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1.发明申请Anticancer Agent Containing Dendritic Cell Having Rna Virus Transferred Thereinto 有权含有转移Rna病毒的树突状细胞的抗癌剂公开(公告)号：US20080014183A1
公开(公告)日：2008-01-17
申请号：US11630532
申请日：2005-04-28
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
IPC分类号： A61K48/00
CPC分类号： A61K35/76 , A61K35/768 , A61K38/179 , A61K38/215 , A61K2039/5154 , C12N2760/18832 , C12N2760/18871
摘要： The present invention provides anticancer agents comprising dendritic cells introduced with RNA viruses. The present invention also provides methods for producing anticancer agents, which comprise the step of preparing dendritic cells introduced with RNA viruses. The present invention also provides methods for treating cancers using dendritic cells introduced with RNA viruses. The present invention provides effective methods for treating cancers, which use RNA viruses and dendritic cells in combination
摘要翻译： 本发明提供包含引入RNA病毒的树突状细胞的抗癌剂。 本发明还提供了制备抗癌剂的方法，其包括制备引入RNA病毒的树突状细胞的步骤。 本发明还提供了用RNA病毒引入的树突状细胞治疗癌症的方法。 本发明提供了组合使用RNA病毒和树突状细胞的治疗癌症的有效方法
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2.发明授权Anticancer agent containing dendritic cell having RNA virus transferred thereinto 有权含有转录有RNA病毒的树突状细胞的抗癌剂公开(公告)号：US08889118B2
公开(公告)日：2014-11-18
申请号：US11630532
申请日：2005-04-28
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
CPC分类号： A61K35/76 , A61K35/768 , A61K38/179 , A61K38/215 , A61K2039/5154 , C12N2760/18832 , C12N2760/18871
摘要： The present invention provides anticancer agents comprising dendritic cells introduced with RNA viruses. The present invention also provides methods for producing anticancer agents, which comprise the step of preparing dendritic cells introduced with RNA viruses. The present invention also provides methods for treating cancers using dendritic cells introduced with RNA viruses. The present invention provides effective methods for treating cancers, which use RNA viruses and dendritic cells in combination.
摘要翻译： 本发明提供包含引入RNA病毒的树突状细胞的抗癌剂。 本发明还提供了制备抗癌剂的方法，其包括制备引入RNA病毒的树突状细胞的步骤。 本发明还提供了用RNA病毒引入的树突状细胞治疗癌症的方法。 本发明提供了组合使用RNA病毒和树突状细胞的治疗癌症的有效方法。
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公开(公告)号：US20080031855A1
公开(公告)日：2008-02-07
申请号：US11630522
申请日：2005-04-28
申请人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
发明人： Shinji Okano , Yoshikazu Yonemitsu , Katsuo Sueishi , Satoko Shibata , Mamoru Hasegawa , Haruhiko Kondo
CPC分类号： A61K35/76 , A61K35/768 , A61K38/179 , A61K38/215 , A61K2039/5154 , C12N2760/18832 , C12N2760/18871
摘要： Minus-strand RNA viruses were found to have an effective tumor-suppressive effect even when they did not carry a therapeutically effective gene. The present invention provides anticancer agents comprising a minus-strand RNA virus. Furthermore, the present invention provides methods for producing the anticancer agents, which comprise the step of mixing a minus-strand RNA virus with pharmaceutically acceptable carriers. Furthermore, the present invention provides methods for suppressing cancer, which comprise the step of administering a minus-strand RNA virus to cancer tissues.
摘要翻译： 发现减数RNA病毒即使不携带治疗有效的基因也具有有效的肿瘤抑制作用。 本发明提供了包含负链RNA病毒的抗癌剂。 此外，本发明提供了制造抗癌剂的方法，其包括将负链RNA病毒与药学上可接受的载体混合的步骤。 此外，本发明提供了抑制癌症的方法，其包括向癌组织施用负链RNA病毒的步骤。
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公开(公告)号：US20070269414A1
公开(公告)日：2007-11-22
申请号：US10578085
申请日：2004-10-29
CPC分类号： C12N15/86 , A61K2039/5156 , C12N2510/02 , C12N2760/18843
摘要： The present invention provides a method for introducing a gene into a dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention also provides a method for producing a gene transferred dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention also provides gene transferred dendritic cells produced by such methods. Furthermore, the present invention provides a method for activating a dendritic cell, which includes the step of contacting a minus-strand RNA virus with a dendritic cell. The present invention enables efficient gene delivery into dendritic cells. Dendritic cells introduced with antigen gene or cytokine gene are useful as vaccine.
摘要翻译： 本发明提供了将基因导入树状细胞的方法，其包括使负链RNA病毒与树突状细胞接触的步骤。 本发明还提供了一种转基因树突状细胞的制备方法，其包括将负链RNA病毒与树突状细胞接触的步骤。 本发明还提供了通过这些方法产生的基因转移的树突状细胞。 此外，本发明提供了激活树突细胞的方法，其包括使负链RNA病毒与树突状细胞接触的步骤。 本发明使得有效的基因递送到树突状细胞中。 引入抗原基因或细胞因子基因的树突状细胞可用作疫苗。
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