公开(公告)号：US07781169B1

公开(公告)日：2010-08-24

申请号：US10019067

申请日：2000-06-28

申请人： Mats Paulsson ,  Uwe Odenthal ,  Neil Smyth ,  Daniel Aeschlimann ,  Sarolta Karpati ,  Miklos Sardy

发明人： Mats Paulsson ,  Uwe Odenthal ,  Neil Smyth ,  Daniel Aeschlimann ,  Sarolta Karpati ,  Miklos Sardy

IPC分类号： G01N33/53

CPC分类号： G01N33/564 ,  G01N2333/9108 ,  G01N2800/202 ,  G01N2800/24 ,  Y10S436/811

摘要： Method for diagnosis of autoimmune diseases of the GSE-type or associated with gluten sensitive enteropathy comprising taking a sample and testing the sample for antibodies against human tissue transglutaminase, tissue-specific transglutaminases, or other transglutaminases. It was found that autoimmune diseases other than celiac disease can be diagnosed and distinguished in this way, notably, dermatitis herpetiformis Duhring, Crohn's disease, Addison's disease, AI hemolytic anemia, AI thrombocytopenic purpura, AI thyroid diseases, atrophic gastritis—pernicious anemia, IgA nephropathy or IgA glomerulonephritis, myasthenia gravis, partial lipodystrophy, polymyositis, primary biliary cirrhosis, primary sclerosing cholangitis, recurrent pericarditis, relapsing polychondritis, rheumatoid arthritis, rheumatism, sarcoidosis, Sjögren's syndrome, SLE, splenic atrophy, type I (insulin-dependent) diabetes mellitus, diabetes mellitus of other types, ulcerative colitis, vasculitis (both systemic and cutaneous), vitiligo as well as autoimmune diseases associated with infertility, increased risk of abortion, or reduced fetal growth.

摘要翻译： 用于诊断GSE型自身免疫性疾病或与麸质敏感性肠病相关的方法，包括取样并测试样品以获得针对人组织转谷氨酰胺酶，组织特异性转谷氨酰胺酶或其他转谷氨酰胺酶的抗体。 发现腹腔疾病以外的自身免疫性疾病可以以这种方式进行诊断和鉴别，特别是疱疹性疱疹性杜氏病，克罗恩病，艾迪生病，溶血性贫血，AI血小板减少性紫癜，AI甲状腺疾病，萎缩性胃炎恶性贫血，IgA 肾病或IgA肾小球肾炎，重症肌无力，部分脂肪营养不良，多发性肌炎，原发性胆汁性肝硬化，原发性硬化性胆管炎，复发性心包炎，复发性多软骨炎，类风湿性关节炎，风湿病，结节病，Sjögren综合征，SLE，脾萎缩，I型（胰岛素依赖型） 其他类型的糖尿病，溃疡性结肠炎，全身和皮肤的血管炎，白癜风以及与不孕不育相关的自身免疫性疾病，流产风险增加或胎儿生长减少。