公开(公告)号：US5505956A

公开(公告)日：1996-04-09

申请号：US186925

申请日：1994-04-01

申请人： Jung J. Kim ,  Woo Y. Lee ,  Jong W. Ahn ,  Sang H. Han

发明人： Jung J. Kim ,  Woo Y. Lee ,  Jong W. Ahn ,  Sang H. Han

IPC分类号： A61K9/70 ,  A61F13/00

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7076 ,  A61K9/7092

摘要： Disclosed herein is a medicinal adhesive for percutaneous administration of a drug consisting of a support (backing layer), an adhesive layer comprising an oil-soluble drug, an adhesive resin, a penetration enhancer, a water-absorptive material and a lenitive agent, and a separate liner, charaterized in that the adhesive layer has a laminated structure having 2 to 5 layers and each layer has different water absorption capacities, and the drug is a oil-soluble, non-steroidal drug. For the adhesive of the present invention, the lowest layer which is to be contacted with the skin has the lowest water absorption capacity and the most upper layer in contact with the support has the highest water absorption capacity, or vice versa.

摘要翻译： 本文公开了一种用于经皮施用药物的药用粘合剂，其由支撑体（背衬层），包含油溶性药物的粘合剂层，粘合剂树脂，渗透增强剂，吸水材料和膨胀剂组成，以及 单独的衬垫，其特征在于粘合剂层具有2至5层的层压结构，每层具有不同的吸水能力，并且药物是油溶性非甾体药物。 对于本发明的粘合剂，与皮肤接触的最低层具有最低的吸水能力，与载体接触的最上层具有最高的吸水能力，反之亦然。