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公开(公告)号：US20100261198A1
公开(公告)日：2010-10-14
申请号：US12681232
申请日：2008-10-03
申请人： Kenneth G. Mann , Saulius Butenas , Anetta Undas
发明人： Kenneth G. Mann , Saulius Butenas , Anetta Undas
IPC分类号： G01N33/573 , G01N33/53
CPC分类号： C12Q1/56 , G01N33/86 , G01N2800/2871 , G01N2800/323 , G01N2800/324 , G01N2800/325
摘要： The invention provides compositions and methods for the detection of Factor XIa or Tissue Factor (TF) activity in a sample using an antibody based clotting time prolongation assay. The invention provides methods for detection of FXIa or TF activity in a sample using a fluorogenic substrate. Further provided herein is a correlation between elevated levels of FXIa and/or TF with inflammation, acute coronary syndrome (ACS), myocardial infarction, coronary artery disease (CAD), heart failure, aortic stenosis, stroke, or transient ischemic attack. The frequency of FXIa and TF activity was substantially lower in individuals with stable coronary artery disease and no history of myocardial infarction. No FXIa or TF activity was observed in healthy individuals.
摘要翻译： 本发明提供了使用基于抗体的凝血时间延长测定法在样品中检测因子XIa或组织因子（TF）活性的组合物和方法。 本发明提供了使用荧光底物检测样品中FXIa或TF活性的方法。 本文进一步提供的是FXIa和/或TF与炎症，急性冠状动脉综合征（ACS），心肌梗塞，冠状动脉疾病（CAD），心力衰竭，主动脉瓣狭窄，中风或短暂性脑缺血发作的升高水平之间的相关性。 FXIa和TF活动的频率在冠状动脉疾病稳定且无心肌梗死史的个体中显着降低。 健康人中没有观察到FXIa或TF活性。
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公开(公告)号：US08574849B2
公开(公告)日：2013-11-05
申请号：US12681232
申请日：2008-10-03
申请人： Kenneth G. Mann , Saulius Butenas , Anetta Undas
发明人： Kenneth G. Mann , Saulius Butenas , Anetta Undas
IPC分类号： G01N33/53
CPC分类号： C12Q1/56 , G01N33/86 , G01N2800/2871 , G01N2800/323 , G01N2800/324 , G01N2800/325
摘要： The invention provides compositions and methods for the detection of Factor XIa or Tissue Factor (TF) activity in a sample using an antibody based clotting time prolongation assay. The invention provides methods for detection of FXIa or TF activity in a sample using a fluorogenic substrate. Further provided herein is a correlation between elevated levels of FXIa and/or TF with inflammation, acute coronary syndrome (ACS), myocardial infarction, coronary artery disease (CAD), heart failure, aortic stenosis, stroke, or transient ischemic attack. The frequency of FXIa and TF activity was substantially lower in individuals with stable coronary artery disease and no history of myocardial infarction. No FXIa or TF activity was observed in healthy individuals.
摘要翻译： 本发明提供了使用基于抗体的凝血时间延长测定法在样品中检测因子XIa或组织因子（TF）活性的组合物和方法。 本发明提供了使用荧光底物检测样品中FXIa或TF活性的方法。 本文进一步提供的是FXIa和/或TF与炎症，急性冠状动脉综合征（ACS），心肌梗塞，冠状动脉疾病（CAD），心力衰竭，主动脉瓣狭窄，中风或短暂性脑缺血发作的升高水平之间的相关性。 FXIa和TF活动的频率在冠状动脉疾病稳定且无心肌梗死史的个体中显着降低。 健康人中没有观察到FXIa或TF活性。
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公开(公告)号：US07015193B2
公开(公告)日：2006-03-21
申请号：US10125950
申请日：2002-04-19
CPC分类号： A61K38/4846 , A61K9/127 , C07K14/755 , Y10S514/802 , Y10S514/834
摘要： Disclosed are compositions for treating blood coagulation disorders and allows for manipulation of the blood coagulation cascade. More particularly the invention, relates to compositions for altering bleeding that include a mixture of at least one blood coagulation factor in a low dose and phospholipid vesicles. The invention has a variety of important uses including controlling bleeding in a mammal that has or is suspected of having a potentially life-threatening blood coagulation disorder.
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4.发明授权Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties 失效含有6-肽基氨基-1-萘磺酰胺部分的肽模拟物公开(公告)号：US06566493B1
公开(公告)日：2003-05-20
申请号：US09308437
申请日：1999-09-09
申请人： Saulius Butenas , Kenneth G. Mann
发明人： Saulius Butenas , Kenneth G. Mann
IPC分类号： C07K702
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1024
摘要： Compounds of the following formula are disclosed, wherein R1 is a peptide and R2 is an amino acid or peptide as disclosed herein: The compounds are inhibitors of activated protein C.
