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公开(公告)号：US20120053295A1
公开(公告)日：2012-03-01
申请号：US13147319
申请日：2010-02-15
申请人： Kazunori Kataoka , Shourong Wu , Takehiko Ishii , HyunJin Kim , Kanjiro Miyata , Nobuhiro Nishiyama
发明人： Kazunori Kataoka , Shourong Wu , Takehiko Ishii , HyunJin Kim , Kanjiro Miyata , Nobuhiro Nishiyama
CPC分类号： A61K48/0041 , A61K9/5192 , A61K31/7088 , A61K47/6455 , C07K14/001 , C07K14/003 , C08G69/08 , C08G69/10 , C08G69/48 , C12N15/111 , C12N2310/3181 , C12N2310/3513 , C12N2320/32
摘要： The present invention provides an efficient delivery system for a nucleic acid, more specifically, a cationic poly(amino acid) that has a side chain having a plurality of different amine functional groups in a moiety including a cationic group and that has a hydrophobic group introduced into part of the side chain, and a polyion complex (PIC) of the poly(amino acid) and an oligo- or polynucleotide.
摘要翻译： 本发明提供了一种用于核酸的有效递送系统，更具体地说，一种阳离子聚（氨基酸），该阳离子聚（氨基酸）在包括阳离子基团的部分中具有多个不同胺官能团的侧链，并且具有引入疏水基团 成为侧链的一部分，以及聚（氨基酸）的聚离子复合物（PIC）和寡核苷酸或多核苷酸。
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公开(公告)号：US08791086B2
公开(公告)日：2014-07-29
申请号：US13386154
申请日：2010-07-22
申请人： Kazunori Kataoka , Shourong Wu , Nobuhiro Nishiyama , Keiji Itaka , Hiroyuki Koyama , Takuya Hashimoto , Yuichi Tei
发明人： Kazunori Kataoka , Shourong Wu , Nobuhiro Nishiyama , Keiji Itaka , Hiroyuki Koyama , Takuya Hashimoto , Yuichi Tei
CPC分类号： A61K48/0025 , A61K31/7008 , A61K31/7088 , A61K38/18 , A61K45/06 , A61K47/595 , A61K47/60 , A61K47/6455 , C12N15/87 , A61K2300/00
摘要： The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.
摘要翻译： 本发明旨在提供一种具有更高安全性和更高可持续性的基因递送系统，其对于治疗缺血性疾病等是有效的。 本发明提供含有抑制PHD2的表达的聚阴离子物质作为活性成分的药物组合物，并含有聚阴离子物质和聚阳离子带电性聚合物的聚离子络合物。
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公开(公告)号：US08546487B2
公开(公告)日：2013-10-01
申请号：US13147319
申请日：2010-02-15
申请人： Kazunori Kataoka , Shourong Wu , Takehiko Ishii , HyunJin Kim , Kanjiro Miyata , Nobuhiro Nishiyama
发明人： Kazunori Kataoka , Shourong Wu , Takehiko Ishii , HyunJin Kim , Kanjiro Miyata , Nobuhiro Nishiyama
IPC分类号： A61K47/48 , C08F283/04 , A01N25/26
CPC分类号： A61K48/0041 , A61K9/5192 , A61K31/7088 , A61K47/6455 , C07K14/001 , C07K14/003 , C08G69/08 , C08G69/10 , C08G69/48 , C12N15/111 , C12N2310/3181 , C12N2310/3513 , C12N2320/32
摘要： The present invention provides an efficient delivery system for a nucleic acid, more specifically, a cationic poly(amino acid) that has a side chain having a plurality of different amine functional groups in a moiety including a cationic group and that has a hydrophobic group introduced into part of the side chain, and a polyion complex (PIC) of the poly(amino acid) and an oligo- or polynucleotide.
摘要翻译： 本发明提供了一种用于核酸的有效递送系统，更具体地说，一种阳离子聚（氨基酸），该阳离子聚（氨基酸）在包括阳离子基团的部分中具有多个不同胺官能团的侧链，并且具有引入疏水基团 成为侧链的一部分，以及聚（氨基酸）的聚离子复合物（PIC）和寡核苷酸或多核苷酸。
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公开(公告)号：US20120177594A1
公开(公告)日：2012-07-12
申请号：US13386154
申请日：2010-07-22
申请人： Kazunori Kataoka , Shourong Wu , Nobuhiro Nishiyama , Keiji Itaka , Hiroyuki Koyama , Takuya Hashimoto , Yuichi Tei
发明人： Kazunori Kataoka , Shourong Wu , Nobuhiro Nishiyama , Keiji Itaka , Hiroyuki Koyama , Takuya Hashimoto , Yuichi Tei
CPC分类号： A61K48/0025 , A61K31/7008 , A61K31/7088 , A61K38/18 , A61K45/06 , A61K47/595 , A61K47/60 , A61K47/6455 , C12N15/87 , A61K2300/00
摘要： The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.
摘要翻译： 本发明旨在提供一种具有更高安全性和更高可持续性的基因递送系统，其对于治疗缺血性疾病等是有效的。 本发明提供含有抑制PHD2的表达的聚阴离子物质作为活性成分的药物组合物，并含有聚阴离子物质和聚阳离子带电性聚合物的聚离子络合物。
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