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![3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2011/12/06/US08071129B2/abs.jpg.150x150.jpg)
1.发明授权3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) 有权3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] -2'-羟基 - 1,1'-联苯基] -3-羧酸双 - （单乙醇胺）公开(公告)号：US08071129B2
公开(公告)日：2011-12-06
申请号：US12607284
申请日：2009-10-28
IPC分类号： A61K9/20 , A61K31/4152 , C07D231/38
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl) -1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
摘要翻译： 公开了含有3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] - 2'-羟基 - [1,1'-联苯] -3-羧酸双 - （单乙醇胺）（丙酮胺）和其制备方法。
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![3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2010/02/25/US20100047347A1/abs.jpg.150x150.jpg)
公开(公告)号：US20100047347A1
公开(公告)日：2010-02-25
申请号：US12607320
申请日：2009-10-28
IPC分类号： A61K31/415 , A61K9/28
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
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![3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2011/11/08/US08052994B2/abs.jpg.150x150.jpg)
3.发明授权3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene] hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) 有权3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] -2'-羟基 - 1,1'-联苯基] -3-羧酸双 - （单乙醇胺）公开(公告)号：US08052994B2
公开(公告)日：2011-11-08
申请号：US12607305
申请日：2009-10-28
IPC分类号： A61K9/20 , A61K31/4152 , C07D231/38
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
摘要翻译： 公开了含有3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] - 2'-羟基 - [1,1'-联苯] -3-羧酸双 - （单乙醇胺）（丙酮胺）和其制备方法。
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![3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2010/02/25/US20100047348A1/abs.jpg.150x150.jpg)
公开(公告)号：US20100047348A1
公开(公告)日：2010-02-25
申请号：US12607330
申请日：2009-10-28
IPC分类号： A61K9/28 , A61K31/415 , A61K9/20
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
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公开(公告)号：US20160143883A1
公开(公告)日：2016-05-26
申请号：US14975930
申请日：2015-12-21
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , A61K31/4152
摘要： Invented is a method of treating thrombocytopenia in a human in need thereof which comprises the administration of a therapeutically effective amount of a 3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid to such human.
摘要翻译： 发明内容是一种在有需要的人中治疗血小板减少症的方法，其包括施用治疗有效量的3' - （N' - [1-（3,4-二甲基苯基）-3-甲基-5-氧代 - 1,5-二氢吡唑-4-亚基]肼基} -2'-羟基联苯-3-羧酸。
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公开(公告)号：US20120149749A1
公开(公告)日：2012-06-14
申请号：US13124182
申请日：2009-10-14
申请人： Michael Arning , Manuel Carlos Alves-Aivado , Roya Behbahani , Yanli Deng , Connie L. Erickson-Miller , Sophia M. Goodison , Julian Jenkins , Shivakumar G. Kapsi , Bhabita Mayer , Francis Xavier Muller , Bin Peng , Teresa S. Sellers , Nicole Lee Stone , Dickens Theodore , Dennis R. Williams , Mary Beth Wire
发明人： Michael Arning , Manuel Carlos Alves-Aivado , Roya Behbahani , Yanli Deng , Connie L. Erickson-Miller , Sophia M. Goodison , Julian Jenkins , Shivakumar G. Kapsi , Bhabita Mayer , Francis Xavier Muller , Bin Peng , Teresa S. Sellers , Nicole Lee Stone , Dickens Theodore , Dennis R. Williams , Mary Beth Wire
IPC分类号： A61K31/4152 , A61P7/02
CPC分类号： A61K31/415 , A61K31/4152
摘要： Invented is a method of treating thrombocytopenia in a human in need thereof which comprises the administration of a therapeutically effective amount of a 3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid to such human.
摘要翻译： 发明内容是一种在有需要的人中治疗血小板减少症的方法，其包括施用治疗有效量的3' - （N' - [1-（3,4-二甲基苯基）-3-甲基-5-氧代 - 1,5-二氢吡唑-4-亚基]肼基} -2'-羟基联苯-3-羧酸。
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![3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2011/11/08/US08052993B2/abs.jpg.150x150.jpg)
7.发明授权3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) 有权3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] -2'-羟基[1 ，1'-联苯] -3-羧酸双 - （单乙醇胺）公开(公告)号：US08052993B2
公开(公告)日：2011-11-08
申请号：US12607291
申请日：2009-10-28
IPC分类号： A61K9/20 , A61K31/4152 , C07D231/38
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl) -1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
摘要翻译： 公开了含有3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] - 2'-羟基 - [1,1'-联苯] -3-羧酸双 - （单乙醇胺）（丙酮胺）和其制备方法。
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公开(公告)号：US20100129352A1
公开(公告)日：2010-05-27
申请号：US12598673
申请日：2007-08-01
IPC分类号： A61K31/4152 , A61K39/395 , A61K38/02
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
摘要翻译： 公开了含有3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] - 2'-羟基 - [1,1'-联苯] -3-羧酸双 - （单乙醇胺）（丙酮胺）和其制备方法。
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![3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2010/02/25/US20100047346A1/abs.jpg.150x150.jpg)
公开(公告)号：US20100047346A1
公开(公告)日：2010-02-25
申请号：US12607305
申请日：2009-10-28
IPC分类号： A61K31/415 , A61K9/28
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
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![3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)](/abs-image/US/2010/02/18/US20100040683A1/abs.jpg.150x150.jpg)
10.发明申请3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) 有权3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] -2'-羟基 - 1,1'-联苯基] -3-羧酸双 - （单乙醇胺）公开(公告)号：US20100040683A1
公开(公告)日：2010-02-18
申请号：US12607284
申请日：2009-10-28
IPC分类号： A61K9/28 , A61K31/415
CPC分类号： A61K9/2077 , A61K9/19 , A61K9/20 , A61K9/2095 , A61K31/4152 , A61K47/26 , A61K47/34 , C07D231/46 , Y10T428/2982
摘要： Disclosed are novel pharmaceutical compositions containing 3′-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.
摘要翻译： 公开了含有3' - [（2Z） - [1-（3,4-二甲基苯基）-1,5-二氢-3-甲基-5-氧代-4H-吡唑-4-亚基]肼基] - 2'-羟基 - [1,1'-联苯] -3-羧酸双 - （单乙醇胺）（丙酮胺）和其制备方法。
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