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公开(公告)号：US07781169B1
公开(公告)日：2010-08-24
申请号：US10019067
申请日：2000-06-28
申请人： Mats Paulsson , Uwe Odenthal , Neil Smyth , Daniel Aeschlimann , Sarolta Karpati , Miklos Sardy
发明人： Mats Paulsson , Uwe Odenthal , Neil Smyth , Daniel Aeschlimann , Sarolta Karpati , Miklos Sardy
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2333/9108 , G01N2800/202 , G01N2800/24 , Y10S436/811
摘要： Method for diagnosis of autoimmune diseases of the GSE-type or associated with gluten sensitive enteropathy comprising taking a sample and testing the sample for antibodies against human tissue transglutaminase, tissue-specific transglutaminases, or other transglutaminases. It was found that autoimmune diseases other than celiac disease can be diagnosed and distinguished in this way, notably, dermatitis herpetiformis Duhring, Crohn's disease, Addison's disease, AI hemolytic anemia, AI thrombocytopenic purpura, AI thyroid diseases, atrophic gastritis—pernicious anemia, IgA nephropathy or IgA glomerulonephritis, myasthenia gravis, partial lipodystrophy, polymyositis, primary biliary cirrhosis, primary sclerosing cholangitis, recurrent pericarditis, relapsing polychondritis, rheumatoid arthritis, rheumatism, sarcoidosis, Sjögren's syndrome, SLE, splenic atrophy, type I (insulin-dependent) diabetes mellitus, diabetes mellitus of other types, ulcerative colitis, vasculitis (both systemic and cutaneous), vitiligo as well as autoimmune diseases associated with infertility, increased risk of abortion, or reduced fetal growth.
摘要翻译： 用于诊断GSE型自身免疫性疾病或与麸质敏感性肠病相关的方法，包括取样并测试样品以获得针对人组织转谷氨酰胺酶，组织特异性转谷氨酰胺酶或其他转谷氨酰胺酶的抗体。 发现腹腔疾病以外的自身免疫性疾病可以以这种方式进行诊断和鉴别，特别是疱疹性疱疹性杜氏病，克罗恩病，艾迪生病，溶血性贫血，AI血小板减少性紫癜，AI甲状腺疾病，萎缩性胃炎恶性贫血，IgA 肾病或IgA肾小球肾炎，重症肌无力，部分脂肪营养不良，多发性肌炎，原发性胆汁性肝硬化，原发性硬化性胆管炎，复发性心包炎，复发性多软骨炎，类风湿性关节炎，风湿病，结节病，Sjögren综合征，SLE，脾萎缩，I型（胰岛素依赖型） 其他类型的糖尿病，溃疡性结肠炎，全身和皮肤的血管炎，白癜风以及与不孕不育相关的自身免疫性疾病，流产风险增加或胎儿生长减少。
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公开(公告)号：US5736132A
公开(公告)日：1998-04-07
申请号：US592921
申请日：1996-01-29
CPC分类号： C12N9/1044 , A61K38/45 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/102 , A61L2300/254 , A61L2300/414 , Y10S514/953 , Y10S514/955 , Y10S514/965 , Y10S530/835 , Y10S530/84 , Y10S530/841 , Y10S530/842 , Y10S530/846 , Y10S530/85
摘要： A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
摘要翻译： 配制的生物粘合剂组合物在药学上可接受的水性载体中使用组织转谷氨酰胺酶。 组织转谷氨酰胺酶以有效的催化量使用，以通过催化组织和/或酶的谷氨酰胺残基和胺供体之间的反应来促进组织表面之间的粘附。 载体包含二价金属离子如钙，以促进所述反应。
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3.发明授权Biological adhesive composition and method of promoting adhesion between tissue surfaces 失效生物粘合剂组合物和促进组织表面之间粘附的方法
公开(公告)号：US5549904A
公开(公告)日：1996-08-27
申请号：US071528
申请日：1993-06-03
CPC分类号： C12N9/1044 , A61K38/45 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/102 , A61L2300/254 , A61L2300/414 , Y10S514/953 , Y10S514/955 , Y10S514/965 , Y10S530/835 , Y10S530/84 , Y10S530/841 , Y10S530/842 , Y10S530/846 , Y10S530/85
摘要： A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
摘要翻译： 配制的生物粘合剂组合物在药学上可接受的水性载体中使用组织转谷氨酰胺酶。 组织转谷氨酰胺酶以有效的催化量使用，以通过催化组织和/或酶的谷氨酰胺残基和胺供体之间的反应来促进组织表面之间的粘附。 载体包含二价金属离子如钙，以促进所述反应。
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公开(公告)号：US20130196336A1
公开(公告)日：2013-08-01
申请号：US12594926
申请日：2008-04-07
CPC分类号： G01N33/6896 , C12N9/1044 , G01N33/573 , G01N33/6854 , G01N33/86 , G01N2333/9108 , G01N2800/065 , G01N2800/24 , G01N2800/28
摘要： The embodiments relate to the diagnosis of disorders or dysfunctions characterised by autoimmune responses to a novel antigen, transglutaminase 6, by the detection of autoantibodies to the novel antigen.
