公开(公告)号：US07311727B2

公开(公告)日：2007-12-25

申请号：US10771647

申请日：2004-02-04

Applicant: Mark M. Mazumder ,  Jawahar L. Mehta ,  Malay K. Mazumder ,  Nawab Ali ,  Steven Trigwell ,  Rajesh Sharma ,  Samiran De

Inventor： Mark M. Mazumder ,  Jawahar L. Mehta ,  Malay K. Mazumder ,  Nawab Ali ,  Steven Trigwell ,  Rajesh Sharma ,  Samiran De

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2/90 ,  A61F2002/0086 ,  A61F2250/0067 ,  A61L31/005 ,  A61L31/10 ,  A61L2300/608 ,  A61L2420/08 ,  C08L75/04 ,  C08L71/02

Abstract: An encased stent that discourages restenosis by having a homogenous endothelial cell lining along the inner wall of the stent. The endothelial cell lining may be coated on the stent before the stent is placed in the artery, or the endothelial cell lining may be grown after placement by several factors that encourage such growth and discourage restenosis. The endothelial cells to coat the stent may be genetically modified to enhance the growth of the endothelial cells into a homogeneous lining. The stent has a continuous lining in the form of a multi-layer polymer coating, including a conducting biocorrosion inhibiting layer and a continuous film of polyurethane coupled by a coupling agent to polyethylene glycol. Various drugs and cell factors may be incorporated into the lining, such as anti-thrombin, anti-inflammatory and anti-coagulant drugs, cell cycle inhibitors, and vascular endothelial growth factors.

Abstract translation: 包裹的支架通过沿着支架的内壁衬里均匀的内皮细胞阻止再狭窄。 在将支架放置在动脉内之前，内皮细胞衬里可以涂覆在支架上，或者内皮细胞内衬可以通过鼓励这种生长并阻止再狭窄的若干因素放置后生长。 涂覆支架的内皮细胞可以被遗传修饰以增强内皮细胞生长成均匀的衬里。 支架具有多层聚合物涂层形式的连续衬里，其包括导电生物腐蚀抑制层和通过偶联剂与聚乙二醇偶联的连续聚氨酯膜。 各种药物和细胞因子可以并入衬里，例如抗凝血酶，抗炎和抗凝血药物，细胞周期抑制剂和血管内皮生长因子。