公开(公告)号：US5385725A

公开(公告)日：1995-01-31

申请号：US225534

申请日：1994-04-11

申请人： Shoa-Lin Lin ,  Chung-Yuan Mou

发明人： Shoa-Lin Lin ,  Chung-Yuan Mou

IPC分类号： A61K49/22 ,  A61B8/00

CPC分类号： A61K49/223

摘要： An echo contrast agent for use in echocardiography is disclosed which can be introduced into the body through peripheral venous injection to opacify left ventricle. The echo agent to be injected into the body contains a plurality of gas-in-liquid microbubbles which are smaller than red blood cells and can therefore traverse the pulmonary circulation to reach the left ventricle in substantial quantity to effectuate opacification thereof. The echo contrast agent disclosed in this invention contains: (a) an aqueous solution containing 0.40-0.60 grams of albumin and 4.0-10.0 grams of glucose per 10 ml solution mixed with (b) glycerin. The ratio between (b) and (a) should be no less than 0.050. A method for preparing this echo contrast agent was also disclosed.

摘要翻译： 公开了一种用于超声心动图的回波造影剂，可通过外周静脉注射将其引入体内以使左心室不透明。 待注射到体内的回声剂含有多个比红细胞小的气体 - 液体微泡，因此可以大量穿过肺循环到达左心室，以达到其不透明度。 本发明公开的回波造影剂包含：（a）含有0.40-0.60克白蛋白和4.0-10.0克葡萄糖的水溶液，每10ml溶液与（b）甘油混合。 （b）和（a）之间的比例应不小于0.050。 还公开了一种制备该回波造影剂的方法。

公开(公告)号：US5302372A

公开(公告)日：1994-04-12

申请号：US919902

申请日：1992-07-27

申请人： Shoa-Lin Lin ,  Chung-Yuan Mou

发明人： Shoa-Lin Lin ,  Chung-Yuan Mou

IPC分类号： A61K49/22 ,  A61B8/00

CPC分类号： A61K49/223

摘要： An echo contrast agent for use in echocardiography is disclosed which can be introduced into the body through peripheral venous injection to opacify left ventricle. The echo agent to be injected into the body contains a plurality of gas-in-liquid microbubbles which are smaller than red blood cells and can therefore traverse the pulmonary circulation to reach the left ventricle in substantial quantity to effectuate opacification thereof. The echo contrast agent disclosed in this invention contains: (a) an aqueous solution containing 0.40-0.60 grams of albumin and 4.0-10.0 grams of glucose per 10 ml solution mixed with (b) glycerin. The ratio between (b) and (a) should be no less than 0.050. A method for preparing this echo contrast agent was also disclosed.

摘要翻译： 公开了一种用于超声心动图的回波造影剂，可通过外周静脉注射将其引入体内以使左心室不透明。 待注射到体内的回声剂含有多个比红细胞小的气体 - 液体微泡，因此可以大量穿过肺循环到达左心室，以达到其不透明度。 本发明公开的回波造影剂包含：（a）含有0.40-0.60克白蛋白和4.0-10.0克葡萄糖的水溶液，每10ml溶液与（b）甘油混合。 （b）和（a）之间的比例应不小于0.050。 还公开了一种制备该回波造影剂的方法。