公开(公告)号：US08252337B2

公开(公告)日：2012-08-28

申请号：US12581965

申请日：2009-10-20

申请人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

发明人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

IPC分类号： A61K9/14 ,  A61K47/18

CPC分类号： A61K9/5115

摘要： A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug.

摘要翻译： 公开了一种带电介孔二氧化硅纳米颗粒（MSN）的药物递送系统，用于控制释放和增强的生物利用度。 该系统包括带正电荷的MSN，其具有二氧化硅基质和基质中的孔和/或纳米通道阵列。 基质，全部表面和孔和/或纳米通道的整个物质包含多个硅烷醇（Si-OH）和季铵官能团。 带负电荷的生物活性化合物的生物利用度可以通过将其加载到孔和/或纳米通道中来增加。 在孔和/或纳米通道壁上的表面上的硅烷醇（Si-OH）官能团可以在pH高于带正电荷的MSN的pI的流体中游离去质子化并导致带负电荷的药物的持续释放 从孔和/或纳米通道，从而提高药物的生物利用度。

公开(公告)号：US06319486B1

公开(公告)日：2001-11-20

申请号：US09400930

申请日：1999-09-22

申请人： Chung-Yuan Mou ,  Hong-Ping Lin

发明人： Chung-Yuan Mou ,  Hong-Ping Lin

IPC分类号： C01B3700

CPC分类号： C01B37/00 ,  C01B37/02

摘要： The present invention relates to a method for synthesizing mesoporous aluminosilicate or pure-silica molecular sieves with newly hierarchical morphologies by adding suitable amount of alcohol. There are hollow sphere, hollow sphere with a pillar in it and solid sphere by adjusting the Al2O3/SiO2 and tetraethylorthosilicate/SiO2 ratio. The wall of the micron-sized spherical structure consisted of well-ordered cylindrical pores of nanometer size. The dimensions and the morphologies of the mesoporous structure are adjustable by varying the reaction components as the water content, the silicon/surfactant ratio and the reaction and the hydrothermal temperature.

摘要翻译： 本发明涉及通过添加适量的醇合成具有新分层形态的介孔硅铝酸盐或纯二氧化硅分子筛的方法。 有空心球体，其中有一个柱子的中空球体和通过调节Al2O3 / SiO2和原硅酸四乙酯/ SiO 2比例的固体球体。 微米尺寸的球形结构的壁由有序的纳米尺寸的圆柱形孔组成。 介孔结构的尺寸和形貌可以通过改变反应组分的含量，硅/表面活性剂比例和反应以及水热温度来调节。

公开(公告)号：US5302372A

公开(公告)日：1994-04-12

申请号：US919902

申请日：1992-07-27

申请人： Shoa-Lin Lin ,  Chung-Yuan Mou

发明人： Shoa-Lin Lin ,  Chung-Yuan Mou

IPC分类号： A61K49/22 ,  A61B8/00

CPC分类号： A61K49/223

摘要： An echo contrast agent for use in echocardiography is disclosed which can be introduced into the body through peripheral venous injection to opacify left ventricle. The echo agent to be injected into the body contains a plurality of gas-in-liquid microbubbles which are smaller than red blood cells and can therefore traverse the pulmonary circulation to reach the left ventricle in substantial quantity to effectuate opacification thereof. The echo contrast agent disclosed in this invention contains: (a) an aqueous solution containing 0.40-0.60 grams of albumin and 4.0-10.0 grams of glucose per 10 ml solution mixed with (b) glycerin. The ratio between (b) and (a) should be no less than 0.050. A method for preparing this echo contrast agent was also disclosed.

