公开(公告)号：US20080008755A1

公开(公告)日：2008-01-10

申请号：US11777705

申请日：2007-07-13

申请人： Ick Chan Kwon ,  Seo Young Jeong ,  In-san Kim ,  Hesson Chung ,  Sang Bong Seo ,  Jae Hyung Park ,  Seunglee Kwon ,  Kwangmyung Kim ,  Jong-ho Kim

发明人： Ick Chan Kwon ,  Seo Young Jeong ,  In-san Kim ,  Hesson Chung ,  Sang Bong Seo ,  Jae Hyung Park ,  Seunglee Kwon ,  Kwangmyung Kim ,  Jong-ho Kim

IPC分类号： A61K9/24 ,  A61K31/7072 ,  A61K31/704 ,  A61K31/407 ,  A61K31/337 ,  C08B37/08 ,  A61K33/24

CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5161 ,  A61K47/61

摘要： Disclosed are a pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex and a preparation method thereof, and more particularly, the cholanic acid-chitosan complex composing of hydrophobic cholanic acid and hydrophilic chitosan forms self-aggregates in an aquatic environment. The pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex, wherein the cholanic acid-chitosan complex forms self-aggregates, prolongs the drug release period, enhances the selectivity of the complex for tumor tissue, and greatly increases drug loading content when a drug is incorporated into the self-aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the pharmaceutical formulation of the present invention is useful for anticancer chemotherapy.

摘要翻译： 公开了一种药物制剂，其特征在于将疏水性抗癌药物并入胆酸 - 壳聚糖复合物及其制备方法中，更具体地说，由疏水性胆酸和亲水性壳聚糖组成的胆酸 - 壳聚糖复合物形成自聚集体 水生环境。 药物制剂的特征在于将疏水性抗癌药物掺入胆酸 - 壳聚糖复合物中，其中胆酸 - 壳聚糖复合物形成自聚集体，延长药物释放时间，提高复合物对肿瘤组织的选择性，并大大增加 当药物掺入自聚集体中时，药物加载含量与化学键合相比，这限制了药物并入。 因此，本发明的药物制剂可用于抗癌化疗。