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    Inhibition of Tumor Angiogenesis by Inhibition of Peroxiredoxin 1 (PRX1)
    3.
    发明申请
    Inhibition of Tumor Angiogenesis by Inhibition of Peroxiredoxin 1 (PRX1) 审中-公开
    抑制过氧化还原酶1（PRX1）抑制肿瘤血管生成

    公开(公告)号：US20110177091A1

    公开(公告)日：2011-07-21

    申请号：US12963039

    申请日：2010-12-08

    申请人： Sandra O. Gollnick ,  Jonah Riddell

    发明人： Sandra O. Gollnick ,  Jonah Riddell

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： A61K38/44 ,  C07K16/40 ,  C07K2317/76 ,  C07K2317/77 ,  C12Y111/01015

    摘要： Provided is a method for inhibiting angiogenesis in a tumor. The method involves administering to an individual who has a tumor a composition that contains an agent capable of inhibiting binding of peroxiredoxin 1 (Prx1) to Toll like receptor 4 (TLR4) such that angiogenesis in the tumor is inhibited subsequent to the administration. The agent that is capable of inhibiting binding of Prx1 to TLR4 can be an antibody to Prx1, a Prx1 binding fragment of the antibody, or a peptide. The peptide can be capable of inhibiting the formation of a Prx1 decamer, or can inhibit binding of Prx1 to TLR4 by steric interference, or by competitions with Prx1 for TLR4 binding. The tumor in which angiognesis is inhibited can be any type of cancer tumor.

    摘要翻译： 提供抑制肿瘤中血管生成的方法。 该方法涉及对具有肿瘤的个体施用含有能够抑制过氧化还原酶1（Prx1）与Toll样受体4（TLR4）结合的试剂的组合物，使得在施用后肿瘤中的血管生成被抑制。 能够抑制Prx1与TLR4结合的药剂可以是Prx1抗体，抗体的Prx1结合片段或肽。 该肽能够抑制Prx1十聚体的形成，或者可通过立体干扰抑制Prx1与TLR4的结合，或者通过Prx1与TLR4结合的竞争来抑制。 其中血管发生被抑制的肿瘤可以是任何类型的癌肿瘤。