摘要翻译： 公开了一种用于超声心动图的回波造影剂，可通过外周静脉注射将其引入体内以使左心室不透明。 待注射到体内的回声剂含有多个比红细胞小的气体 - 液体微泡，因此可以大量穿过肺循环到达左心室，以达到其不透明度。 本发明公开的回波造影剂包含：（a）含有0.40-0.60克白蛋白和4.0-10.0克葡萄糖的水溶液，每10ml溶液与（b）甘油混合。 （b）和（a）之间的比例应不小于0.050。 还公开了一种制备该回波造影剂的方法。

公开(公告)号：US5876690A

公开(公告)日：1999-03-02

申请号：US798609

申请日：1997-02-11

申请人： Chung-Yuan Mou ,  Hong-Ping Lin

发明人： Chung-Yuan Mou ,  Hong-Ping Lin

IPC分类号： C01B39/04 ,  C01B39/02

CPC分类号： C01B39/04 ,  Y10S977/842

摘要： The present invention relates to a method for synthesizing mesoporous aluminosilicate and pure silica molecular sieves of new micro-tubular morphology. The wall of the microtubules contains coaxial cylindrical pores of nanometer size. The diameter of the hollow tubular is adjustable from 0.1 to 3 micrometer by varying the reaction conditions such as the surfactant/water ratio, the addition of salts or cosurfactants, the surfactants with different carbon chain length and the silicon/aluminum ratio.

摘要翻译： 本发明涉及新型微管形态的介孔硅铝酸盐和纯二氧化硅分子筛的合成方法。 微管壁包含纳米尺寸的同轴圆柱孔。 通过改变反应条件如表面活性剂/水比例，加入盐或辅助表面活性剂，具有不同碳链长度的表面活性剂和硅/铝比例，中空管的直径可从0.1至3微米调节。

公开(公告)号：US20100104650A1

公开(公告)日：2010-04-29

申请号：US12581965

申请日：2009-10-20

申请人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

发明人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

IPC分类号： A61K47/34 ,  A61K9/14

CPC分类号： A61K9/5115

摘要： A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug.

摘要翻译： 公开了一种带电介孔二氧化硅纳米颗粒（MSN）的药物递送系统，用于控制释放和增强的生物利用度。 该系统包括带正电荷的MSN，其具有二氧化硅基质和基质中的孔和/或纳米通道阵列。 基质，全部表面和孔和/或纳米通道的整个物质包含多个硅烷醇（Si-OH）和季铵官能团。 带负电荷的生物活性化合物的生物利用度可以通过将其加载到孔和/或纳米通道中来增加。 在孔和/或纳米通道壁上的表面上的硅烷醇（Si-OH）官能团可以在pH高于带正电荷的MSN的pI的流体中游离去质子化并导致带负电荷的药物的持续释放 从孔和/或纳米通道，从而提高药物的生物利用度。

公开(公告)号：US5385725A

公开(公告)日：1995-01-31

申请号：US225534

申请日：1994-04-11

申请人： Shoa-Lin Lin ,  Chung-Yuan Mou

发明人： Shoa-Lin Lin ,  Chung-Yuan Mou

IPC分类号： A61K49/22 ,  A61B8/00

CPC分类号： A61K49/223

摘要： An echo contrast agent for use in echocardiography is disclosed which can be introduced into the body through peripheral venous injection to opacify left ventricle. The echo agent to be injected into the body contains a plurality of gas-in-liquid microbubbles which are smaller than red blood cells and can therefore traverse the pulmonary circulation to reach the left ventricle in substantial quantity to effectuate opacification thereof. The echo contrast agent disclosed in this invention contains: (a) an aqueous solution containing 0.40-0.60 grams of albumin and 4.0-10.0 grams of glucose per 10 ml solution mixed with (b) glycerin. The ratio between (b) and (a) should be no less than 0.050. A method for preparing this echo contrast agent was also disclosed.

摘要翻译： 公开了一种用于超声心动图的回波造影剂，可通过外周静脉注射将其引入体内以使左心室不透明。 待注射到体内的回声剂含有多个比红细胞小的气体 - 液体微泡，因此可以大量穿过肺循环到达左心室，以达到其不透明度。 本发明公开的回波造影剂包含：（a）含有0.40-0.60克白蛋白和4.0-10.0克葡萄糖的水溶液，每10ml溶液与（b）甘油混合。 （b）和（a）之间的比例应不小于0.050。 还公开了一种制备该回波造影剂的方法。