-
公开(公告)号：US20120251448A1
公开(公告)日：2012-10-04
申请号：US13411403
申请日：2012-03-02
申请人： Franz F. Hefti , Geoffrey Golding , Ximin Li , Seok-Rye Choi , Luke Esposito , Marisa-Claire Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Alan D. Snow
发明人： Franz F. Hefti , Geoffrey Golding , Ximin Li , Seok-Rye Choi , Luke Esposito , Marisa-Claire Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Alan D. Snow
CPC分类号： A61K51/0431 , A61K51/0453
摘要： Provided are the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of pathological characteristics unique to synuclein diseases, such as Parkinson's disease.
摘要翻译： 提供了所公开的化合物作为成像剂的用途和用于体内成像和检测突触核蛋白疾病如帕金森病特有的病理特征的方法。
-
公开(公告)号：US08865754B2
公开(公告)日：2014-10-21
申请号：US14002164
申请日：2012-03-01
申请人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
发明人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
IPC分类号： C07D263/32 , C07D277/32 , C07D333/16 , C07D285/12 , C07D263/56 , C07D271/107 , C07C205/22 , C07D263/57 , C07C255/53 , C07D249/06 , C07C235/56 , C07D277/24 , C07D271/10 , C07D333/28 , C07C205/20 , C07D409/14 , C07D285/08 , A61J1/00 , C07D231/06
CPC分类号： C07D285/08 , A61J1/00 , C07C39/15 , C07C205/20 , C07C205/22 , C07C235/56 , C07C255/53 , C07D231/06 , C07D249/06 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/10 , C07D271/107 , C07D277/24 , C07D277/32 , C07D285/12 , C07D333/16 , C07D333/28 , C07D409/14
摘要： Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.
摘要翻译： 用于治疗突触核蛋白病的化合物及其药学上可接受的盐，例如帕金森病和tau蛋白病。
-
公开(公告)号：US20130338202A1
公开(公告)日：2013-12-19
申请号：US14002164
申请日：2012-03-01
申请人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
发明人： Luke A. Esposito , Marisa C. Yadon , Joel Cummings , F. Michael Hudson , Thomas Lake , Franz F. Hefti , Geoffrey Golding , Seok-Rye Choi , Ximin Li , Alan D. Snow , Qubai Hu , Judy Cam
IPC分类号： C07D263/32 , A61J1/00
CPC分类号： C07D285/08 , A61J1/00 , C07C39/15 , C07C205/20 , C07C205/22 , C07C235/56 , C07C255/53 , C07D231/06 , C07D249/06 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/10 , C07D271/107 , C07D277/24 , C07D277/32 , C07D285/12 , C07D333/16 , C07D333/28 , C07D409/14
摘要： Compounds and their pharmaceutically acceptable salts for treatment of synucleinopathies, such as Parkinson's disease and tauopathies.
摘要翻译： 用于治疗突触核蛋白病的化合物及其药学上可接受的盐，例如帕金森病和tau蛋白病。
-
4.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF SYSTEMIC AA AMYLOID DISEASES 审中-公开用于治疗系统性AA亚型疾病的组合物和方法公开(公告)号：US20130137775A1
公开(公告)日：2013-05-30
申请号：US13747828
申请日：2013-01-23
申请人： Alan D. Snow , Thomas Lake , Luke Esposito , Kelsey Hanson , Marisa-Claire Yadon , Joel Cummings
发明人： Alan D. Snow , Thomas Lake , Luke Esposito , Kelsey Hanson , Marisa-Claire Yadon , Joel Cummings
IPC分类号： C07C235/56
CPC分类号： C07C235/56 , A61K9/1075 , A61K31/167
摘要： Bis- and tris-dihydroxyaryl compounds their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially AA amyloidosis, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，特别是AA型淀粉样变性的用途以及用于这种治疗的药物的制备中。
-
5.发明授权Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies 有权用于治疗β-淀粉样蛋白病和突触核蛋白病的化合物，组合物和方法公开(公告)号：US08829198B2
公开(公告)日：2014-09-09
申请号：US12244968
申请日：2008-10-03
申请人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow , Lesley Larsen
发明人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow , Lesley Larsen
IPC分类号： A61K31/4196 , A61K31/4164 , A61K31/18 , A61K31/05 , C07D249/08 , C07D233/54 , C07C311/29 , C07C39/10
