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公开(公告)号：US20130054507A1
公开(公告)日：2013-02-28
申请号：US13662680
申请日：2012-10-29
IPC分类号： G06N5/02
CPC分类号： G06N5/046 , G06F11/3604 , G06F11/3612 , G06N5/00 , G06N5/043 , H04L41/0213 , H04L41/046 , H04L41/0631 , H04L41/16 , H04L41/22 , H04L43/0817
摘要： A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed. The computer system being managed can also request the management system to process its knowledge base for possible problem cause analysis. The management system can also continually identify persisting problem causing symptoms.
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公开(公告)号：US20120266234A1
公开(公告)日：2012-10-18
申请号：US13530986
申请日：2012-06-22
申请人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Sukhija , John Purrier , Rajesh Gupta , Deepak Khajuria , Saumitra Das
发明人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Sukhija , John Purrier , Rajesh Gupta , Deepak Khajuria , Saumitra Das
IPC分类号： G06F15/173 , G06F11/20 , G06F21/00
CPC分类号： G06F11/2023 , H04L67/14 , H04L67/2819 , H04L67/2861 , H04L67/327 , H04L69/40
摘要： A service appliance is installed between production servers running service applications and service users. The production servers and their service applications provide services to the service users. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability. To maintain transparency to service users and service applications, service users are located on a first network and production servers are located on a second network. The service appliance assumes the addresses of the service users on the second network and the addresses of the production servers on the first network. Thus, the service appliance obtains all network traffic sent between the production server and service users. While the service application is operating correctly, the service appliance forwards network traffic between the two networks using various network layers.
摘要翻译： 服务设备安装在运行服务应用程序的生产服务器和服务用户之间。 生产服务器及其服务应用程序向服务用户提供服务。 如果生产服务器无法向用户提供服务，则服务设备可以透明地介入以维护服务可用性。 为了保持服务用户和服务应用程序的透明度，服务用户位于第一个网络上，生产服务器位于第二个网络上。 服务设备假定第二个网络上的服务用户的地址以及第一个网络上的生产服务器的地址。 因此，服务设备获取在生产服务器和服务用户之间发送的所有网络流量。 当服务应用程序正常运行时，服务设备使用各种网络层在两个网络之间转发网络流量。
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公开(公告)号：US07833987B2
公开(公告)日：2010-11-16
申请号：US10598700
申请日：2005-03-10
申请人： Partho Sarothi Ray , Saumitra Das
发明人： Partho Sarothi Ray , Saumitra Das
CPC分类号： C12N15/1131 , A61K31/7088 , C12N2310/111 , C12N2310/13 , C12N2310/53
摘要： Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5′untranslated region (5′UTR). We have investigated whether small RNA molecules corresponding to the different stem-loop (SL) domains of the HCV IRES, when introduced in trans, can bind to the cellular proteins and antagonize their binding to the viral IRES, thereby inhibiting HCV IRES-mediated translation. We have found that an RNA molecule corresponding to SL III of the HCV IRES could efficiently inhibit HCV IRES-mediated translation in a dose-dependent manner without affecting cap-dependent translation. The SL III RNA was also found to bind efficiently to most of the cellular proteins which interacted with the HCV 5′UTR. A smaller RNA corresponding to SL e+f of domain III also strongly and selectively inhibited HCV IRES-mediated translation. This RNA molecule showed strong interaction with the ribosomal S5 protein and prevented the recruitment of the 40S ribosomal subunit by the HCV IRES. In conclusion our results demonstrate a novel approach to selectively block HCV RNA translation using a small RNA molecules mimicking the structure of the stem-loop IIIe+f subdomain of the HCV-IRES. The discovery provides a basis for developing a potent antiviral therapy targeting the interaction between the ribosome and the HCV-IRES RNA.
摘要翻译： 丙型肝炎病毒（HCV）RNA的翻译由核糖体和细胞蛋白与位于5'非翻译区（5'UTR）内部核糖体进入位点（IRES）的相互作用介导。 我们已经研究了当IRIR引入反应时，对应于HCV IRES的不同茎环（SL）结构域的小RNA分子是否可以结合细胞蛋白并拮抗它们与病毒IRES的结合，从而抑制HCV IRES介导的翻译 。 我们发现对应于HCV IRES的SL III的RNA分子可以以剂量依赖的方式有效地抑制HCV IRES介导的翻译，而不影响帽依赖性翻译。 还发现SL III RNA有效地结合与HCV 5'UTR相互作用的大多数细胞蛋白质。 对应于结构域III的SLe + f的较小RNA也强烈和选择性地抑制HCV IRES介导的翻译。 这种RNA分子与核糖体S5蛋白表现出强烈的相互作用，并阻止了HCV IRES对40S核糖体亚基的募集。 总之，我们的结果证明了一种使用模拟HCV-IRES的茎环IIIe + f亚结构的小RNA分子选择性阻断HCV RNA翻译的新方法。 该发现为开发针对核糖体和HCV-IRES RNA之间的相互作用的强效抗病毒治疗提供了基础。
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公开(公告)号：US20100192005A1
公开(公告)日：2010-07-29
申请号：US12661244
申请日：2010-03-12
CPC分类号： G06N5/046 , G06F11/3604 , G06F11/3612 , G06N5/00 , G06N5/043 , H04L41/0213 , H04L41/046 , H04L41/0631 , H04L41/16 , H04L41/22 , H04L43/0817
摘要： A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed. The computer system being managed can also request the management system to process its knowledge base for possible problem cause analysis. The management system can also continually identify persisting problem causing symptoms.
