公开(公告)号：US20110294901A1

公开(公告)日：2011-12-01

申请号：US13147011

申请日：2010-01-29

Applicant: Shigeru Chikase ,  Dai Kawada

Inventor： Shigeru Chikase ,  Dai Kawada

IPC: A61K31/075 ,  A61P1/16

CPC classification number: A61K31/075 ,  A61K9/145 ,  A61K9/146

Abstract: An objective of the present invention is to provide a composition that has improved oral absorption and comprises a slightly soluble drug, and to provide a process for producing the same. According to the present invention, there is provided a finely pulverized composition comprising a slightly soluble drug such as 22β-methoxyolean-12-ene-3β, 24(4β)-diol and a hydrophilic surfactant. According to the present invention, there is also provided a process for producing the finely pulverized composition according to the present invention, characterized in that, after the dispersion of a slightly soluble drug and a hydrophilic surfactant in a solvent, the dispersion is pulverized with a high-pressure homogenizer.

Abstract translation: 本发明的目的是提供具有改善的口服吸收并且包含微溶性药物的组合物，并提供其制备方法。 根据本发明，提供了一种细微粉碎的组合物，其包含微量溶解的药物，例如22-二甲氧基安非炔-12-烯-3和bgr; 24（4'-二） - 二醇和亲水性表面活性剂。 根据本发明，还提供了根据本发明的细粉碎组合物的制造方法，其特征在于，将微溶性药物和亲水性表面活性剂分散在溶剂中后，将分散体用 高压均质机。

公开(公告)号：US08648065B2

公开(公告)日：2014-02-11

申请号：US10530046

申请日：2003-04-28

Applicant: Yukiko Yokoi ,  Shigeru Chikase ,  Hiroyuki Yamaguchi

Inventor： Yukiko Yokoi ,  Shigeru Chikase ,  Hiroyuki Yamaguchi

IPC: A61K31/545 ,  A01N43/04 ,  A61K31/715 ,  A61K31/70

CPC classification number: A61K31/546 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2054

Abstract: An objective of the present invention is to provide a cefditoren pivoxil pharmaceutical preparation which can safely be administered to a patient and not only improves wettability of cefditoren pivoxil, but also further improves absorbability through the intestinal tracts by maintaining amorphous particles having a high oral absorbability in a liquid for a long period of time. The present invention is a pharmaceutical composition comprising amorphous cefditoren pivoxil and a sucrose fatty acid ester, which is obtainable by mixing or wet-granulating particles containing amorphous cefditoren pivoxil with the sucrose fatty acid ester while amorphous cefditoren pivoxil maintains its particle state.

Abstract translation: 本发明的目的是提供一种可以安全地施用于患者的头孢托仑匹酯药物制剂，不仅改善了头孢托仑匹酯的润湿性，而且还通过维持具有高口服吸收性的无定形颗粒来进一步改善通过肠道的吸收性 液体很长一段时间。 本发明是包含无定形头孢托仑匹酯和蔗糖脂肪酸酯的药物组合物，其可通过将含有无定形头孢托仑匹酯的颗粒与蔗糖脂肪酸酯混合或湿法成粒，而无定形头孢托仑匹酯保持其颗粒状态。

公开(公告)号：US20070053973A1

公开(公告)日：2007-03-08

申请号：US10574979

申请日：2004-10-07

Applicant: Shigeru Chikase ,  Yukiko Yokoi

Inventor： Shigeru Chikase ,  Yukiko Yokoi

IPC: A61K31/545 ,  A61K9/20

CPC classification number: A61K9/0095 ,  A61K9/145 ,  A61K31/546

Abstract: According to the present invention, there is provided a solid dispersion composition which can maintain amorphous cefditoren pivoxil in a suspension for a long period of time. The present invention is a solid dispersion composition comprising at least 0.1 mg of a sugar ester fatty acid on the basis of an amount equivalent to 100 mg efficacy of cefditoren pivoxil.

Abstract translation: 根据本发明，提供一种能够长时间保持悬浮液中的无定形头孢托仑匹酯的固体分散体组合物。 本发明是一种固体分散体组合物，其包含至少0.1mg的基于相当于头孢托仑匹酯的100mg功效的量的糖酯脂肪酸。

公开(公告)号：US20060051411A1

公开(公告)日：2006-03-09

申请号：US10530046

申请日：2003-04-28

Applicant: Yukiko Yokoi ,  Shigeru Chikase ,  Hiroyuki Yamaguchi

Inventor： Yukiko Yokoi ,  Shigeru Chikase ,  Hiroyuki Yamaguchi

IPC: A61K31/7024 ,  A61K31/545 ,  A61K9/20

CPC classification number: A61K31/546 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2054

Abstract: An objective of the present invention is to provide a cefditoren pivoxil pharmaceutical preparation which can safely be administered to a patient and not only improves wettability of cefditoren pivoxil, but also further improves absorbability through the intestinal tracts by maintaining amorphous particles having a high oral absorbability in a liquid for a long period of time. The present invention is a pharmaceutical composition comprising amorphous cefditoren pivoxil and a sugar ester fatty acid, which is obtainable by mixing or wet-granulating particles containing amorphous cefditoren pivoxil with the sugar ester fatty acid while amorphous cefditoren pivoxil maintains its particle state.

Abstract translation: 本发明的目的是提供一种可以安全地施用于患者的头孢托仑匹酯药物制剂，不仅改善了头孢托仑匹酯的润湿性，而且还通过维持具有高口服吸收性的无定形颗粒来进一步改善通过肠道的吸收性 液体很长一段时间。 本发明是包含无定形头孢托仑匹酯和糖酯脂肪酸的药物组合物，其可通过将含有无定形头孢托仑匹酯的颗粒与糖酯脂肪酸混合或湿法制粒，而无定形头孢托仑匹酯保持其颗粒状态。