摘要翻译： 实施方案涉及通过检测对新抗原的自身抗体来诊断特征在于对新型抗原，转谷氨酰胺酶6的自身免疫应答的病症或功能障碍。
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5.发明申请Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same 审中-公开透明质酸的官能化衍生物，使用它们原位形成水凝胶，以及制备和使用它们的方法公开(公告)号：US20070149441A1
公开(公告)日：2007-06-28
申请号：US11706922
申请日：2007-02-13
申请人： Daniel Aeschlimann , Paul Bulpitt
发明人： Daniel Aeschlimann , Paul Bulpitt
IPC分类号： A61K38/14 , A61K31/728 , C08B37/00 , C07K9/00
CPC分类号： C12N5/0068 , A61K9/0024 , A61K31/728 , A61K47/36 , A61L24/08 , A61L27/20 , C08B37/0072 , C08L5/08 , C12N2533/80
摘要： Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.
摘要翻译： 提供透明质酸的化学修饰方法，胺或醛官能化透明质酸的形成及其交联以形成水凝胶。 本发明的功能化透明质酸水凝胶可以原位聚合，可生物降解，并可用作组织粘合剂，组织分离器，药物递送系统，细胞培养基质和用于组织再生的临时支架。
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公开(公告)号：US07196180B2
公开(公告)日：2007-03-27
申请号：US10680000
申请日：2003-10-06
申请人： Daniel Aeschlimann , Paul Bulpitt
发明人： Daniel Aeschlimann , Paul Bulpitt
IPC分类号： A61K31/728 , A61K31/738
CPC分类号： C12N5/0068 , A61K9/0024 , A61K31/728 , A61K47/36 , A61L24/08 , A61L27/20 , C08B37/0072 , C08L5/08 , C12N2533/80
摘要： Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.
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7.发明授权Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same 失效透明质酸的官能化衍生物，使用它们原位形成水凝胶，以及制备和使用它们的方法公开(公告)号：US06630457B1
公开(公告)日：2003-10-07
申请号：US09156829
申请日：1998-09-18
申请人： Daniel Aeschlimann , Paul Bulpitt
发明人： Daniel Aeschlimann , Paul Bulpitt
IPC分类号： A61K3800
CPC分类号： C12N5/0068 , A61K9/0024 , A61K31/728 , A61K47/36 , A61L24/08 , A61L27/20 , C08B37/0072 , C08L5/08 , C12N2533/80
摘要： Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, are biodegradable, and can serve as a tissue adhesive, a tissue separator, a drug delivery system, a matrix for cell cultures, and a temporary scaffold for tissue regeneration.
摘要翻译： 提供透明质酸的化学修饰方法，胺或醛官能化透明质酸的形成及其交联以形成水凝胶。 本发明的功能化透明质酸水凝胶可以原位聚合，可生物降解，并可用作组织粘合剂，组织分离器，药物递送系统，细胞培养基质和用于组织再生的临时支架。
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