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公开(公告)号：US07707133B2
公开(公告)日：2010-04-27
申请号：US11585660
申请日：2006-10-23
CPC分类号： G06N5/046 , G06F11/3604 , G06F11/3612 , G06N5/00 , G06N5/043 , H04L41/0213 , H04L41/046 , H04L41/0631 , H04L41/16 , H04L41/22 , H04L43/0817
摘要： A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed. The computer system being managed can also request the management system to process its knowledge base for possible problem cause analysis. The management system can also continually identify persisting problem causing symptoms.
摘要翻译： 公开了一种用于计算机系统的管理系统。 计算机系统运行或包括可以在管理系统中管理的各种产品（例如，软件产品）或由一组管理系统集体管理。 通常，管理系统在与被管理的计算机系统分离的计算机上操作。 管理系统可以利用在其他站点或计算机系统上引起以前观察到的问题的症状的知识库。 换句话说，知识库可以由不同用户跨越不同产品构建和共享，以利用其他不同的知识。 知识库通常随着时间的推移而增长。 管理系统可以利用其从与知识库一起管理的计算机系统请求信息的能力来推断正在管理的计算机系统中的问题根本原因。 被管理的计算机系统还可以请求管理系统处理其可能的问题原因分析的知识库。 管理系统也可以不断识别持续存在的问题引起的症状。
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公开(公告)号：US20060015645A1
公开(公告)日：2006-01-19
申请号：US11166359
申请日：2005-06-24
申请人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Kalia , John Purrier , Rajesh Gupta , Deepak Khajuria , Saumitra Das
发明人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Kalia , John Purrier , Rajesh Gupta , Deepak Khajuria , Saumitra Das
IPC分类号： G06F15/173
CPC分类号： G06F11/2023 , H04L67/14 , H04L67/2819 , H04L67/2861 , H04L67/327 , H04L69/40
摘要： A service appliance is installed between production servers running service applications and service users. The production servers and their service applications provide services to the service users. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability. To maintain transparency to service users and service applications, service users are located on a first network and production servers are located on a second network. The service appliance assumes the addresses of the service users on the second network and the addresses of the production servers on the first network. Thus, the service appliance obtains all network traffic sent between the production server and service users. While the service application is operating correctly, the service appliance forwards network traffic between the two networks using various network layers.
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7.发明授权Interference with viral IRES-mediated translation by a small yeast RNA reveals critical RNA-protein interactions 失效通过小型酵母RNA对病毒IRES介导的翻译的干扰揭示了关键的RNA-蛋白质相互作用公开(公告)号：US06291637B1
公开(公告)日：2001-09-18
申请号：US09316630
申请日：1999-05-21
申请人： Saumitra Das , Asim Dasgupta
发明人： Saumitra Das , Asim Dasgupta
IPC分类号： C07K500
CPC分类号： C12N15/113 , A61K38/00 , C07K14/4703 , C12N15/1034 , C12N15/11 , C12N15/1131 , C12N2310/111 , C12N2310/13 , C12Q1/6897 , Y02A50/463
摘要： Peptides and RNA oligonucleotides and methods of use for the inhibition of translation of an mRNA, which is initiated at an internal ribosome entry site of the mRNA and requires binding of a protein factor to that site, are disclosed. Peptides comprising the La autoantigen binding domain (LAP) are disclosed. LAP peptides alone or in combination with inhibitor RNA oligonucleotides (IRNA) may be used as antiviral agents to inhibit internal ribosome entry site (IRES) mediated viral replication.
