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公开(公告)号：US20130338202A1
公开(公告)日：2013-12-19
申请号：US14002164
申请日：2012-03-01
申请人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
发明人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
IPC分类号： C07D263/32 , A61J1/00
CPC分类号： C07D285/08 , A61J1/00 , C07C39/15 , C07C205/20 , C07C205/22 , C07C235/56 , C07C255/53 , C07D231/06 , C07D249/06 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/10 , C07D271/107 , C07D277/24 , C07D277/32 , C07D285/12 , C07D333/16 , C07D333/28 , C07D409/14
摘要： Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.
摘要翻译： 用于治疗突触核蛋白病的化合物及其药学上可接受的盐，例如帕金森病和tau蛋白病。
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公开(公告)号：US08865754B2
公开(公告)日：2014-10-21
申请号：US14002164
申请日：2012-03-01
申请人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
发明人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
IPC分类号： C07D263/32 , C07D277/32 , C07D333/16 , C07D285/12 , C07D263/56 , C07D271/107 , C07C205/22 , C07D263/57 , C07C255/53 , C07D249/06 , C07C235/56 , C07D277/24 , C07D271/10 , C07D333/28 , C07C205/20 , C07D409/14 , C07D285/08 , A61J1/00 , C07D231/06
CPC分类号： C07D285/08 , A61J1/00 , C07C39/15 , C07C205/20 , C07C205/22 , C07C235/56 , C07C255/53 , C07D231/06 , C07D249/06 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/10 , C07D271/107 , C07D277/24 , C07D277/32 , C07D285/12 , C07D333/16 , C07D333/28 , C07D409/14
摘要： Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.
摘要翻译： 用于治疗突触核蛋白病的化合物及其药学上可接受的盐，例如帕金森病和tau蛋白病。
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公开(公告)号：US20120251448A1
公开(公告)日：2012-10-04
申请号：US13411403
申请日：2012-03-02
申请人： Franz F. Hefti , Geoffrey Golding , Ximin Li , Seok-Rye Choi , Luke Esposito , Marisa-Claire Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Alan D. Snow
发明人： Franz F. Hefti , Geoffrey Golding , Ximin Li , Seok-Rye Choi , Luke Esposito , Marisa-Claire Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Alan D. Snow
CPC分类号： A61K51/0431 , A61K51/0453
摘要： Provided are the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of pathological characteristics unique to synuclein diseases, such as Parkinson's disease.
摘要翻译： 提供了所公开的化合物作为成像剂的用途和用于体内成像和检测突触核蛋白疾病如帕金森病特有的病理特征的方法。
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4.发明授权公开(公告)号：US06864393B2
公开(公告)日：2005-03-08
申请号：US10388363
申请日：2003-03-14
申请人： Hank F. Kung , Chyng-Yann Shiue , Shunichi Oya , Seok Rye Choi , Grace G. Shiue , Ping Fang
发明人： Hank F. Kung , Chyng-Yann Shiue , Shunichi Oya , Seok Rye Choi , Grace G. Shiue , Ping Fang
摘要： This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invetion, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
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5.发明授权公开(公告)号：US07041851B2
公开(公告)日：2006-05-09
申请号：US10388363
申请日：2003-03-14
申请人： Hank F. Kung , Chyng-Yann Shiue , Shunichi Oya , Seok Rye Choi , Grace G. Shiue , Ping Fang
发明人： Hank F. Kung , Chyng-Yann Shiue , Shunichi Oya , Seok Rye Choi , Grace G. Shiue , Ping Fang
IPC分类号： C07C321/28 , C07C321/30 , A61K31/10
CPC分类号： C07C323/37 , A61K51/0406 , C07C323/32
摘要： This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invetion, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
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