公开(公告)号：US07544708B2

公开(公告)日：2009-06-09

申请号：US10520572

申请日：2003-04-11

Applicant: Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

Inventor： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

IPC: A61K31/40 ,  C07D209/44

CPC classification number: C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

Abstract translation: 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 具体地，本发明涉及氮杂双环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷和2,4,6-三取代的衍生物。 本发明还涉及含有化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。