公开(公告)号：US08147822B1

公开(公告)日：2012-04-03

申请号：US09664444

申请日：2000-09-18

申请人： John C. Bell ,  Nahum Sonenberg ,  David F. Stojdl ,  Earl G. Brown ,  Harold L. Atkins ,  Ricardo M. Marius ,  Brian D. Lichty ,  Shane B. Knowles

发明人： John C. Bell ,  Nahum Sonenberg ,  David F. Stojdl ,  Earl G. Brown ,  Harold L. Atkins ,  Ricardo M. Marius ,  Brian D. Lichty ,  Shane B. Knowles

IPC分类号： A61K35/76

CPC分类号： A61K35/766 ,  A61K38/21 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20251 ,  C12N2810/6081 ,  A61K2300/00

摘要： The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterized by having low levels, or no, PKR activity, or as being PKR−/−, STAT1−/− or both PKR−/− and STAT1−/−. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.

摘要翻译： 本发明涉及一种降低肿瘤细胞活力的方法，该方法涉及向肿瘤细胞施用不是常见的人类病原体的病毒。 优选地，病毒表现出差异的易感性，因为正常细胞不受病毒的影响。 这种差异敏感性在干扰素存在下更显着。 肿瘤细胞的特征在于具有低水平或无PKR活性，或PKR - / - ，STAT1 - /或PKR - / - 和STAT1 - / - 两者。 病毒选自由弹状病毒和小RNA病毒组成的组，优选为水泡性口炎病毒（VSV）或其衍生物。