公开(公告)号：US08815807B2

公开(公告)日：2014-08-26

申请号：US13309734

申请日：2011-12-02

申请人： Shigemi Nagai ,  Masazumi Nagai ,  Mindy Sungmin Gil

发明人： Shigemi Nagai ,  Masazumi Nagai ,  Mindy Sungmin Gil

IPC分类号： A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K17/02 ,  C40B60/12

CPC分类号： C40B60/12

摘要： Compositions and kits are provided having a peptide having an amino acid sequence that binds to eukaryotic cells and effects differentiation and support growth of the cells. Peptide-scaffold compositions containing at least one peptide or combinations of peptides are therapeutic agents for stimulating and promoting osteogenic activity and osteoinduction activity for cells. The scaffold is for example apatite, natural cancellous bone, demineralized natural cancellous bone, collagen, calcium phosphate, or hydroxyapatite.

摘要翻译： 提供组合物和试剂盒，其具有具有结合真核细胞并实现分化并支持细胞生长的氨基酸序列的肽。 含有至少一种肽或肽组合的肽 - 支架组合物是用于刺激和促进细胞的成骨活性和骨诱导活性的治疗剂。 脚手架是例如磷灰石，天然松质骨，软化天然松质骨，胶原蛋白，磷酸钙或羟基磷灰石。

公开(公告)号：US08647119B1

公开(公告)日：2014-02-11

申请号：US12729060

申请日：2010-03-22

申请人： Shigemi Nagai

发明人： Shigemi Nagai

IPC分类号： A61C5/00 ,  A61C1/00 ,  A61C3/00

CPC分类号： A61B5/0088

摘要： Methods and kits are provided for identifying carious lesions using a detectable fluorescent probe that binds to the lesion and an optical device. The detectable probe includes a molecule, a stain, a marker, and a dye capable of binding to a caries in the enamel layer of a tooth. The detectable probe is a fluorescent composition, or a bioluminescent composition, that emits a characteristic wavelength of light following illumination at an excitation wavelength.

摘要翻译： 提供方法和试剂盒用于使用结合病变的可检测荧光探针和光学装置鉴定龋损。 可检测的探针包括能够结合牙齿的牙釉质层中的龋齿的分子，染色剂，标记物和染料。 可检测的探针是荧光组合物或生物发光组合物，其在激发波长的照射下发射特征波长的光。

公开(公告)号：US20080038686A1

公开(公告)日：2008-02-14

申请号：US11787158

申请日：2007-04-13

申请人： Shigemi Nagai

发明人： Shigemi Nagai

IPC分类号： A61C19/06

CPC分类号： A61B5/0088

摘要： Methods and kits are provided for identifying very early stage carious lesions using a detectable probe that binds to the lesion.

摘要翻译： 提供方法和试剂盒用于使用结合病变的可检测探针来鉴定非常早期的龋齿损伤。

公开(公告)号：US20120148681A1

公开(公告)日：2012-06-14

申请号：US13309734

申请日：2011-12-02

申请人： Shigemi Nagai ,  Masazumi Nagai ,  Mindy Sungmin Gil

发明人： Shigemi Nagai ,  Masazumi Nagai ,  Mindy Sungmin Gil

IPC分类号： A61K38/08 ,  A61K38/10 ,  C07K7/08 ,  C07K7/06 ,  A61K35/32 ,  A61K33/42

CPC分类号： C40B60/12

摘要： Compositions and kits are provided having a peptide having an amino acid sequence that binds to eukaryotic cells and effects differentiation and support growth of the cells. Peptide-scaffold compositions containing at least one peptide or combinations of peptides are therapeutic agents for stimulating and promoting osteogenic activity and osteoinduction activity for cells. The scaffold is for example apatite, natural cancellous bone, demineralized natural cancellous bone, collagen, calcium phosphate, or hydroxyapatite.

摘要翻译： 提供组合物和试剂盒，其具有具有结合真核细胞并实现分化并支持细胞生长的氨基酸序列的肽。 含有至少一种肽或肽组合的肽 - 支架组合物是用于刺激和促进细胞的成骨活性和骨诱导活性的治疗剂。 脚手架是例如磷灰石，天然松质骨，软化天然松质骨，胶原蛋白，磷酸钙或羟基磷灰石。

公开(公告)号：US20110003702A1

公开(公告)日：2011-01-06

申请号：US12477186

申请日：2009-06-03

申请人： Shigemi Nagai ,  Masazzumi Nagai

发明人： Shigemi Nagai ,  Masazzumi Nagai

IPC分类号： C40B30/04 ,  C07K2/00 ,  C40B60/12

CPC分类号： G01N33/5008 ,  C40B60/12

摘要： Methods and systems for obtaining and identifying ligands that bind to cells and effect differentiation and/or support growth are provided herein. Several ligands were identified as proof of efficacy of the methods and systems, and amino acid sequences of compositions that effect differentiation of osteoblasts are thereby obtained.

摘要翻译： 本文提供了获得和鉴定结合细胞并影响分化和/或支持生长的配体的方法和系统。 鉴定了几种配体作为方法和系统的有效性的证据，从而获得了影响成骨细胞分化的组合物的氨基酸序列。