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue.
摘要翻译： 提供了一种将甲状腺结节组织分类为恶性或良性的系统，其基于鉴定基因转录物的集合，其特征在于一组基因转录物内的每个基因转录物的表达变化可以与恶性的 或良性甲状腺结节病。 甲状腺分类系统提供“甲状腺分类”靶序列的集合，并进一步提供多核苷酸探针和从其衍生的引物的组合。 这些多核苷酸探针的组合可以以溶液或阵列形式提供。 探针和阵列的组合可用于诊断。 本发明还提供了进一步分类甲状腺结节组织的方法。
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公开(公告)号：US09074258B2
公开(公告)日：2015-07-07
申请号：US13254571
申请日：2010-03-03
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C40B60/12
摘要： A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue.
摘要翻译： 提供了一种将甲状腺结节组织分类为恶性或良性的系统，其基于鉴定基因转录物的集合，其特征在于一组基因转录物内的每个基因转录物的表达变化可以与恶性的 或良性甲状腺结节病。 甲状腺分类系统提供“甲状腺分类”靶序列的集合，并进一步提供多核苷酸探针和从其衍生的引物的组合。 这些多核苷酸探针的组合可以以溶液或阵列形式提供。 探针和阵列的组合可用于诊断。 本发明还提供了进一步分类甲状腺结节组织的方法。
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