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公开(公告)号：US07060717B2
公开(公告)日：2006-06-13
申请号：US10865263
申请日：2004-06-09
申请人： Simon Bailey , Elisabeth C. L. Gautier , Alan J. Henderson , Thomas V. Magee , Anthony Marfat , John P. Mathias , Dale G. McLeod , Sandra M. Monaghan , Blanda L. C. Stammen
发明人： Simon Bailey , Elisabeth C. L. Gautier , Alan J. Henderson , Thomas V. Magee , Anthony Marfat , John P. Mathias , Dale G. McLeod , Sandra M. Monaghan , Blanda L. C. Stammen
IPC分类号： A61K31/445 , C07D211/72
CPC分类号： C07D213/82 , A61K31/4433 , A61K31/455 , A61K31/46 , A61K31/537 , A61K45/06 , C07D401/12 , C07D405/12 , C07D451/04 , C07D451/10 , Y02A50/411 , A61K2300/00
摘要： The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.
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公开(公告)号：US06949573B2
公开(公告)日：2005-09-27
申请号：US10361062
申请日：2003-02-06
申请人： Simon Bailey , Elisabeth C. L. Gautier , Alan J. Henderson , Thomas V. Magee , Anthony Marfat , John P. Mathias , Dale G. McLeod , Sandra M. Monaghan , Blanda L. C. Stammen
发明人： Simon Bailey , Elisabeth C. L. Gautier , Alan J. Henderson , Thomas V. Magee , Anthony Marfat , John P. Mathias , Dale G. McLeod , Sandra M. Monaghan , Blanda L. C. Stammen
IPC分类号： A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4545 , A61K31/455 , A61K31/46 , A61K31/537 , A61K45/06 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/06 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/02 , A61P29/00 , A61P31/16 , A61P31/22 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07D213/82 , C07D401/12 , C07D405/12 , C07D451/04 , C07D451/10 , C07D213/643
CPC分类号： C07D213/82 , A61K31/4433 , A61K31/455 , A61K31/46 , A61K31/537 , A61K45/06 , C07D401/12 , C07D405/12 , C07D451/04 , C07D451/10 , Y02A50/411 , A61K2300/00
摘要： The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.
摘要翻译： 本发明涉及烟酰胺衍生物以及制备用于制备含有这些衍生物的组合物和用途的中间体的方法。 根据本发明的烟酰胺衍生物可用于许多疾病，病症和病症，特别是炎性，过敏性，呼吸道疾病，病症和病症以及伤口。
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公开(公告)号：US06900309B1
公开(公告)日：2005-05-31
申请号：US09590585
申请日：2000-06-08
IPC分类号： C07H19/167 , A61K31/7076 , A61P1/00 , A61P1/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P25/00 , A61P25/08 , A61P27/16 , A61P29/00 , A61P31/04 , A61P37/08 , A61P43/00 , C07H19/16 , A61K31/70 , C07H19/173
CPC分类号： C07H19/16
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds as adenosine A2a receptor agonists.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐和溶剂化物，以及制备用于制备含有腺苷A2a受体激动剂的化合物和组合物的用途的方法。
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公开(公告)号：US06326359B1
公开(公告)日：2001-12-04
申请号：US09419482
申请日：1999-10-15
IPC分类号： A61K3170
CPC分类号： C07H19/16
摘要： The present invention provides compounds of formula (I): and pharmaceutically acceptable salts and solvates thereof, together with processes for the preparation of, compositions containing, uses of and intermediates used in the preparation of such compounds that have A2a receptor agonist activity.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐和溶剂合物，以及制备含有用途的组合物，用于制备具有A2a受体激动剂活性的化合物的中间体的方法。
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