公开(公告)号：US20100310573A1

公开(公告)日：2010-12-09

申请号：US12647698

申请日：2009-12-28

申请人： Tomoaki NAKAGAWA ,  Sayaka HORI ,  Rinpei NIWA ,  Tsuguo KUBOTA ,  Kazuhiro MASUDA ,  Kazuyasu NAKAMURA

发明人： Tomoaki NAKAGAWA ,  Sayaka HORI ,  Rinpei NIWA ,  Tsuguo KUBOTA ,  Kazuhiro MASUDA ,  Kazuyasu NAKAMURA

IPC分类号： A61K39/395 ,  C12N15/63 ,  C07K16/28 ,  C07H21/04 ,  C07K16/30 ,  A61P35/00 ,  A61P37/08 ,  A61P37/00 ,  C12N5/10 ,  C12P21/08 ,  G01N33/574 ,  G01N33/566

CPC分类号： C07K16/2812 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/70514

摘要： An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 与CD4结合的抗CD4抗体具有高亲和力并具有高效应活性，例如抗体依赖性细胞毒性（ADCC活性）或补体依赖性细胞毒性（CDC活性），涉及到疾病 到CD4表达细胞。 本发明可以提供以高亲和力结合CD4细胞外区域并且也表现出高ADCC活性或高CDC活性的单克隆抗体或其抗体片段; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂或使用该抗体或其抗体片段的诊断剂。

公开(公告)号：US20130177944A1

公开(公告)日：2013-07-11

申请号：US13755472

申请日：2013-01-31

申请人： Tomoaki NAKAGAWA ,  Sayaka HORI ,  Rinpei NIWA ,  Tsuguo KUBOTA ,  Kazuhiro MASUDA ,  Kazuyasu NAKAMURA

发明人： Tomoaki NAKAGAWA ,  Sayaka HORI ,  Rinpei NIWA ,  Tsuguo KUBOTA ,  Kazuhiro MASUDA ,  Kazuyasu NAKAMURA

IPC分类号： C07K16/28

CPC分类号： C07K16/2812 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/70514

摘要： An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 与CD4结合的抗CD4抗体具有高亲和力并具有高效应活性，例如抗体依赖性细胞毒性（ADCC活性）或补体依赖性细胞毒性（CDC活性），涉及到疾病 到CD4表达细胞。 本发明可以提供以高亲和力结合CD4细胞外区域并且也表现出高ADCC活性或高CDC活性的单克隆抗体或其抗体片段; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂或使用该抗体或其抗体片段的诊断剂。

公开(公告)号：US08399621B2

公开(公告)日：2013-03-19

申请号：US12647698

申请日：2009-12-28

申请人： Tomoaki Nakagawa ,  Sayaka Hori ,  Rinpei Niwa ,  Tsuguo Kubota ,  Kazuhiro Masuda ,  Kazuyasu Nakamura

发明人： Tomoaki Nakagawa ,  Sayaka Hori ,  Rinpei Niwa ,  Tsuguo Kubota ,  Kazuhiro Masuda ,  Kazuyasu Nakamura

IPC分类号： C07K16/00

CPC分类号： C07K16/2812 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/70514

摘要： An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 与CD4结合的抗CD4抗体具有高亲和力并具有高效应活性，例如抗体依赖性细胞毒性（ADCC活性）或补体依赖性细胞毒性（CDC活性），涉及到疾病 到CD4表达细胞。 本发明可以提供以高亲和力结合CD4细胞外区域并且也表现出高ADCC活性或高CDC活性的单克隆抗体或其抗体片段; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂或使用该抗体或其抗体片段的诊断剂。

公开(公告)号：US08877913B2

公开(公告)日：2014-11-04

申请号：US13755472

申请日：2013-01-31

申请人： Tomoaki Nakagawa ,  Sayaka Hori ,  Rinpei Niwa ,  Tsuguo Kubota ,  Kazuhiro Masuda ,  Kazuyasu Nakamura

发明人： Tomoaki Nakagawa ,  Sayaka Hori ,  Rinpei Niwa ,  Tsuguo Kubota ,  Kazuhiro Masuda ,  Kazuyasu Nakamura

IPC分类号： C07H21/04

CPC分类号： C07K16/2812 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/70514

摘要： An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.

摘要翻译： 与CD4结合的抗CD4抗体具有高亲和力并具有高效应活性，例如抗体依赖性细胞毒性（ADCC活性）或补体依赖性细胞毒性（CDC活性），涉及到疾病 到CD4表达细胞。 本发明可以提供以高亲和力结合CD4细胞外区域并且也表现出高ADCC活性或高CDC活性的单克隆抗体或其抗体片段; 产生抗体的杂交瘤; 编码抗体的DNA; 含有DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用该抗体或其抗体片段的治疗剂或使用该抗体或其抗体片段的诊断剂。