公开(公告)号：US06262272B1

公开(公告)日：2001-07-17

申请号：US09403985

申请日：1999-01-19

申请人： John Anthony Ragan ,  Teresa Woodall Makowski ,  David Jon Am Ende ,  Pamela Jane Clifford ,  Gregory Randall Young ,  Alyson Kay Conrad ,  Shane Allen Eisenbeis ,  George Joseph Quallich ,  Douglas John Meldrum Allen

发明人： John Anthony Ragan ,  Teresa Woodall Makowski ,  David Jon Am Ende ,  Pamela Jane Clifford ,  Gregory Randall Young ,  Alyson Kay Conrad ,  Shane Allen Eisenbeis ,  George Joseph Quallich ,  Douglas John Meldrum Allen

IPC分类号： C07D40100

CPC分类号： C07D405/12 ,  C07D209/42 ,  C07D307/83 ,  C07D307/84

摘要： A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.

摘要翻译： 制备选择性结合GABAa受体的吡咯 - 羧酰胺的方法; 其包括使1,3-环烷二酮与乙酸乙酯反应，随后将所得产物与酰卤反应，随后与芳族胺反应，最后在升高的温度下与二铵源反应。