摘要翻译： 公开了肽和RNA寡核苷酸以及用于抑制mRNA翻译的mRNA的方法，其在mRNA的内部核糖体进入位点引发并需要蛋白质因子与该位点的结合。 公开了包含La自身抗原结合结构域（LAP）的肽。 单独的或与抑制剂RNA寡核苷酸（IRNA）组合的LAP肽可以用作抗病毒剂以抑制内部核糖体进入位点（IRES）介导的病毒复制。
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公开(公告)号：US08301580B2
公开(公告)日：2012-10-30
申请号：US12661244
申请日：2010-03-12
CPC分类号： G06N5/046 , G06F11/3604 , G06F11/3612 , G06N5/00 , G06N5/043 , H04L41/0213 , H04L41/046 , H04L41/0631 , H04L41/16 , H04L41/22 , H04L43/0817
摘要： A management system for a computer system is disclosed. The computer system operates or includes various products (e.g., software products) that can be managed in a management system or collectively by a group of management systems. Typically, the management system operates on a computer separate from the computer system being managed. The management system can make use of a knowledge base of causing symptoms for previously observed problems at other sites or computer systems. In other words, the knowledge base can built from and shared by different users across different products to leverage knowledge that is otherwise disparate. The knowledge base typically grows over time. The management system can use its ability to request information from the computer system being managed together with the knowledge base to infer a problem root cause in the computer system being managed. The computer system being managed can also request the management system to process its knowledge base for possible problem cause analysis. The management system can also continually identify persisting problem causing symptoms.
摘要翻译： 公开了一种用于计算机系统的管理系统。 计算机系统运行或包括可以在管理系统中管理的各种产品（例如，软件产品）或由一组管理系统集体管理。 通常，管理系统在与被管理的计算机系统分离的计算机上操作。 管理系统可以利用在其他站点或计算机系统上引起以前观察到的问题的症状的知识库。 换句话说，知识库可以由不同用户跨越不同产品构建和共享，以利用其他不同的知识。 知识库通常随着时间的推移而增长。 管理系统可以利用其从与知识库一起管理的计算机系统请求信息的能力来推断正在管理的计算机系统中的问题根本原因。 被管理的计算机系统还可以请求管理系统处理其可能的问题原因分析的知识库。 管理系统也可以不断识别持续存在的问题引起的症状。
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公开(公告)号：US20090083443A1
公开(公告)日：2009-03-26
申请号：US12058550
申请日：2008-03-28
申请人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Sukhija , John Purrier , Rajesh Gupta , Saumitra Das
发明人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Sukhija , John Purrier , Rajesh Gupta , Saumitra Das
IPC分类号： G06F15/16
CPC分类号： G06F11/2048 , G06F11/1662 , G06F11/2028 , G06F11/2038 , G06F11/2097
摘要： A service appliance is installed between a production server running a service applications and service users. Upon being connected with the production server, the service appliance contacts the production server and/or service application and automatically replicates the service data from the service application. As additional service data is added to or modified by the service application of the production server, the service appliance automatically updates its replica of the data. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability using the replica of the data. When an operational production server is connected with the service appliance, the service appliance can automatically copy its service data to the service application of the operational production server. The operational production server can be the same as the original production server or a new production server.
摘要翻译： 服务设备安装在运行服务应用程序的生产服务器和服务用户之间。 在与生产服务器连接时，服务设备联系生产服务器和/或服务应用，并且自动地从服务应用程序复制服务数据。 随着附加服务数据被添加到生产服务器的服务应用程序或由生产服务器的服务应用程序进行修改，服务设备会自动更新其数据副本。 如果生产服务器无法向用户提供服务，则服务设备可以透明地介入以使用数据副本来维护服务可用性。 当操作生产服务器与服务设备连接时，服务设备可以自动将其服务数据复制到操作生产服务器的服务应用程序。 操作生产服务器可以与原始生产服务器或新的生产服务器相同。
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公开(公告)号：US07363365B2
公开(公告)日：2008-04-22
申请号：US11166043
申请日：2005-06-24
申请人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Sukhija , John Purrier , Rajesh Gupta , Saumitra Das
发明人： Matt Ocko , George Tuma , Manish Kalia , Sandeep Sukhija , John Purrier , Rajesh Gupta , Saumitra Das
IPC分类号： G06F15/173
CPC分类号： G06F11/2048 , G06F11/1662 , G06F11/2028 , G06F11/2038 , G06F11/2097
摘要： A service appliance is installed between a production server running a service applications and service users. Upon being connected with the production server, the service appliance contacts the production server and/or service application and automatically replicates the service data from the service application. As additional service data is added to or modified by the service application of the production server, the service appliance automatically updates its replica of the data. In the event that a production server is unable to provide its service to users, the service appliance can transparently intervene to maintain service availability using the replica of the data. When an operational production server is connected with the service appliance, the service appliance can automatically copy its service data to the service application of the operational production server. The operational production server can be the same as the original production server or a new production server.
摘要翻译： 服务设备安装在运行服务应用程序的生产服务器和服务用户之间。 在与生产服务器连接时，服务设备联系生产服务器和/或服务应用，并且自动地从服务应用程序复制服务数据。 随着附加服务数据被添加到生产服务器的服务应用程序或由生产服务器的服务应用程序进行修改，服务设备会自动更新其数据副本。 如果生产服务器无法向用户提供服务，则服务设备可以透明地介入以使用数据副本来维护服务可用性。 当操作生产服务器与服务设备连接时，服务设备可以自动将其服务数据复制到操作生产服务器的服务应用程序。 操作生产服务器可以与原始生产服务器或新的生产服务器相同。
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