CPC分类号： C07C311/29 , A61K31/05 , A61K31/18 , A61K31/4164 , A61K31/4196 , C07C37/16 , C07C39/10 , C07C39/17 , C07C2603/74 , C07D231/12 , C07D233/54 , C07D233/64 , C07D249/08
摘要： Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 二羟基芳基化合物和药学上可接受的酯，它们的合成，含有它们的药物组合物，以及它们在治疗淀粉样蛋白疾病（例如在阿尔茨海默病中观察到的）和突触核蛋白病（例如帕金森病中观察到的）和药物制造中的用途 用于治疗。
-
6.发明授权Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies 有权用于治疗淀粉样蛋白病和突触核蛋白病的化合物，组合物和方法公开(公告)号：US08916598B2
公开(公告)日：2014-12-23
申请号：US13207779
申请日：2011-08-11
申请人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow
发明人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow
IPC分类号： A61K31/4196 , A61P25/28 , A61P25/16 , C07D249/08 , C07D233/58 , A23L1/025 , A61K9/00 , A23L1/00 , A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , A23L5/00 , A23L5/32 , A23P10/40 , A23P30/20 , A61K9/0056 , A61K31/415 , A61K31/4196 , C07D233/58 , C07D249/08
摘要： Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 二羟基芳基化合物和药学上可接受的酯，它们的合成，含有它们的药物组合物，以及它们在治疗突触核蛋白病（例如帕金森病中观察到的）和用于这种治疗药物的制备中的用途。
-
7.发明申请Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies 有权用于治疗β-淀粉样蛋白病和突触核蛋白病的化合物，组合物和方法公开(公告)号：US20120035230A1
公开(公告)日：2012-02-09
申请号：US13207779
申请日：2011-08-11
申请人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow
发明人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow
IPC分类号： A61K31/4196 , A61P25/28 , A61P25/16 , A61K31/415
CPC分类号： C07D231/12 , A23L5/00 , A23L5/32 , A23P10/40 , A23P30/20 , A61K9/0056 , A61K31/415 , A61K31/4196 , C07D233/58 , C07D249/08
摘要： Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 二羟基芳基化合物和药学上可接受的酯，它们的合成，含有它们的药物组合物，以及它们在治疗突触核蛋白病（例如帕金森病中观察到的）和用于这种治疗药物的制备中的用途。
-
8.发明申请COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF BETA-AMYLOID DISEASES AND SYNUCLEINOPATHIES 失效化合物，组合物和治疗β-淀粉样变性疾病和综合征的方法公开(公告)号：US20120252858A1
公开(公告)日：2012-10-04
申请号：US13456691
申请日：2012-04-26
申请人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow , Lesley Larsen
发明人： Luke A. Esposito , F. Michael Hudson , Thomas Lake , Joel Cummings , Manfred Weigele , Alan D. Snow , Lesley Larsen
IPC分类号： A61K31/415 , A61P25/28 , A61P25/16 , C07D231/12
CPC分类号： C07C311/29 , A61K31/05 , A61K31/18 , A61K31/4164 , A61K31/4196 , C07C37/16 , C07C39/10 , C07C39/17 , C07C2603/74 , C07D231/12 , C07D233/54 , C07D233/64 , C07D249/08
摘要： Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 二羟基芳基化合物和药学上可接受的酯，它们的合成，含有它们的药物组合物，以及它们在治疗淀粉样蛋白疾病（例如在阿尔茨海默病中观察到的）和突触核蛋白病（例如帕金森病中观察到的）和药物制造中的用途 用于治疗。
-
9.发明授权Compounds, compositions, and methods for the treatment of synucleinopathies 有权用于治疗突触核蛋白病的化合物，组合物和方法公开(公告)号：US07919530B2
公开(公告)日：2011-04-05
申请号：US12500777
申请日：2009-07-10
IPC分类号： A61K31/17 , A61K31/167 , C07C275/32 , C07C233/24
CPC分类号： C07C39/15 , C07C39/16 , C07C39/17 , C07C69/017 , C07C215/50 , C07C217/32 , C07C233/56 , C07C235/24 , C07C235/38 , C07C235/52 , C07C235/54 , C07C235/56 , C07C235/74 , C07C235/76 , C07C273/1827 , C07C275/34 , C07C275/40 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗突触核蛋白病（例如帕金森病）中的用途以及制备用于这种治疗的药物。
-
10.发明申请公开(公告)号：US20100179223A1
公开(公告)日：2010-07-15
申请号：US12500777
申请日：2009-07-10
IPC分类号： A61K31/17 , A61K31/167 , A61K31/165
CPC分类号： C07C39/15 , C07C39/16 , C07C39/17 , C07C69/017 , C07C215/50 , C07C217/32 , C07C233/56 , C07C235/24 , C07C235/38 , C07C235/52 , C07C235/54 , C07C235/56 , C07C235/74 , C07C235/76 , C07C273/1827 , C07C275/34 , C07C275/40 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗突触核蛋白病（例如帕金森病）中的用途以及制备用于这种治疗的药物。
-
-
-
-
-
-
-
-
-
搜索结果
73 条记录 (耗时 0.043 秒)
