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公开(公告)号：US20070053973A1
公开(公告)日：2007-03-08
申请号：US10574979
申请日：2004-10-07
申请人： Shigeru Chikase , Yukiko Yokoi
发明人： Shigeru Chikase , Yukiko Yokoi
IPC分类号： A61K31/545 , A61K9/20
CPC分类号： A61K9/0095 , A61K9/145 , A61K31/546
摘要： According to the present invention, there is provided a solid dispersion composition which can maintain amorphous cefditoren pivoxil in a suspension for a long period of time. The present invention is a solid dispersion composition comprising at least 0.1 mg of a sugar ester fatty acid on the basis of an amount equivalent to 100 mg efficacy of cefditoren pivoxil.
摘要翻译： 根据本发明，提供一种能够长时间保持悬浮液中的无定形头孢托仑匹酯的固体分散体组合物。 本发明是一种固体分散体组合物，其包含至少0.1mg的基于相当于头孢托仑匹酯的100mg功效的量的糖酯脂肪酸。
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公开(公告)号：US20060051411A1
公开(公告)日：2006-03-09
申请号：US10530046
申请日：2003-04-28
IPC分类号： A61K31/7024 , A61K31/545 , A61K9/20
CPC分类号： A61K31/546 , A61K9/1623 , A61K9/2018 , A61K9/2054
摘要： An objective of the present invention is to provide a cefditoren pivoxil pharmaceutical preparation which can safely be administered to a patient and not only improves wettability of cefditoren pivoxil, but also further improves absorbability through the intestinal tracts by maintaining amorphous particles having a high oral absorbability in a liquid for a long period of time. The present invention is a pharmaceutical composition comprising amorphous cefditoren pivoxil and a sugar ester fatty acid, which is obtainable by mixing or wet-granulating particles containing amorphous cefditoren pivoxil with the sugar ester fatty acid while amorphous cefditoren pivoxil maintains its particle state.
摘要翻译： 本发明的目的是提供一种可以安全地施用于患者的头孢托仑匹酯药物制剂，不仅改善了头孢托仑匹酯的润湿性，而且还通过维持具有高口服吸收性的无定形颗粒来进一步改善通过肠道的吸收性 液体很长一段时间。 本发明是包含无定形头孢托仑匹酯和糖酯脂肪酸的药物组合物，其可通过将含有无定形头孢托仑匹酯的颗粒与糖酯脂肪酸混合或湿法制粒，而无定形头孢托仑匹酯保持其颗粒状态。
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公开(公告)号：US08648065B2
公开(公告)日：2014-02-11
申请号：US10530046
申请日：2003-04-28
IPC分类号： A61K31/545 , A01N43/04 , A61K31/715 , A61K31/70
CPC分类号： A61K31/546 , A61K9/1623 , A61K9/2018 , A61K9/2054
摘要： An objective of the present invention is to provide a cefditoren pivoxil pharmaceutical preparation which can safely be administered to a patient and not only improves wettability of cefditoren pivoxil, but also further improves absorbability through the intestinal tracts by maintaining amorphous particles having a high oral absorbability in a liquid for a long period of time. The present invention is a pharmaceutical composition comprising amorphous cefditoren pivoxil and a sucrose fatty acid ester, which is obtainable by mixing or wet-granulating particles containing amorphous cefditoren pivoxil with the sucrose fatty acid ester while amorphous cefditoren pivoxil maintains its particle state.
摘要翻译： 本发明的目的是提供一种可以安全地施用于患者的头孢托仑匹酯药物制剂，不仅改善了头孢托仑匹酯的润湿性，而且还通过维持具有高口服吸收性的无定形颗粒来进一步改善通过肠道的吸收性 液体很长一段时间。 本发明是包含无定形头孢托仑匹酯和蔗糖脂肪酸酯的药物组合物，其可通过将含有无定形头孢托仑匹酯的颗粒与蔗糖脂肪酸酯混合或湿法成粒，而无定形头孢托仑匹酯保持其颗粒状态。
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