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1.发明申请Mutants of Trichosanthin With Anti-Tumor Activity and Lowered Side-Effects 有权Trichosanthin突变体具有抗肿瘤活性和降低副作用公开(公告)号：US20080261874A1
公开(公告)日：2008-10-23
申请号：US11662460
申请日：2005-08-04
申请人： Chengcai An , Shuangli Mi , Ye Wang , Yin Gao
发明人： Chengcai An , Shuangli Mi , Ye Wang , Yin Gao
CPC分类号： C07K14/415
摘要： The invention provides the mutants and coding genes of trichosanthin (TCS). The mutants thereof are the TCS mutants with the single or double alternation of tyrosine-55 and aspartate-78 (counted from N-terminus), wherein the tyrosine-55 is mutated to an aliphatic amino acid and aspartate-78 is mutated to an amino acid with low hydrophilicity. This invention also relates to the application of TCS mutants and their coding genes in the drug development to treat carcinoma, AIDS and other diseases.
摘要翻译： 本发明提供了trichosanthin（TCS）的突变体和编码基因。 其突变体是具有酪氨酸-55和天冬氨酸-78（从N末端计数）的单次或双次交替的TCS突变体，其中酪氨酸-55突变为脂族氨基酸，天冬氨酸-78突变为氨基 酸性低亲水性。 本发明还涉及TCS突变体及其编码基因在药物开发中的应用以治疗癌，AIDS和其他疾病。
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2.发明授权Mutants of trichosanthin with anti-tumor activity and lowered side-effects 有权具有抗肿瘤活性和降低副作用的trichosanthin突变体公开(公告)号：US07763581B2
公开(公告)日：2010-07-27
申请号：US11662460
申请日：2005-08-04
申请人： Chengcai An , Shuangli Mi , Ye Wang , Yin Gao
发明人： Chengcai An , Shuangli Mi , Ye Wang , Yin Gao
IPC分类号： A61K38/00
CPC分类号： C07K14/415
摘要： The invention provides the mutants and coding genes of trichosanthin (TCS). The mutants thereof are the TCS mutants with the single or double alternation of tyrosine-55 and aspartate-78 (counted from N-terminus), wherein the tyrosine-55 is mutated to an aliphatic amino acid and aspartate-78 is mutated to an amino acid with low hydrophilicity. This invention also relates to the application of TCS mutants and their coding genes in the drug development to treat carcinoma, AIDS and other diseases.
摘要翻译： 本发明提供了trichosanthin（TCS）的突变体和编码基因。 其突变体是具有酪氨酸-55和天冬氨酸-78（从N末端计数）的单次或双次交替的TCS突变体，其中酪氨酸-55突变为脂族氨基酸，天冬氨酸-78突变为氨基 酸性低亲水性。 本发明还涉及TCS突变体及其编码基因在药物开发中的应用以治疗癌，AIDS和其他疾病。
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