摘要翻译： 公开了下式的化合物，其中R1是肽，R2是本文公开的氨基酸或肽：化合物是活化蛋白C的抑制剂
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5.发明授权6-peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates 失效用作荧光蛋白水解酶底物的6-肽基氨基-1-萘磺酰胺
公开(公告)号：US5399487A
公开(公告)日：1995-03-21
申请号：US27294
申请日：1993-03-04
IPC分类号： C07D209/48 , C07K5/083 , C12Q1/37 , C12Q1/56 , C07D257/08 , C07D273/04 , C12Q1/00
CPC分类号： C07D209/48 , C07K5/0808 , C12Q1/37 , C12Q1/56 , C12Q2337/30 , Y10S514/822
摘要： The present invention encompasses compounds of formula I: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof; wherein R.sub.1 is hydrogen, lower alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, or phenylalkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, or phenylalkyl; orNR.sub.1 R.sub.2 forms a nitrogen heterocycle; andR.sub.3 is hydrogen, an amino acid or a peptide residue.These compounds may be employed as substrates in assays for determining proteolytic enzyme activity or as enzyme inhibitors. The invention also encompasses methods for determining proteolytic enzyme activity using the compounds of formula I.
摘要翻译： 本发明包括式I化合物及其药学上可接受的无毒盐; 其中R1是氢，低级烷基，烯基，炔基，环烷基，烷基环烷基，环烷基烷基或苯基烷基; R2是氢，烷基，烯基，炔基，环烷基，烷基环烷基，环烷基烷基或苯基烷基; 或NR1R2形成氮杂环; 并且R 3是氢，氨基酸或肽残基。 这些化合物可以用作用于测定蛋白水解酶活性的测定中的底物或作为酶抑制剂。 本发明还包括使用式I化合物测定蛋白水解酶活性的方法。
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公开(公告)号：US20090325203A1
公开(公告)日：2009-12-31
申请号：US12554610
申请日：2009-09-04
申请人： Richard J. Jenny , Saulius Butenas
发明人： Richard J. Jenny , Saulius Butenas
IPC分类号： G01N33/53
CPC分类号： C12Q1/37 , C12Q1/56 , G01N2333/96447
摘要： The invention provides assays for detecting and quantitating tissue factor and factor VIIa in simple and complex biological systems. The assays are performed by detecting and/or measuring the tissue factor cofactor activity and factor VIIa enzymatic activity using aminonaphthalene-based fluorogenic substrates.
摘要翻译： 本发明提供用于在简单和复杂的生物系统中检测和定量组织因子和因子VIIa的测定。 通过使用基于氨基萘的荧光底物检测和/或测量组织因子辅因子活性和因子VIIa酶活性来进行测定。
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公开(公告)号：US07604932B2
公开(公告)日：2009-10-20
申请号：US10534187
申请日：2003-11-06
申请人： Richard J. Jenny , Saulius Butenas
发明人： Richard J. Jenny , Saulius Butenas
IPC分类号： C12Q1/00
CPC分类号： C12Q1/37 , C12Q1/56 , G01N2333/96447
摘要： The invention provides assays for detecting and quantitating tissue factor and factor VIIa in simple and complex biological systems. The assays are performed by detecting and/or measuring the tissue factor cofactor activity and factor VIIa enzymatic activity using aminonapthalene-based fluorogenic substrates.
摘要翻译： 本发明提供用于在简单和复杂的生物系统中检测和定量组织因子和因子VIIa的测定。 通过使用基于氨基萘的荧光底物检测和/或测量组织因子辅因子活性和因子VIIa酶活性来进行测定。
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公开(公告)号：US20060148022A1
公开(公告)日：2006-07-06
申请号：US10534187
申请日：2003-11-06
申请人： Richard Jenny , Saulius Butenas
发明人： Richard Jenny , Saulius Butenas
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12Q1/56 , G01N2333/96447
摘要： The invention provides assays for detecting and quantitating tissue factor and factor VIIa in simple and complex biological systems. The assays are performed by detecting and/or measuring the tissue factor cofactor activity and factor VIIa enzymatic activity using aminonapthalene-based fluorogenic substrates.
摘要翻译： 本发明提供用于在简单和复杂的生物系统中检测和定量组织因子和因子VIIa的测定。 通过使用基于氨基萘的荧光底物检测和/或测量组织因子辅因子活性和因子VIIa酶活性来进行测定。
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